Biography
Dr. Levine is internationally recognized for her work in lung transplantation and pulmonary hypertension (PH). She has been instrumental in developing international guidelines for defining, diagnosing, and managing antibody-mediated rejection (AMR) after lung transplantation. She has served as chair of pulmonary AMR guidelines for the International Society of Heart and Lung Transplantation.
Dr. Levine’s research interests include lung allograft monitoring and risk assessment. Her research has also included monitoring lung allograft health using donor-derived cell-free DNA (dd-cfDNA)—a technique pioneered at Stanford Medicine. She has received National Institutes of Health (NIH) funding as a clinical investigator. Dr. Levine is a co-chair of the ALAMO (AlloSure Lung Assessment and Metagenomics Outcomes) Study national registry. She has been involved in many clinical trials in lung transplantation and pulmonary hypertension.
As a respected educator and researcher, Dr. Levine has led and contributed to dozens of abstracts, presentations, and peer-reviewed articles. She has also written several books and book chapters on pulmonary hypertension, interstitial lung disease, pulmonary vascular disorders, and lung transplantation.
Dr. Levine is editor-in-chief for Advances in Pulmonary Hypertension, the quarterly journal of the Pulmonary Hypertension Association. She is an editorial board member of The Journal of Heart and Lung Transplantation and an ad hoc reviewer for several other industry journals. Dr. Levine also serves as a grant reviewer and section study reviewer for the American College of Chest Physicians and the American Society of Transplantation.
Dr . Levine is a fellow of the American College of Chest Physicians and the American Society of Transplantation. She is also the chair of the Diffuse Lung Disease and Lung Transplant Network and the incoming vice chair of the Council of Networks for the American College of Chest Physicians (CHEST).
Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Critical Care Medicine (2002)
- Board Certification: American Board of Internal Medicine, Pulmonary Disease (2001)
- Fellowship: UT Health San Antonio Pulmonary Medicine Fellowship (2003) TX
- Fellowship: UT Health San Antonio Critical Care Fellowship (2002) TX
- Fellowship: Banner Good Samaritan Medical Center (2001) AZ
- Residency: Banner Good Samaritan Regional Medical Center AZ
- Medical Education: University of Arizona College of Medicine (1996) AZ
Honors & Awards
- Chair, Advanced Lung Disease Course, American College of Chest Physicians
- Chairperson, Thoracic Community of Practice, American Society of Transplantation
- Co-Chair, Lung Transplantation Master Class, International Society for Heart and Lung Transplantation (2023)
- Co-Chair, Reiteration of the Pulmonary Antibody-Mediation Rejection Guidelines, International Society of Heart and Lung Transplantation (2023)
- Course Chair, Pulmonary Hypertension-Interstitial Lung Disease, American College of Chest Physicians (2022)
- Donor Management Course Chair, Gift of Hope, American College of Chest Physicians (2022)
- Guidelines Committee Chair, Pulmonary Hypertension-Interstitial Lung Disease, American College of Chest Physicians (2022)
- President and Chair, International Paris Lung Transplant Congress (2022)
- Transplant Grant Chair, American College of Chest Physicians (2022)
Publications
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Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation.
Levine, D. J., Glanville, A. R., Aboyoun, C., Belperio, J., Benden, C., Berry, G. J., … Zeevi, A. (2016). Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation. Journal of Heart and Lung Transplantation , 35(4), 397–406. -
Human leukocyte antigens antibodies after lung transplantation: Primary results of the HALT study
Hachem, R. R., Kamoun, M., Budev, M. M., Askar, M., Ahya, V. N., Lee, J. C., … Yusen, R. D. (2018). Human leukocyte antigens antibodies after lung transplantation: Primary results of the HALT study. AMERICAN JOURNAL OF TRANSPLANTATION, 18(9), 2285–94. -
Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR).
Roux, A., Levine, D. J., Zeevi, A., Hachem, R., Halloran, K., Halloran, P. F., … Pavlisko, E. N. (2019). Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR). American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19(1), 21–31. -
ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements.
