Cortical Brain Age from Pre-treatment to Post-chemotherapy in Patients with Breast Cancer. Neurotoxicity research Henneghan, A. n., Rao, V. n., Harrison, R. A., Karuturi, M. n., Blayney, D. W., Palesh, O. n., Kesler, S. R. 2020

Abstract

Chemotherapy-related cognitive impairment and associated brain changes may reflect accelerated brain aging; however, empirical evidence for this theory is limited. The purpose of this study was to measure brain aging in newly diagnosed patients with breast cancer treated with chemotherapy (n?=?43) and compare its longitudinal change to that of controls (n?=?50). Brain age indices, derived from cortical measures, were compared between women with breast cancer and matched healthy controls across 3 timepoints (time 1: pre-surgery, time 2: 1 month following chemotherapy completion, and time 3: 1-year post-chemotherapy). The breast cancer group showed a significant decrease in cortical thickness across the 3 timepoints (p?

View details for DOI 10.1007/s12640-019-00158-z

View details for PubMedID 31900898