

Biography
Dr. Fowler attended the Charing Cross Hospital Medical School, London, England. He has been elected to be a fellow in the Royal College of Physicians. He came to Stanford University on a British Heart Foundation, American Heart Association reciprocal fellowship award.
Dr. Fowler was appointed to the faculty in 1982. He is former Medical Director of the Heart Failure Program at Stanford University School of Medicine and Medical Director of the Stanford Cardiomyopathy Center.
Dr. Fowler has specialized in the treatment and research related to heart failure for over 35 years. He played an important role in the development of beta blocking drugs to treat heart failure and has also participated in most and the major studies that have led to our current comprehensive treatment for heart failure with drugs and devices. He is an expert in evaluating patients who may benefit from cardiac transplantation or mechanical support therapy.
Professional Summary
Professional Education
- Fellowship: Stanford University School of Medicine (1984) CA
- Research Fellowship, Stanford University School of Medicine (1984)
- Fellowship, Kings College Hospital UK (1982)
- Residency: Brighton and Sussex Medical School (1979) England
- Residency: Kent and Canterbury Hospital (1977) England
- Internship: New Charing Hosp - London (1976)
- Medical Education: Charing Cross Hospital Medical School (1975) UK
Administrative Appointments
- Assistant Professor of Medicine, CardiovascularMedicine, Stanford University Medical Center (1986 - 1993)
- Assoc. Prof. of Medicine, CardiovascularMedicine, Stanford University Medical Center (1993 - 1999)
- Clinical Asst. Prof. of Medicine, Stanford University Medical Center (1984 - 1986)
- Co-Director, Cardiac Advanced Therapies Clinic, Stanford University Medical Center (1984 - 1991)
- Co-Director, Coronary Care Unit, Stanford University Medical Center (1986 - 1991)
- Co-Director, Heart Failure Clinic, Stanford University Medical Center (1991 - 2001)
- Director, Heart Failure Program, Stanford University Medical Center (1991 - 2017)
- Medical Director, CardiomyopathyCenter, Stanford University Medical Center (2001 - Present)
- Professor of Medicine, CardiovascularMedicine, Stanford University Medical Center (1999 - Present)
Publications
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Selecting candidates for cardiac transplantation. How to assess exclusion criteria and predict who will benefit.
Rickenbacher, P. R., Haywood, G., & Fowler, M. B. (1995). Selecting candidates for cardiac transplantation. How to assess exclusion criteria and predict who will benefit. The Journal of Critical Illness, 10(3), 199–206. -
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Cardiopulmonary exercise testing and prognosis in severe heart failure: 14 mL/kg/min revisited
Myers, J., Gullestad, L., Vagelos, R., Do, D., Bellin, D., Ross, H., & Fowler, M. B. (2000). Cardiopulmonary exercise testing and prognosis in severe heart failure: 14 mL/kg/min revisited. AMERICAN HEART JOURNAL, 139(1), 78–84. -
The role of angiotensin receptor blockers in the management of chronic heart failure
Jamali, A. H., Tang, W. H. W., Khot, U. N., & Fowler, M. B. (2001). The role of angiotensin receptor blockers in the management of chronic heart failure. ARCHIVES OF INTERNAL MEDICINE, 161(5), 667–72. -
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Neurohormonal and clinical responses to high- versus low-dose enalapril therapy in chronic heart failure
Tang, W. H. W., Vagelos, R. H., Yee, Y. G., Benedict, C. R., Willson, K., Liss, C. L., … Fowler, M. B. (2002). Neurohormonal and clinical responses to high- versus low-dose enalapril therapy in chronic heart failure. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(1), 70–78. -
Beta-adrenergic blocking drugs in severe heart failure.
Fowler, M. (2002). Beta-adrenergic blocking drugs in severe heart failure. Reviews in Cardiovascular Medicine, 3, S20–6. -
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Carvedilol prospective randomized cumulative survival (COPERNICUS) trial: Carvedilol in severe heart failure
Fowler, M. B. (2004). Carvedilol prospective randomized cumulative survival (COPERNICUS) trial: Carvedilol in severe heart failure. AMERICAN JOURNAL OF CARDIOLOGY, 93(9A), 35B–39B. -
Insulin resistance in idiopathic dilated cardiomyopathy - A possible etiologic link
Witteles, R. M., Tang, W. H. W., Jamali, A. H., Chu, J. W., Reaven, G. M., & Fowler, M. B. (2004). Insulin resistance in idiopathic dilated cardiomyopathy - A possible etiologic link. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 44(1), 78–81. -
Care management for low-risk patients with heart failure - A randomized, controlled trial
DeBusk, R. F., Miller, N. H., Parker, K. M., Bandura, A., Kraemer, H. C., Cher, D. J., … Greenwald, G. (2004). Care management for low-risk patients with heart failure - A randomized, controlled trial. ANNALS OF INTERNAL MEDICINE, 141(8), 606–613. -
Emerging therapies for the management of decompensated heart failure - From bench to bedside
DeGoma, E. M., Vagelos, R. H., Fowler, M. B., & Ashley, E. A. (2006). Emerging therapies for the management of decompensated heart failure - From bench to bedside. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 48(12), 2397–2409. -
INFLUENCE OF PREOPERATIVE PULMONARY-ARTERY PRESSURE ON MORTALITY AFTER HEART-TRANSPLANTATION - TESTING OF POTENTIAL REVERSIBILITY OF PULMONARY-HYPERTENSION WITH NITROPRUSSIDE IS USEFUL IN DEFINING A HIGH-RISK GROUP
COSTARDJACKLE, A., & Fowler, M. B. (1992). INFLUENCE OF PREOPERATIVE PULMONARY-ARTERY PRESSURE ON MORTALITY AFTER HEART-TRANSPLANTATION - TESTING OF POTENTIAL REVERSIBILITY OF PULMONARY-HYPERTENSION WITH NITROPRUSSIDE IS USEFUL IN DEFINING A HIGH-RISK GROUP. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 19(1), 48–54. -
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Cardiomyopathy of insulin resistance.
