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RADIOIMMUNE ASSAY OF HETEROLOGOUS SERUM GAMMA-GLOBULIN IN PATIENTS RECEIVING RABBIT ANTIHUMAN THYMOCYTE GLOBULIN TRANSPLANTATION BIEBER, C. P., Lydick, E., Griepp, R. B., David, L. A., Oyer, P. E., Stinson, E. B. 1975; 20 (5): 393-398

Abstract

A radioimmune assay (RIA) method for detecting heterologous serum rabbit gamma-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit gamma-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA.

View details for Web of Science ID A1975AW24400006

View details for PubMedID 54964