Biography
Dr. Montine received his education at Columbia University (BA in Chemistry), the University of Rochester (PhD in Pharmacology), and McGill University (MD and CM). His postgraduate medical training was at Duke University, and he was junior faculty at Vanderbilt University where he was awarded the Thorne Professorship in Pathology. In 2002, Dr. Montine was appointed as the Alvord Endowed Professor in Neuropathology and Director of the Division of Neuropathology at the University of Washington. He was Director of the University of Washington Alzheimer’s Disease Research Center, one of the original 10 Centers in the US, and passed that responsibility to able colleagues. Dr. Montine was the founding Director of the Pacific Udall Center, a NINDS-funded Morris K. Udall Centers of Excellence for Parkinson’s Disease Research. In 2010, Dr. Montine was appointed Chair of the Department of Pathology at the University of Washington. In 2016, Dr. Montine was appointed Chair of the Department of Pathology at Stanford University where he is the Stanford Medicine Endowed Professor in Pathology.
The focus of the Montine Laboratory is on the structural and molecular bases of cognitive impairment. The Montine Laboratory addresses this prevalent, unmet medical need through a combination of neuropathology, biomarkers for detection and progression of early disease, and experimental studies that test hypotheses concerning specific mechanisms of neuron injury and then develop novel approaches to neuroprotection. Our current approaches include small molecule precision therapeutics and cell replacement strategies for brain.
The focus of the Montine Laboratory is on the structural and molecular bases of cognitive impairment. The Montine Laboratory addresses this prevalent, unmet medical need through a combination of neuropathology, biomarkers for detection and progression of early disease, and experimental studies that test hypotheses concerning specific mechanisms of neuron injury and then develop novel approaches to neuroprotection. Our current approaches include small molecule precision therapeutics and cell replacement strategies for brain.
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Professional Summary
Education & Certifications
- Board Certification: American Board of Pathology, Neuropathology (1997)
- Board Certification: American Board of Pathology, Anatomic Pathology (1997)
- Residency: Duke University Hospital (1995) NC
- Residency: Duke University Hospital (1994) NC
- Internship: Duke University Medical Center (1992) NC
- Medical Education: McGill University Faculty of Medicine (1991) Canada
Administrative Appointments
- Department Chair, Stanford University Department of Pathology (2016 - Present)
Publications
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Mutations in Prickle Orthologs Cause Seizures in Flies, Mice, and Humans
Tao, H., Manak, J. R., Sowers, L., Mei, X., Kiyonari, H., Abe, T., … Bassuk, A. G. (2011). Mutations in Prickle Orthologs Cause Seizures in Flies, Mice, and Humans. AMERICAN JOURNAL OF HUMAN GENETICS, 88(2), 138–49. -
Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease
Shi, J., Wang, Q., Johansson, J. U., Liang, X., Woodling, N. S., Priyam, P., … Andreasson, K. (2012). Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease. ANNALS OF NEUROLOGY, 72(5), 788–98. -
The future of blood-based biomarkers for Alzheimer's disease
Henriksen, K., O'Bryant, S. E., Hamper, H., Trojanowski, J. Q., Montine, T. J., Jeromin, A., … Weiner, M. W. (2014). The future of blood-based biomarkers for Alzheimer's disease. ALZHEIMERS & DEMENTIA, 10(1), 115–31. -
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Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential
Johnston, J. M., Hu, W. T., Fardo, D. W., Greco, S. J., Perry, G., Montine, T. J., … Tezapsidis, N. (2014). Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential. CURRENT ALZHEIMER RESEARCH, 11(2), 165–174. -
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Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis
Irwin, D., Grossman, M., Weintraub, D., Hurtig, H. I., Duda, J. E., Xie, S. X., … Trojanowski, J. Q. (2017). Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. LANCET NEUROLOGY, 16(1), 55–65. -
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015
Wang, H., Naghavi, M., Allen, C., Barber, R. M., Bhutta, Z. A., Carter, A., … Murray, C. J. L. (2016). Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. LANCET, 388(10053), 1459–1544. -
Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.
Zahratka, J. A., Shao, Y., Shaw, M. K., Todd, K., Formica, S. V., Khrestian, M., … Bekris, L. M. (2017). Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease. Neurobiology of Aging, 51, 43–53. -
Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease.
Flanagan, M. E., Marshall, D. A., Shofer, J. B., Montine, K. S., Nelson, P. T., Montine, T. J., & Keene, C. D. (2017). Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease. Journal of Neuropathology and Experimental Neurology. -
Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE e4.