Witteles, R. M., & Fowler, M. B. (2006). Cardiomyopathy of insulin resistance. Heart Failure Clinics, 2(1), 13–23. -
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Why do we need to prevent right ventricular pacing?
Tsiperfal, A., Scheibly, K., Fowler, M. B., & Chao, C. (2007). Why do we need to prevent right ventricular pacing? Progress in Cardiovascular Nursing, 22(2), 108–9. -
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Impact of nesiritide on renal function in patients with acute decompensated failure an pre-existing renal dysfunction - A randomized, double-blind, placebo-controlled clinical trial
Witteles, R. M., Kao, D., Christopherson, D., Matsuda, K., Vagelos, R. H., Schreiber, D., & Fowler, M. B. (2007). Impact of nesiritide on renal function in patients with acute decompensated failure an pre-existing renal dysfunction - A randomized, double-blind, placebo-controlled clinical trial. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 50(19), 1835–40. -
Insulin-resistant cardiomyopathy
Witteles, R. M., & Fowler, M. B. (2008). Insulin-resistant cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(2), 93–102. -
Hypertension, heart failure, and beta-adrenergic blocking drugs
Fowler, M. B. (2008). Hypertension, heart failure, and beta-adrenergic blocking drugs. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 52(13), 1073–1075. -
The influence of preoperative patient characteristics on early and late survival following cardiac transplantation.
Costard-Jäckle, A., Hill, I., Schroeder, J. S., & Fowler, M. B. (1991). The influence of preoperative patient characteristics on early and late survival following cardiac transplantation. Circulation, 84(5), III329–37. -
Worsening of Left Ventricular End-Systolic Volume and Mitral Regurgitation without Increase in Left Ventricular Dyssynchrony on Acute Interruption of Cardiac Resynchronization Therapy
Kuppahally, S. S., Fowler, M. B., Vagelos, R., Wang, P., Al-Ahmad, A., Paloma, A., & Liang, D. (2009). Worsening of Left Ventricular End-Systolic Volume and Mitral Regurgitation without Increase in Left Ventricular Dyssynchrony on Acute Interruption of Cardiac Resynchronization Therapy. ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 26(7), 759–65. -
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Measurement Precision in the Optimization of Cardiac Resynchronization Therapy
Turcott, R. G., Witteles, R. M., Wang, P. J., Vagelos, R. H., Fowler, M. B., & Ashley, E. A. (2010). Measurement Precision in the Optimization of Cardiac Resynchronization Therapy. CIRCULATION-HEART FAILURE, 3(3), 395–404. -
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Chemotherapy-Associated Cardiotoxicity: How Often Does it Really Occur and How Can it Be Prevented?
Witteles, R. M., Fowler, M. B., & Telli, M. L. (2011). Chemotherapy-Associated Cardiotoxicity: How Often Does it Really Occur and How Can it Be Prevented? HEART FAILURE CLINICS, 7(3), 333-? -
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Selection of patients for cardiac transplantation.
Vagelos, R., & Fowler, M. B. (1990). Selection of patients for cardiac transplantation. Cardiology Clinics, 8(1), 23–38. -
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HEMODYNAMIC, RENAL AND ENDOCRINE EFFECTS OF ATRIAL NATRIURETIC PEPTIDE INFUSION IN SEVERE HEART-FAILURE
Molina, C. R., Fowler, M. B., MCCRORY, S., Peterson, C., Myers, B. D., Schroeder, J. S., & Murad, F. (1988). HEMODYNAMIC, RENAL AND ENDOCRINE EFFECTS OF ATRIAL NATRIURETIC PEPTIDE INFUSION IN SEVERE HEART-FAILURE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 12(1), 175–86. -
ORTHOTOPIC CARDIAC TRANSPLANTATION FOR UNIVENTRICULAR HEART
Macoviak, J. A., Baldwin, J. C., Ginsburg, R., Fowler, M., Valentine, H., Oyer, P. E., & Stinson, E. B. (1988). ORTHOTOPIC CARDIAC TRANSPLANTATION FOR UNIVENTRICULAR HEART. ANNALS OF THORACIC SURGERY, 45(1), 85–86. -
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Controlled trials with beta blockers in heart failure: metoprolol as the prototype.