Bermudez, C. A., Crespo, M. M., Shlobin, O. A., Cantu, E., Mazurek, J. A., Levine, D., … Mercier, O. (2021). ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. -
Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal.
Calabrese, F., Roden, A. C., Pavlisko, E., Lunardi, F., Neil, D., Adam, B., … Roux, A. (2022). Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. -
Clinical features and allograft failure rates of pulmonary antibody-mediated rejection categories.
Charya, A. V., Ponor, I. L., Cochrane, A., Levine, D., Philogene, M., Fu, Y.-P. P., … Agbor-Enoh, S. (2022). Clinical features and allograft failure rates of pulmonary antibody-mediated rejection categories. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. -
Transplant of organs from donors with positive SARS-CoV-2 nucleic acid testing: A report from the organ procurement and transplantation network ad hoc disease transmission advisory committee.
Goldman, J. D., Pouch, S. M., Woolley, A. E., Booker, S. E., Jett, C. T., Fox, C., … Danziger-Isakov, L. (2023). Transplant of organs from donors with positive SARS-CoV-2 nucleic acid testing: A report from the organ procurement and transplantation network ad hoc disease transmission advisory committee. Transplant Infectious Disease : an Official Journal of the Transplantation Society, e14013. -
A survey of intensive care unit models in cardiothoracic transplantation at high-volume centers.
Nurok, M., Nunnally, M. E., Gill, G., O'Connor, M., Harper, M., Edelman, J., … Nelson, D. (2023). A survey of intensive care unit models in cardiothoracic transplantation at high-volume centers. Clinical Transplantation, e14911. -
OPTN required SARS-CoV-2 lower respiratory testing for lung donors: Striking the balance.
Booker, S. E., Jett, C., Fox, C., Anesi, J. A., Berry, G. J., Dunn, K. E., … La Hoz, R. M. (2023). OPTN required SARS-CoV-2 lower respiratory testing for lung donors: Striking the balance. Transplant Infectious Disease : an Official Journal of the Transplantation Society, e14048. -
Guidelines and principles for the care of the cardiothoracic transplant patient in the intensive care unit.
Nurok, M., Nunnally, M. E., O'Connor, M., Pierson, R. N., Baran, D. A., Harper, M. D., … Nelson, D. (2023). Guidelines and principles for the care of the cardiothoracic transplant patient in the intensive care unit. Clinical Transplantation, e14978. -
Defining a NK cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies.
Gauthier, P. T., Mackova, M., Hirji, A., Weinkauf, J., Timofte, I. L., Snell, G. I., … Halloran, P. F. (2023). Defining a NK cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. -
Lung Transplantation Training in North America: Bridging the Gap.
Azfar Ali, H., & Levine, D. J. (2023). Lung Transplantation Training in North America: Bridging the Gap. Chest, 164(3), 580–582. -
The 2022 Banff Meeting Lung Report.
Pavlisko, E. N., Adam, B. A., Berry, G. J., Calabrese, F., Cortes-Santiago, N., Glass, C. H., … Roux, A. (2023). The 2022 Banff Meeting Lung Report. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. -
Single Center "Snapshot" Experience With Donor-Derived Cell-Free DNA After Lung Transplantation.
Levine, D. J., Ross, D. J., & Sako, E. (2020). Single Center "Snapshot" Experience With Donor-Derived Cell-Free DNA After Lung Transplantation. Biomarker Insights, 15, 1177271920958704. -
Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome-A consensus report from the Pulmonary Council of the ISHLT.
Glanville, A. R., Verleden, G. M., Todd, J. L., Benden, C., Calabrese, F., Gottlieb, J., … Snell, G. (2019). Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome-A consensus report from the Pulmonary Council of the ISHLT. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, 38(5), 483–492. -
Lung autoantibodies: Ready for prime time?
Milross, L., Hachem, R., Levine, D., & Glanville, A. R. (2017). Lung autoantibodies: Ready for prime time? The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. -
Clinical risk factors for invasive aspergillosis in lung transplant recipients: Results of an international cohort study.