Postupna, N., Latimer, C. S., Larson, E. B., Sherfield, E., Paladin, J., Shively, C. A., … Montine, T. J. (2017). Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE e4. American Journal of Pathology. -
Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
Jun, G. R., Chung, J., Mez, J., Barber, R., Beecham, G. W., Bennett, D. A., … Farrer, L. A. (2017). Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. -
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Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies.
Latimer, C. S., Keene, C. D., Flanagan, M. E., Hemmy, L. S., Lim, K. O., White, L. R., … Montine, T. J. (2017). Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies. Journal of Neuropathology and Experimental Neurology, 76(6), 458–66. -
Use of Analgesics (Opioids and Nonsteroidal Anti-Inflammatory Drugs) and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort.
Dublin, S., Walker, R. L., Gray, S. L., Hubbard, R. A., Anderson, M. L., Yu, O., … Larson, E. B. (2017). Use of Analgesics (Opioids and Nonsteroidal Anti-Inflammatory Drugs) and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. Journal of Alzheimer's Disease : JAD, 58(2), 435–48. -
Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial
Craft, S., Claxton, A., Baker, L. D., Hanson, A. J., Cholerton, B., Trittschuh, E. H., … Friedman, S. (2017). Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial. JOURNAL OF ALZHEIMERS DISEASE, 57(4), 1325–34. -
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues.
Corces, M. R., Trevino, A. E., Hamilton, E. G., Greenside, P. G., Sinnott-Armstrong, N. A., Vesuna, S., … Chang, H. Y. (2017). An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nature Methods. -
Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease.
Cholerton, B., Johnson, C. O., Fish, B., Quinn, J. F., Chung, K. A., Peterson-Hiller, A. L., … Edwards, K. L. (2018). Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease. Parkinsonism & Related Disorders. -
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Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium
McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J.-P., Weintraub, D., … Kosaka, K. (2017). Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium. NEUROLOGY, 89(1), 88–100. -
Comparison of regional flortaucipir PET SUVr values to quantitative tau histology and quantitative tau immunoassay in patients with Alzheimer's disease pathology: A clinicopathological study
Siderowf, A., Keene, C., Beach, T., Montine, T., Arora, A., Devous, M., … Mintun, M. (2017). Comparison of regional flortaucipir PET SUVr values to quantitative tau histology and quantitative tau immunoassay in patients with Alzheimer's disease pathology: A clinicopathological study. JOURNAL OF NUCLEAR MEDICINE. SOC NUCLEAR MEDICINE INC. -
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Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau
Hohman, T. J., Dumitrescu, L., Barnes, L. L., Thambisetty, M., Beecham, G., Kunkle, B., … Jefferson, A. L. (2018). Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA NEUROLOGY, 75(8), 989–98. -
Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study
Bettcher, B. M., Ard, M. C., Reed, B. R., Benitez, A., Simmons, A., Larson, E. B., … Mungas, D. (2017). Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study. JOURNAL OF ALZHEIMERS DISEASE, 59(4), 1307–15. -
Exposure to Strong Anticholinergic Medications and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort
Gray, S. L., Anderson, M. L., Hanlon, J. T., Dublin, S., Walker, R. L., Hubbard, R. A., … Larson, E. B. (2018). Exposure to Strong Anticholinergic Medications and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. JOURNAL OF ALZHEIMERS DISEASE, 65(2), 607–16. -
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Mass synaptometry: High-dimensional multi parametric assay for single synapses.
Gajera, C. R., Fernandez, R., Postupna, N., Montine, K. S., Fox, E. J., Tebaykin, D., … Montine, T. J. (2018). Mass synaptometry: High-dimensional multi parametric assay for single synapses. Journal of Neuroscience Methods. -
A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.
Latimer, C. S., Shively, C. A., Keene, C. D., Jorgensen, M. J., Andrews, R. N., Register, T. C., … Craft, S. (2018). A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. -
Sex-specific genetic predictors of Alzheimer's disease biomarkers
Deming, Y., Dumitrescu, L., Barnes, L. L., Thambisetty, M., Kunkle, B., Gifford, K. A., … Hohman, T. J. (2018). Sex-specific genetic predictors of Alzheimer's disease biomarkers. ACTA NEUROPATHOLOGICA, 136(6), 857–72. -
"Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia".
Jagust, W., Jack, C. R., Bennett, D. A., Blennow, K., Haeberlein, S. B., Holtzman, D. M., … Sperling, R. (2019). "Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia". Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 15(1), 153–57. -
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Primum non nocere: a call for balance when reporting on CTE.