Fowler, M. B. (1993). Controlled trials with beta blockers in heart failure: metoprolol as the prototype. American Journal of Cardiology, 71(9), 45C–53C. -
Beta-blockers in heart failure: potential of carvedilol.
Fowler, M. B. (1993). Beta-blockers in heart failure: potential of carvedilol. Journal of Human Hypertension, 7, S62–7. -
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PROTECTIVE EFFECT OF CLENTIAZEM AGAINST EPINEPHRINE-INDUCED CARDIAC INJURY IN RATS
Deisher, T. A., Narita, H., ZERA, P., Ginsburg, R., Bristow, M. R., Billingham, M. E., … Hoffman, B. B. (1993). PROTECTIVE EFFECT OF CLENTIAZEM AGAINST EPINEPHRINE-INDUCED CARDIAC INJURY IN RATS. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 266(1), 262–269. -
The relationship of granzyme A and perforin expression to cardiac allograft rejection and dysfunction
Alpert, S., Lewis, N. P., Ross, H., Fowler, M., & Valantine, H. A. (1995). The relationship of granzyme A and perforin expression to cardiac allograft rejection and dysfunction. TRANSPLANTATION, 60(12), 1478–85. -
Transplant candidates with severe left ventricular dysfunction managed with medical treatment: Characteristics and survival
Rickenbacher, P. R., Trindade, P. T., Haywood, G. A., Vagelos, R. H., Schroeder, J. S., Willson, K., … Fowler, M. B. (1996). Transplant candidates with severe left ventricular dysfunction managed with medical treatment: Characteristics and survival. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 27(5), 1192–97. -
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Expression of inducible nitric oxide synthase fin human heart failure
Haywood, G. A., Tsao, P. S., VONDERLEYEN, H. E., Mann, M. J., Kelling, P. J., Trindade, P. T., … Fowler, M. B. (1996). Expression of inducible nitric oxide synthase fin human heart failure. CIRCULATION, 93(6), 1087–1094. -
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Spontaneous reversibility of catecholamine-induced cardiotoxicity in rats.
Deisher, T. A., Ginsburg, R., Fowler, M. B., Billingham, M. E., & Bristow, M. R. (1995). Spontaneous reversibility of catecholamine-induced cardiotoxicity in rats. The American Journal of Cardiovascular Pathology, 5(1), 79–88. -
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AT(1) and AT(2) angiotensin receptor gene expression in human heart failure
Haywood, G. A., Gullestad, L., Katsuya, T., Hutchinson, H. G., Pratt, R. E., Horiuchi, M., & Fowler, M. B. (1997). AT(1) and AT(2) angiotensin receptor gene expression in human heart failure. CIRCULATION, 95(5), 1201–1206. -
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Effects of beta blockers on symptoms and functional capacity in heart failure.
Fowler, M. B. (1997). Effects of beta blockers on symptoms and functional capacity in heart failure. American Journal of Cardiology, 80(11A), 55L–58L. -
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Effect of carvedilol on frequency and severity of hospitalization in severe chronic heart failure: Results of the COPERNICUS study
Fowler, M. B., O'Connor, C. M., Carson, P., Tendera, M., Katus, H. A., Krum, H., … Packer, M. (2001). Effect of carvedilol on frequency and severity of hospitalization in severe chronic heart failure: Results of the COPERNICUS study. CIRCULATION, 104(17), 753–754. -
A comprehensive management system for heart failure improves clinical outcomes and reduces medical resource utilization
West, J. A., Miller, N. H., Parker, K. M., Senneca, D., Ghandour, G., Clark, M., … DeBusk, R. F. (1997). A comprehensive management system for heart failure improves clinical outcomes and reduces medical resource utilization. AMERICAN JOURNAL OF CARDIOLOGY, 79(1), 58–63. -
High prevalence of impaired glucose metabolism in patients with idiopathic dilated cardiomyopathy
Jamali, A. H., Witteles, R. M., Tang, W. H. W., Chu, J. W., Reaven, G. M., & Fowler, M. B. (2002). High prevalence of impaired glucose metabolism in patients with idiopathic dilated cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5), 181A–181A. -
Left ventricular dyssynchrony does not deteriorate acutely on cessation of cardiac resynchronization therapy in long term responders