Aguilar, C. A., Hamandi, B., Fegbeutel, C., Silveira, F. P., Verschuuren, E. A., Ussetti, P., … Husain, S. (2018). Clinical risk factors for invasive aspergillosis in lung transplant recipients: Results of an international cohort study. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, 37(10), 1226–1234. -
Donor-derived cell-free DNA as a composite marker of acute lung allograft dysfunction in clinical care.
Keller, M., Sun, J., Mutebi, C., Shah, P., Levine, D., Aryal, S., … Agbor-Enoh, S. (2022). Donor-derived cell-free DNA as a composite marker of acute lung allograft dysfunction in clinical care. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, 41(4), 458–466. -
Utilization of risk assessment tools in management of PAH: A PAH provider survey.
Sahay, S., Balasubramanian, V., Memon, H., Poms, A., Bossone, E., Highland, K., … Elwing, J. M. (2022). Utilization of risk assessment tools in management of PAH: A PAH provider survey. Pulmonary Circulation, 12(2), e12057. -
Incidence, Clinical Correlates, and Outcomes of Pulmonary Hypertension After Kidney Transplantation: Analysis of Linked US Registry and Medicare Billing Claims.
Lentine, K. L., Lam, N. N., Caliskan, Y., Xiao, H., Axelrod, D. A., Costa, S. P., … Villines, T. C. (2022). Incidence, Clinical Correlates, and Outcomes of Pulmonary Hypertension After Kidney Transplantation: Analysis of Linked US Registry and Medicare Billing Claims. Transplantation, 106(3), 666–675. -
Biological Variation of Donor-Derived Cell-Free DNA in Stable Lung Transplant Recipients.
Keller, M., Mutebi, C., Shah, P., Levine, D., Aryal, S., Iacono, A., … Agbor-Enoh, S. (2022). Biological Variation of Donor-Derived Cell-Free DNA in Stable Lung Transplant Recipients. The Journal of Applied Laboratory Medicine, 7(4), 901–909. -
White paper on antimicrobial stewardship in solid organ transplant recipients.
So, M., Hand, J., Forrest, G., Pouch, S. M., Te, H., Ardura, M. I., … Husain, S. (2022). White paper on antimicrobial stewardship in solid organ transplant recipients. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 22(1), 96–112. -
Acute respiratory distress syndrome in the cardiothoracic patient: State of the art and use of veno-venous extracorporeal membrane oxygenation.
Copeland, H., Levine, D., Morton, J., & Hayanga, J. W. (2021). Acute respiratory distress syndrome in the cardiothoracic patient: State of the art and use of veno-venous extracorporeal membrane oxygenation. JTCVS Open, 8, 97–103. -
Immunosuppression in Lung Transplantation.
Nelson, J., Kincaide, E., Schulte, J., Hall, R., & Levine, D. J. (2022). Immunosuppression in Lung Transplantation. Handbook of Experimental Pharmacology, 272, 139–164. -
Screening Strategies for Pulmonary Hypertension in Patients With Interstitial Lung Disease: A Multidisciplinary Delphi Study.
Rahaghi, F. F., Kolaitis, N. A., Adegunsoye, A., de Andrade, J. A., Flaherty, K. R., Lancaster, L. H., … Nathan, S. D. (2022). Screening Strategies for Pulmonary Hypertension in Patients With Interstitial Lung Disease: A Multidisciplinary Delphi Study. Chest, 162(1), 145–155. -
Chronic Lung Allograft Dysfunction is Associated with an Increased Number of Non-HLA Antibodies.
Xu, Q., Elrefaei, M., Taupin, J.-L. L., Hitchman, K. M., Hiho, S., Gareau, A., … Roux, A. (2023). Chronic Lung Allograft Dysfunction is Associated with an Increased Number of Non-HLA Antibodies. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation.
Practice Locations
Chest Clinic in Palo Alto Stanford, CA
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San Luis Obispo , CA 93401
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