Stewart, W., Allinson, K., Al-Sarraj, S., Bachmeier, C., Barlow, K., Belli, A., … Smith, D. H. (2019). Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology, 18(3), 231–33. -
Concepts for brain aging: resistance, resilience, reserve, and compensation.
Montine, T. J., Cholerton, B. A., Corrada, M. M., Edland, S. D., Flanagan, M. E., Hemmy, L. S., … White, L. R. (2019). Concepts for brain aging: resistance, resilience, reserve, and compensation. Alzheimer's Research & Therapy, 11(1), 22. -
Cognitive Performance in Parkinson's Disease in the Brain Health Registry.
Cholerton, B., Weiner, M. W., Nosheny, R. L., Poston, K. L., Scott Mackin, R., Tian, L., … Montine, T. J. (2019). Cognitive Performance in Parkinson's Disease in the Brain Health Registry. Journal of Alzheimer's Disease : JAD. -
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
Chauhan, G., Adams, H. H. H., Satizabal, C. L., Bis, J. C., Teumer, A., Sargurupremraj, M., … Debette, S. (2019). Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. NEUROLOGY, 92(5), E486–E503. -
Type 2 diabetes and later cognitive function in older American Indians: The Strong Heart Study.
Cholerton, B., Omidpanah, A., Verney, S. P., Nelson, L. A., Baker, L. D., Suchy-Dicey, A., … Buchwald, D. (2019). Type 2 diabetes and later cognitive function in older American Indians: The Strong Heart Study. International Journal of Geriatric Psychiatry. -
Flow Cytometric Evaluation of Crude Synaptosome Preparation as a Way to Study Synaptic Alteration in Neurodegenerative Diseases
Postupna, N. O., Latimer, C. S., Keene, C. D., Montine, K. S., Montine, T. J., & Darvas, M. (2018). Flow Cytometric Evaluation of Crude Synaptosome Preparation as a Way to Study Synaptic Alteration in Neurodegenerative Diseases. SYNAPTOSOMES, 141, 297–310. -
Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults.
Li, G., Shofer, J. B., Petrie, E. C., Yu, C.-E. E., Wilkinson, C. W., Figlewicz, D. P., … Peskind, E. R. (2017). Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults. Alzheimer's Research & Therapy, 9(1), 48. -
Cerebrospinal Fluid Total Tau is Increased in Normal Pressure Hydrocephalus Patients who Undergo Successful Lumbar Drain Trials.
Baird, G., Montine, T. J., Chang, J. J., Hu, S.-C. C., & Avellino, A. M. (2017). Cerebrospinal Fluid Total Tau is Increased in Normal Pressure Hydrocephalus Patients who Undergo Successful Lumbar Drain Trials. Cureus, 9(5), e1265. -
Alzheimer's Disease Sequencing Project discovery and replication criteria for cases and controls: Data from a community-based prospective cohort study with autopsy follow-up.
Crane, P. K., Foroud, T., Montine, T. J., & Larson, E. B. (2017). Alzheimer's Disease Sequencing Project discovery and replication criteria for cases and controls: Data from a community-based prospective cohort study with autopsy follow-up. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 13(12), 1410–1413. -
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., … Schneider, J. A. (2019). Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain : a Journal of Neurology. -
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Effect of dopaminergic medications on BOLD variability and functional connectivity in Parkinson's disease.
Day, T. K., Madhyastha, T. M., Lee, A., Zabetian, C. P., Montine, T. J., & Grabowski, T. (2019). Effect of dopaminergic medications on BOLD variability and functional connectivity in Parkinson's disease. Brain Connectivity. -
Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson's disease.
Specketer, K., Zabetian, C. P., Edwards, K. L., Tian, L., Quinn, J. F., Peterson-Hiller, A. L., … Cholerton, B. A. (2019). Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 1–11. -
Type 2 diabetes and later cognitive function in older American Indians: The Strong Heart Study
Cholerton, B., Omidpanah, A., Verney, S. P., Nelson, L. A., Baker, L. D., Suchy-Dicey, A., … Buchwald, D. (2019). Type 2 diabetes and later cognitive function in older American Indians: The Strong Heart Study. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 34(7), 1050–57. -
Validation and Clinical Use of Whole Slide Digital Imaging at Stanford Neuropathology
Lavezo, J., Born, D., Lummus, S., Young, A., Montine, T., & Vogel, H. (2019). Validation and Clinical Use of Whole Slide Digital Imaging at Stanford Neuropathology. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
Reply: LATE to the PART-y.