Kuppahally, S., Fowler, M., Wang, P., Vagelos, R., Al-Ahmad, A., Paloma, A., & Liang, D. (2006). Left ventricular dyssynchrony does not deteriorate acutely on cessation of cardiac resynchronization therapy in long term responders. JOURNAL OF CARDIAC FAILURE, 12(6), S76–S76. -
Baseline clinical parameters do not predict left ventricular ejection fraction improvement
Tang, W. H. W., Khot, U. N., Larson, M. S., Prikazsky, L., Hu, B. S., Tan, J. L., & Fowler, M. B. (2000). Baseline clinical parameters do not predict left ventricular ejection fraction improvement. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2), 207A–207A. -
Reverse remodeling following long-term carvedilol therapy is associated with improvement in survival: The Stanford Carvedilol Echocardiographic Registry
Tang, W. H. W., Larson, M. S., Vagelos, R. H., Prikazsky, L., Hu, B. S., & Fowler, M. B. (2002). Reverse remodeling following long-term carvedilol therapy is associated with improvement in survival: The Stanford Carvedilol Echocardiographic Registry. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5), 141A–141A. -
CHANGES IN DOPPLER ECHOCARDIOGRAPHIC INDEXES OF LEFT-VENTRICULAR FUNCTION AS POTENTIAL MARKERS OF ACUTE CARDIAC REJECTION
Valantine, H. A., Fowler, M. B., Hunt, S. A., NAASZ, C., Hatle, L. K., Billingham, M. E., … Popp, R. L. (1987). CHANGES IN DOPPLER ECHOCARDIOGRAPHIC INDEXES OF LEFT-VENTRICULAR FUNCTION AS POTENTIAL MARKERS OF ACUTE CARDIAC REJECTION. CIRCULATION, 76(5), 86–92. -
DOPPLER ECHO INDEXES OF LV-FILLING ASSOCIATED WITH IMPROVED HEMODYNAMICS FOLLOWING METOPROLOL THERAPY IN DILATED CARDIOMYOPATHY
Valantine, H. A., Hatle, L., HEILBRUNN, S., Oldershaw, P., Popp, R. L., & Fowler, M. B. (1987). DOPPLER ECHO INDEXES OF LV-FILLING ASSOCIATED WITH IMPROVED HEMODYNAMICS FOLLOWING METOPROLOL THERAPY IN DILATED CARDIOMYOPATHY. CIRCULATION, 76(4), 358–58. -
CHANGES IN DOPPLER AND M-MODE ECHOCARDIOGRAPHIC INDEXES OF LEFT-VENTRICULAR FUNCTION DURING ACUTE CARDIAC ALLOGRAFT-REJECTION
Valantine, H. A., Oldershaw, P. J., Fowler, M. B., Gibson, D. G., Hatle, L., Hunt, S. A., … Popp, R. L. (1987). CHANGES IN DOPPLER AND M-MODE ECHOCARDIOGRAPHIC INDEXES OF LEFT-VENTRICULAR FUNCTION DURING ACUTE CARDIAC ALLOGRAFT-REJECTION. BRITISH HEART JOURNAL, 57(1), 86–86. -
INFLUENCE OF PREOPERATIVE PATIENT CHARACTERISTICS ON EARLY AND LATE SURVIVAL FOLLOWING CARDIAC TRANSPLANTATION
COSTARDJACKLE, A., Hill, I., Schroeder, J. S., & Fowler, M. B. (1990). INFLUENCE OF PREOPERATIVE PATIENT CHARACTERISTICS ON EARLY AND LATE SURVIVAL FOLLOWING CARDIAC TRANSPLANTATION. CIRCULATION, 82(4), 715–715. -
Comparison of high versus low dose enalapril therapy on clinical outcomes and neuroendocrine activation in advanced heart failure
Fowler, M. B., Vagelos, R. H., Schroeder, J. S., Benedict, C. R., Willson, K., Boucher, M., … Labelle, P. (1997). Comparison of high versus low dose enalapril therapy on clinical outcomes and neuroendocrine activation in advanced heart failure. CIRCULATION, 96(8), 105–105. -
DECREASED CATECHOLAMINE SENSITIVITY AND UNCHANGED B-ADRENERGIC RECEPTOR DENSITY WITH XAMOTEROL, A PARTIAL B-AGONIST ANTAGONIST IN DILATED CARDIOMYOPATHY
Fowler, M. B., Dibiase, A., MCCRORY, S., & Yee, Y. G. (1990). DECREASED CATECHOLAMINE SENSITIVITY AND UNCHANGED B-ADRENERGIC RECEPTOR DENSITY WITH XAMOTEROL, A PARTIAL B-AGONIST ANTAGONIST IN DILATED CARDIOMYOPATHY. CIRCULATION, 82(4), 385–385. -
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A genetic locus for ventricular arrhythmia and dilated cardiomyopathy on chromosome 2
Dreher, D., Zhu, X. L., Hoang, K. L., Tan, J. L., Vagelos, R. H., Hunt, S. A., … McNally, E. M. (1999). A genetic locus for ventricular arrhythmia and dilated cardiomyopathy on chromosome 2. CIRCULATION, 100(18), 217–217. -
Ventricular arrhythmia and dilated cardiomyopathy is linked to chromosome 2.
Zhu, X., Dreher, D., Hoang, K., Tan, J., Hunt, S., Vagelos, R. H., … McNally, E. M. (1999). Ventricular arrhythmia and dilated cardiomyopathy is linked to chromosome 2. AMERICAN JOURNAL OF HUMAN GENETICS, 65(4), A455–A455. -
Coreg (R) Heart Failure Registry (COHERE): Characteristics of participating physicians, their patients, and dose-titration experience.
