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Specializing In »
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Specializing In
- Cancer Risk Assessment with Genetic Testing and Counseling
- Heritable Disease Genetic Testing
- Pathology
Biography
Dr. Merker is a clinical laboratory-based physician who specializes in genetic disease testing for both heritable disease and cancer. He is board-certified in Molecular Genetic Pathology, Clinical Pathology, and Clinical Cytogenetics. Dr. Merker is Co-Director of the Stanford Medicine Clinical Genomics Service, a laboratory section within the Stanford Anatomic Pathology & Clinical Laboratories that uses genomic sequencing and other advanced methods to evaluate the cause of disease in patients with unexplained heritable disease. He also directs an active research group that focuses on two areas: 1) development of improved experimental and computational approaches related to the use of genomic sequencing and other “omics” assays for clinical care, and 2) identification and characterization of acquired and heritable genetic variants that are important for the development of hematologic disorders and other malignancies.
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Professional Summary
Education & Certifications
- Board Certification, American Board of Medical Genetics, Clinical Cytogenetics (2011)
- Board Certification: Clinical Cytogenetics, American Board of Medical Genetics and Genomics (2011)
- Board Certification: Clinical Pathology, American Board of Pathology (2009)
- Board Certification: Molecular Genetic Pathology, American Board of Pathology (2011)
- Board Certification, American Board of Pathology, Clinical Pathology (2009)
- Board Certification, American Board of Pathology, Molecular Genetic Pathology (2011)
- Internship: Stanford Hospital and Clinics (2006) CA
- Fellowship: Stanford Hospital and Clinics (2008) CA
- Residency: Stanford Hospital and Clinics (2009) CA
- Fellowship: Stanford Hospital and Clinics (2010) CA
- Fellowship, Stanford Hospital and Clinics, Clinical Cytogenetics (2010)
- Fellowship, Stanford Hospital and Clinics, Molecular Genetic Pathology (2009)
- Residency, Stanford Hospital and Clinics, Clinical Pathology (2008)
- Postdoctoral Fellowship, Stanford University, Cancer Genomics (2012)
- Medical Education: University of North Carolina School of Medicine (2005) NC
- M.D., Ph.D., University of North Carolina School of Medicine, Medicine, Genetics (2005)
- B.S., University of North Carolina, Chapel Hill, Biology (1996)
Honors & Awards
- Alpha Omega Alpha Honor Medical Society, University of North Carolina School of Medicine (2004)
- Golden Key International Honour Society, University of North Carolina, Chapel Hill (1995)
- Phi Beta Kappa Society, University of North Carolina, Chapel Hill (1995)
Administrative Appointments
- Co-Director of the Stanford Medicine Clinical Genomics Service, Stanford Medicine (2013 - Present)
- Director of Test Development in Clinical Genomics, Stanford University School of Medicine (2013 - Present)
- Molecular Oncology Committee Chair, College of American Pathologists (2015 - Present)
- Molecular Oncology Committee Vice Chair, College of American Pathologists (2011 - 2014)
Publications
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Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult
Chiu, C. Y., Rouskin, S., Koshy, A., Urisman, A., Fischer, K., Yagi, S., … DeRisi, J. L. (2006). Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. CLINICAL INFECTIOUS DISEASES, 43(8), E71–E76. -
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Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements
Boyd, S. D., Gaeta, B. A., Jackson, K. J., Fire, A. Z., Marshall, E. L., Merker, J. D., … Collins, A. M. (2010). Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements. JOURNAL OF IMMUNOLOGY, 184(12), 6986–92. -
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia.
Ohgami, R. S., Ma, L., Merker, J. D., Martinez, B., Zehnder, J. L., & Arber, D. A. (2013). STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. Leukemia, 27(11), 2244–2247. -
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Growth of Histoplasma capsulatum isolates is better on potato dextrose agar with chloramphenicol than on brain heart infusion agar
Burtelow, M. A., Merker, J. D., & Baron, E. J. (2009). Growth of Histoplasma capsulatum isolates is better on potato dextrose agar with chloramphenicol than on brain heart infusion agar. JOURNAL DE MYCOLOGIE MEDICALE, 19(3), 197–199. -
Molecular diagnostics of non-Hodgkin lymphoma.
Merker, J. D., & Arber, D. A. (2007). Molecular diagnostics of non-Hodgkin lymphoma. Expert Opinion on Medical Diagnostics, 1(1), 47–63. -
Feasibility of using microbeads with holographic barcodes to track DNA specimens in the clinical molecular laboratory.
Merker, J. D., O'Grady, N., Gojenola, L., Dao, M., Lenta, R., Yeakley, J. M., & Schrijver, I. (2013). Feasibility of using microbeads with holographic barcodes to track DNA specimens in the clinical molecular laboratory. PeerJ, 1. -
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Clinical interpretation and implications of whole-genome sequencing.
Dewey, F. E., Grove, M. E., Pan, C., Goldstein, B. A., Bernstein, J. A., Chaib, H., … Quertermous, T. (2014). Clinical interpretation and implications of whole-genome sequencing. JAMA, 311(10), 1035–45. -
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Feasibility of using microbeads with holographic barcodes to track DNA specimens in the clinical molecular laboratory
Merker, J. D., O'Grady, N., Gojenola, L., Dao, M., Lenta, R., Yeakley, J. M., & Schrijver, I. (2013). Feasibility of using microbeads with holographic barcodes to track DNA specimens in the clinical molecular laboratory. PEERJ, 1. -
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College of American Pathologists' Laboratory Standards for Next-Generation Sequencing Clinical Tests
Aziz, N., Zhao, Q., Bry, L., Driscoll, D. K., Funke, B., Gibson, J. S., … Voelkerding, K. V. (2015). College of American Pathologists' Laboratory Standards for Next-Generation Sequencing Clinical Tests. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 139(4), 481–493. -
A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma.
Ozawa, M. G., Bhaduri, A., Chisholm, K. M., Baker, S. A., Ma, L., Zehnder, J. L., … Ohgami, R. S. (2016). A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma. Modern Pathology , 29(10), 1212–20. -
Complete response to gemtuzumab ozogamicin in a patient with refractory mast cell leukemia.
Alvarez-Twose, I., Martínez-Barranco, P., Gotlib, J., García-Montero, A., Morgado, J. M., Jara-Acevedo, M., … Orfao, A. (2016). Complete response to gemtuzumab ozogamicin in a patient with refractory mast cell leukemia. Leukemia, 30(8), 1753–1756. -
A Model Study of In Silico Proficiency Testing for Clinical Next-Generation Sequencing.
Duncavage, E. J., Abel, H. J., Merker, J. D., Bodner, J. B., Zhao, Q., Voelkerding, K. V., & Pfeifer, J. D. (2016). A Model Study of In Silico Proficiency Testing for Clinical Next-Generation Sequencing. Archives of Pathology & Laboratory Medicine, 140(10), 1085–1091.
Clinical Trials
Practice Locations
Stanford Hospital Stanford, CA
Stanford, CA
Stanford Hospital
300 - 500 Pasteur Drive
Stanford , CA 94304
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