Franciosa, J. A., Abraham, W. T., Fowler, M. B., Gilbert, E. M., Greenberg, B. H., Massie, B. M., … Nelson, J. J. (2001). Coreg (R) Heart Failure Registry (COHERE): Characteristics of participating physicians, their patients, and dose-titration experience. CIRCULATION, 104(17), 801–801. -
DOPPLER ECHOCARDIOGRAPHIC INDEXES OF DIASTOLIC FUNCTION AS MARKERS OF ACUTE CARDIAC REJECTION
Valantine, H., Fowler, M., Hatle, L., Hunt, S., Billingham, M., STINSON, E., & Popp, R. (1987). DOPPLER ECHOCARDIOGRAPHIC INDEXES OF DIASTOLIC FUNCTION AS MARKERS OF ACUTE CARDIAC REJECTION. TRANSPLANTATION PROCEEDINGS, 19(1), 2556–59. -
Evaluation of Polymorphisms in Candidate Genes in the Dramatic Response to Pharmacologic Therapy of Heart Failure
Wheeler, M. T., Pavlovic, A., Dewey, F., Perez, M., Absher, D., Ho, M. Y., … Ashley, E. A. (2008). Evaluation of Polymorphisms in Candidate Genes in the Dramatic Response to Pharmacologic Therapy of Heart Failure. CIRCULATION RESEARCH, 103(5), E64–E65. -
Overrepresentation of neuronal development pathways in heart failure patients who dramatically responded to pharmaceutical therapy
Pavlovic, A., Perez, M., Absher, D., Wheeler, M., Ho, M., Dewey, R., … Ashley, E. (2008). Overrepresentation of neuronal development pathways in heart failure patients who dramatically responded to pharmaceutical therapy. JOURNAL OF CARDIAC FAILURE, 14(6), S41–S41. -
GENETIC DETERMINANTS OF DRAMATIC IMPROVEMENT IN LEFT VENTRICULAR FUNCTION IN PATIENTS WITH HEART FAILURE
Perez, M. V., Pavlovic, A., Wheeler, M. T., Dewey, F. E., Bernstein, D., Fowler, M. B., … Ashley, E. A. (2011). GENETIC DETERMINANTS OF DRAMATIC IMPROVEMENT IN LEFT VENTRICULAR FUNCTION IN PATIENTS WITH HEART FAILURE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14), E2041–E2041. -
Effect of carvedilol on survival and hospitalization in patients with ischemic or nonischemic cardiomyopathy
Bristow, M. R., Colucci, W. S., Fowler, M. B., Gilbert, E. M., Lukas, M. A., Young, S. T., … Liang, C. S. (1996). Effect of carvedilol on survival and hospitalization in patients with ischemic or nonischemic cardiomyopathy. CIRCULATION, 94(8), 1968–1968. -
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How does myocardial inducible nitric oxide synthase gene expression relate to heart failure severity and to subsequent left ventricular reverse remodeling in patients with chronic heart failure?
Tang, W. H. W., LOPEZ, F., Yee, Y. G., Mullin, A., Zhang, Y., & Fowler, M. B. (2004). How does myocardial inducible nitric oxide synthase gene expression relate to heart failure severity and to subsequent left ventricular reverse remodeling in patients with chronic heart failure? JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 43(5), 155A–155A. -
Influence of carvedilol therapy on myocardial expression of inducible nitric oxide synthase (NOS2) and the contractile response to beta-adrenergic inotropic stimulation in patients with dilated cardiomyopathy
Tang, W. H. W., LOPEZ, F., Lo, S. T., Yee, Y. G., Mullin, A., Zhang, Y., & Fowler, M. B. (2003). Influence of carvedilol therapy on myocardial expression of inducible nitric oxide synthase (NOS2) and the contractile response to beta-adrenergic inotropic stimulation in patients with dilated cardiomyopathy. CIRCULATION, 108(17), 412–412. -
Reduced myocardial brain natriuretic peptide expression and collagen deposition following ventricular assist device support for heart failure
Fenster, B. E., Fowler, M. B., Yee, Y. G., Connolly, A., & Tsao, P. S. (2003). Reduced myocardial brain natriuretic peptide expression and collagen deposition following ventricular assist device support for heart failure. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 41(6), 165A–165A. -
Relationship between tissue and circulating levels of angiotensin converting enzyme with high and low dose enalapril therapy in heart failure
Fowler, M. B., Yee, Y. G., Vagelos, R. H., Willson, K., Prikazsky, L., Mullin, A., & Waldman-Boucher, M. (1998). Relationship between tissue and circulating levels of angiotensin converting enzyme with high and low dose enalapril therapy in heart failure. CIRCULATION, 98(17), 854–854. -
Impact of angiotenisin-converting enzyme gene polymorphism on neurohormonal responses to high- versus low-dose enalapril in advanced heart failure
Tang, W. H. W., Vagelos, R. H., Yee, Y. G., & Fowler, M. B. (2004). Impact of angiotenisin-converting enzyme gene polymorphism on neurohormonal responses to high- versus low-dose enalapril in advanced heart failure. AMERICAN HEART JOURNAL, 148(5), 889–894. -
HEMODYNAMIC, RENAL, AND ENDOCRINE EFFECTS OF ATRIAL-NATRIURETIC-PEPTIDE IN SEVERE CONGESTIVE-HEART-FAILURE
Molina, C. R., Fowler, M. B., Peterson, C. A., COSTARD, A., Myers, B. D., & Murad, F. (1987). HEMODYNAMIC, RENAL, AND ENDOCRINE EFFECTS OF ATRIAL-NATRIURETIC-PEPTIDE IN SEVERE CONGESTIVE-HEART-FAILURE. CLINICAL RESEARCH, 35(3), A642–A642. -
Clinical, hemodynamic, and cardiopulmonary exercise test determinants of survival in patients referred for evaluation of heart failure
Myers, J., Gullestad, L., Vagelos, R., Do, D., Bellin, D., Ross, H., & Fowler, M. B. (1998). Clinical, hemodynamic, and cardiopulmonary exercise test determinants of survival in patients referred for evaluation of heart failure. ANNALS OF INTERNAL MEDICINE, 129(4), 286-? -
Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure
Gullestad, L., Aukrust, P., Ueland, T., Espevik, T., Yee, G., Vagelos, R., … Fowler, M. (1999). Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 34(7), 2061–2067. -
HYPOXIC PULMONARY VASOCONSTRICTION PERSISTS IN THE HUMAN TRANSPLANTED LUNG
Robin, E. D., Theodore, J., Burke, C. M., Oesterle, S. N., Fowler, M. B., Jamieson, S. W., … Shumway, N. E. (1987). HYPOXIC PULMONARY VASOCONSTRICTION PERSISTS IN THE HUMAN TRANSPLANTED LUNG. CLINICAL SCIENCE, 72(3), 283–287. -
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THE INFLUENCE OF PREOPERATIVE PATIENT CHARACTERISTICS ON EARLY AND LATE SURVIVAL FOLLOWING CARDIAC TRANSPLANTATION
COSTARDJACKLE, A., Hill, I., Schroeder, J. S., & Fowler, M. B. (1991). THE INFLUENCE OF PREOPERATIVE PATIENT CHARACTERISTICS ON EARLY AND LATE SURVIVAL FOLLOWING CARDIAC TRANSPLANTATION. CIRCULATION, 84(5), 329–337. -
EFFECT OF PREOPERATIVE HEMODYNAMIC SUPPORT ON SURVIVAL AFTER CARDIAC TRANSPLANTATION
OCONNELL, J. B., Renlund, D. G., Robinson, J. A., Fowler, M. B., Oyer, P. E., Pifarre, R., … Bristow, M. R. (1988). EFFECT OF PREOPERATIVE HEMODYNAMIC SUPPORT ON SURVIVAL AFTER CARDIAC TRANSPLANTATION. CIRCULATION, 78(5), 78–82. -
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Race and the response to adrenergic blockade with carvedilol in patients with chronic heart failure.
Yancy, C. W., Fowler, M. B., Colucci, W. S., Gilbert, E. M., Bristow, M. R., Cohn, J. N., … Packer, M. (2001). Race and the response to adrenergic blockade with carvedilol in patients with chronic heart failure. NEW ENGLAND JOURNAL OF MEDICINE, 344(18), 1358–1365. -
BENEFICIAL-EFFECTS OF METOPROLOL IN IDIOPATHIC DILATED CARDIOMYOPATHY
Waagstein, F., Bristow, M. R., Swedberg, K., Camerini, F., Fowler, M. B., Silver, M. A., … Hjalmarson, A. (1993). BENEFICIAL-EFFECTS OF METOPROLOL IN IDIOPATHIC DILATED CARDIOMYOPATHY. LANCET, 342(8885), 1441–1446. -
Are beta-blockers needed in patients receiving spironolactone for severe chronic heart failure? An analysis of the COPERNICUS study
Krum, H., Mohacsi, P., Katus, H. A., Tendera, M., Rouleau, J. L., Fowler, M. B., … Packer, M. (2006). Are beta-blockers needed in patients receiving spironolactone for severe chronic heart failure? An analysis of the COPERNICUS study. AMERICAN HEART JOURNAL, 151(1), 55–61. -
beta-Blocker therapy for heart failure outside the clinical trial setting: Findings of a community-based registry
Franciosa, J. A., Massie, B. M., Lukas, M. A., Nelson, J. J., Lottes, S., Abraham, W. T., … Greenberg, B. (2004). beta-Blocker therapy for heart failure outside the clinical trial setting: Findings of a community-based registry. AMERICAN HEART JOURNAL, 148(4), 718–726. -
Effects of initiating carvedilol in patients with severe chronic heart failure - Results from the COPERNICUS study
Krum, H., Roecker, E. B., Mohacsi, P., Rouleau, J. L., Tendera, M., COATS, A. J. S., … Packer, M. (2003). Effects of initiating carvedilol in patients with severe chronic heart failure - Results from the COPERNICUS study. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 289(6), 712–718. -
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
Packer, M., Bristow, M. R., Cohn, J. N., Colucci, W. S., Fowler, M. B., Gilbert, E. M., & Shusterman, N. H. (1996). The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. NEW ENGLAND JOURNAL OF MEDICINE, 334(21), 1349–1355. -
POOR SURVIVAL OF PATIENTS WITH IDIOPATHIC CARDIOMYOPATHY CONSIDERED TOO WELL FOR TRANSPLANTATION
Stevenson, L. W., Fowler, M. B., Schroeder, J. S., Stevenson, W. G., Dracup, K. A., & FOND, V. (1987). POOR SURVIVAL OF PATIENTS WITH IDIOPATHIC CARDIOMYOPATHY CONSIDERED TOO WELL FOR TRANSPLANTATION. AMERICAN JOURNAL OF MEDICINE, 83(5), 871–876. -
Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure
Bristow, M. R., Gilbert, E. M., Abraham, W. T., Adams, K. F., Fowler, M. B., Hershberger, R. E., … Shusterman, N. (1996). Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. CIRCULATION, 94(11), 2807–2816. -
Predictors of clinical outcomes in patients given carvedilol for heart failure
Greenberg, B., Lottes, S. R., Nelson, J. J., Lukas, M. A., Fowler, M. B., Massie, B. M., … Franciosa, J. A. (2006). Predictors of clinical outcomes in patients given carvedilol for heart failure. AMERICAN JOURNAL OF CARDIOLOGY, 98(11), 1480–1484. -
Cost effectiveness of carvedilol for heart failure
Delea, T. E., Vera-Llonch, M., Richner, R. E., Fowler, M. B., & Oster, G. (1999). Cost effectiveness of carvedilol for heart failure. AMERICAN JOURNAL OF CARDIOLOGY, 83(6), 890–896. -
Effect of carvedilol on the morbidity of patients with severe chronic heart failure - Results of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study
Packer, M., Fowler, M. B., Roecker, E. B., COATS, A. J. S., Katus, H. A., Krum, H., … DeMets, D. L. (2002). Effect of carvedilol on the morbidity of patients with severe chronic heart failure - Results of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study. CIRCULATION, 106(17), 2194–2199. -
Physical activity patterns and exercise performance in cardiac transplant recipients.
Myers, J., Gullestad, L., Bellin, D., Ross, H., Vagelos, R., & Fowler, M. (2003). Physical activity patterns and exercise performance in cardiac transplant recipients. Journal of Cardiopulmonary Rehabilitation, 23(2), 100–106. -
Comparison of outcomes and usefulness of carvedilol across a spectrum of left ventricular ejection fractions in patients with heart failure in clinical practice
Massie, B. M., Nelson, J. J., Lukas, M. A., Greenberg, B., Fowler, M. B., Gilbert, E. M., … Franciosa, J. A. (2007). Comparison of outcomes and usefulness of carvedilol across a spectrum of left ventricular ejection fractions in patients with heart failure in clinical practice. AMERICAN JOURNAL OF CARDIOLOGY, 99(9), 1263–1268. -
HEMODYNAMIC AND RENAL EFFECTS OF ATRIAL-NATRIURETIC-PEPTIDE IN CONGESTIVE HEART-FAILURE
Fifer, M. A., Molina, C. R., QUIROZ, A. C., Giles, T. D., Herrmann, H. C., DESCHEERDER, I. R., … Fowler, M. B. (1990). HEMODYNAMIC AND RENAL EFFECTS OF ATRIAL-NATRIURETIC-PEPTIDE IN CONGESTIVE HEART-FAILURE. AMERICAN JOURNAL OF CARDIOLOGY, 65(3), 211–216. -
Rationale, design, and methods for a Coreg (Carvedilol) heart failure registry (COHERE)
Franciosa, J. A., Abraham, W. T., Fowler, M., Gilbert, E. M., Greenberg, B., Massie, B. M., … Nelson, J. J. (2000). Rationale, design, and methods for a Coreg (Carvedilol) heart failure registry (COHERE). JOURNAL OF CARDIAC FAILURE, 6(3), 264–271. -
Effect of carvedilol on survival in severe chronic heart failure.
Packer, M., COATS, A. J. S., Fowler, M. B., Katus, H. A., Krum, H., Mohacsi, P., … DeMets, D. L. (2001). Effect of carvedilol on survival in severe chronic heart failure. NEW ENGLAND JOURNAL OF MEDICINE, 344(22), 1651–1658. -
The effect of carvedilol on mortality risk in heart failure patients with diabetes: results of a meta-analysis
Bell, D. S. H., Lukas, M. A., Holdbrook, F. K., & Fowler, M. B. (2006). The effect of carvedilol on mortality risk in heart failure patients with diabetes: results of a meta-analysis. CURRENT MEDICAL RESEARCH AND OPINION, 22(2), 287–96. -
BETA-ADRENERGIC NEUROEFFECTOR ABNORMALITIES IN THE FAILING HUMAN HEART ARE PRODUCED BY LOCAL RATHER THAN SYSTEMIC MECHANISMS
Bristow, M. R., Minobe, W., Rasmussen, R., Larrabee, P., SKERL, L., Klein, J. W., … Ginsburg, R. (1992). BETA-ADRENERGIC NEUROEFFECTOR ABNORMALITIES IN THE FAILING HUMAN HEART ARE PRODUCED BY LOCAL RATHER THAN SYSTEMIC MECHANISMS. JOURNAL OF CLINICAL INVESTIGATION, 89(3), 803–815. -
Influence of pretreatment systolic blood pressure on the effect of carvedilol in patients with severe chronic heart failure - The Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study
Rouleau, J. L., Roecker, E. B., Tendera, M., Mohacsi, P., Krum, H., Katus, H. A., … Packer, M. (2004). Influence of pretreatment systolic blood pressure on the effect of carvedilol in patients with severe chronic heart failure - The Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 43(8), 1423–1429. -
Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure
Colucci, W. S., Packer, M., Bristow, M. R., Gilbert, E. M., Cohn, J. N., Fowler, M. B., … Lukas, M. A. (1996). Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure. CIRCULATION, 94(11), 2800–2806. -
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Influence of carvedilol on hospitalizations in heart failure: Incidence, resource utilization and costs
Fowler, M. B., Vera-Llonch, N., Oster, G., Bristow, M. R., Cohn, J. N., Colucci, W. S., … Packer, M. (2001). Influence of carvedilol on hospitalizations in heart failure: Incidence, resource utilization and costs. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(6), 1692–99. -
An informatics-based approach to reducing heart failure all-cause readmissions: the Stanford heart failure dashboard.
Banerjee, D., Thompson, C., Kell, C., Shetty, R., Vetteth, Y., Grossman, H., … Fowler, M. (2016). An informatics-based approach to reducing heart failure all-cause readmissions: the Stanford heart failure dashboard. Journal of the American Medical Informatics Association . -
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OUTCOME OF EN-BLOC COMBINED HEART AND LIVER TRANSPLANTATION IN THE ADULT FAILING FONTAN
Vaikunth, S., Concepcion, W., Daugherty, T., Fowler, M., Lutchman, G., Maeda, K., … Lui, G. K. (2018). OUTCOME OF EN-BLOC COMBINED HEART AND LIVER TRANSPLANTATION IN THE ADULT FAILING FONTAN. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 71(11), 539. -
SERIAL CARDIAC FDG-PET IN THE DIAGNOSIS AND THERAPEUTIC GUIDANCE OF PATIENTS WITH CARDIAC SARCOIDOSIS: A STANFORD EXPERIENCE
Ning, N., Guo, H. H., Jagaru, A., Mittra, E., Fowler, M., & Witteles, R. (2018). SERIAL CARDIAC FDG-PET IN THE DIAGNOSIS AND THERAPEUTIC GUIDANCE OF PATIENTS WITH CARDIAC SARCOIDOSIS: A STANFORD EXPERIENCE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 71(11), 1690. -
Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients with Cardiac Sarcoidosis.
Ning, N., Guo, H. H., Iagaru, A., Mittra, E., Fowler, M., & Witteles, R. (2019). Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients with Cardiac Sarcoidosis. Journal of Cardiac Failure. -
Short-Term Outcomes of en bloc Combined Heart and Liver Transplantation in the Failing Fontan.
Vaikunth, S. S., Concepcion, W., Daugherty, T., Fowler, M., Lutchman, G., Maeda, K., … Lui, G. K. (2019). Short-Term Outcomes of en bloc Combined Heart and Liver Transplantation in the Failing Fontan. Clinical Transplantation, e13540. -
Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis
Ning, N., Guo, H. H., Iagaru, A., Mittra, E., Fowler, M., & Witteles, R. (2019). Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis. JOURNAL OF CARDIAC FAILURE, 25(4), 307–11. -
Short-term outcomes of en bloc combined heart and liver transplantation in the failing Fontan
Vaikunth, S. S., Concepcion, W., Daugherty, T., Fowler, M., Lutchman, G., Maeda, K., … Lui, G. K. (2019). Short-term outcomes of en bloc combined heart and liver transplantation in the failing Fontan. CLINICAL TRANSPLANTATION, 33(6). -
A Changing Landscape of Mortality for Systemic Light Chain Amyloidosis.
Barrett, C. D., Dobos, K., Liedtke, M., Tuzovic, M., Haddad, F., Kobayashi, Y., … Witteles, R. M. (2019). A Changing Landscape of Mortality for Systemic Light Chain Amyloidosis. JACC. Heart Failure.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
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Mechanical Circulatory Support Program Stanford, CA
Stanford, CAMechanical Circulatory Support Program
300 Pasteur Drive, 2nd Floor, Room A260
Stanford , CA 94305
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Stanford, CAHeart Transplant Program
300 Pasteur Drive, 2nd Floor, Room A21
Stanford , CA 94305
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