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., … Schneider, J. A. (2019). Reply: LATE to the PART-y. Brain : a Journal of Neurology. -
Comparative sensitivity of the MoCA and Mattis Dementia Rating Scale-2 in Parkinson's disease
Hendershott, T. R., Zhu, D., Llanes, S., Zabetian, C. P., Quinn, J., Edwards, K. L., … Poston, K. L. (2019). Comparative sensitivity of the MoCA and Mattis Dementia Rating Scale-2 in Parkinson's disease. MOVEMENT DISORDERS, 34(2), 285–91. -
Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease
Cholerton, B., Johnson, C. O., Fish, B., Quinn, J. F., Chung, K. A., Peterson-Hiller, A. L., … Edwards, K. L. (2018). Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease. PARKINSONISM & RELATED DISORDERS, 50, 29–36. -
Concepts for brain aging: resistance, resilience, reserve, and compensation
Montine, T. J., Cholerton, B. A., Corrada, M. M., Edland, S. D., Flanagan, M. E., Hemmy, L. S., … White, L. R. (2019). Concepts for brain aging: resistance, resilience, reserve, and compensation. ALZHEIMERS RESEARCH & THERAPY, 11. -
TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study
Flanagan, M. E., Cholerton, B., Latimer, C. S., Hemmy, L. S., Edland, S. D., Montine, K. S., … Montine, T. J. (2018). TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study. JOURNAL OF ALZHEIMERS DISEASE, 66(4), 1549–58. -
TDP43 associations in the Nun Study and Honolulu Asian Aging Study
Flanagan, M., Hemmy, L., Cholerton, B., Edland, S., Montine, K., White, L., & Montine, T. (2017). TDP43 associations in the Nun Study and Honolulu Asian Aging Study. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
The basis of cellular and regional vulnerability in Alzheimer's disease.
Mrdjen, D., Fox, E. J., Bukhari, S. A., Montine, K. S., Bendall, S. C., & Montine, T. J. (2019). The basis of cellular and regional vulnerability in Alzheimer's disease. Acta Neuropathologica. -
Association Between Sepsis and Microvascular Brain Injury.
Ehlenbach, W. J., Sonnen, J. A., Montine, T. J., & Larson, E. B. (2019). Association Between Sepsis and Microvascular Brain Injury. Critical Care Medicine. -
Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease.
Young, J. I., Sivasankaran, S. K., Wang, L., Ali, A., Mehta, A., Davis, D. A., … Vance, J. M. (2019). Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease. Neurology. Genetics, 5(4), e342. -
Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer's Disease.
Higginbotham, L., Dammer, E. B., Duong, D. M., Modeste, E., Montine, T. J., Lah, J. J., … Seyfried, N. T. (2019). Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer's Disease. Proteomes, 7(3). -
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., … Schneider, J. A. (2019). Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. BRAIN, 142, 1503–27. -
Mass synaptometry: High-dimensional multi parametric assay for single synapses
Gajera, C. R., Fernandez, R., Postupna, N., Montine, K. S., Fox, E. J., Tebaykin, D., … Montine, T. J. (2019). Mass synaptometry: High-dimensional multi parametric assay for single synapses. JOURNAL OF NEUROSCIENCE METHODS, 312, 73–83. -
Sex differences in the genetic predictors of Alzheimer's pathology.
Dumitrescu, L., Barnes, L. L., Thambisetty, M., Beecham, G., Kunkle, B., Bush, W. S., … Hohman, T. J. (2019). Sex differences in the genetic predictors of Alzheimer's pathology. Brain : a Journal of Neurology, 142(9), 2581–89. -
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Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.
Simuni, T., Uribe, L., Cho, H. R., Caspell-Garcia, C., Coffey, C. S., Siderowf, A., … Marek, K. (2019). Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study. The Lancet. Neurology. -
Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease.
Morris, R., Martini, D. N., Smulders, K., Kelly, V. E., Zabetian, C. P., Poston, K., … Horak, F. (2019). Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease. Parkinsonism & Related Disorders, 69, 104–10. -
The Associations Among Sociocultural Factors and Neuropsychological Functioning in Older American Indians: The Strong Heart Study
Verney, S. P., Suchy-Dicey, A. M., Cholerton, B., Calhoun, D., Nelson, L., Montine, T. J., … Buchwald, D. (2019). The Associations Among Sociocultural Factors and Neuropsychological Functioning in Older American Indians: The Strong Heart Study. NEUROPSYCHOLOGY, 33(8), 1078–88. -
Cognitive Correlates of MRI-defined Cerebral Vascular Injury and Atrophy in Elderly American Indians: The Strong Heart Study.
Suchy-Dicey, A., Shibata, D., Cholerton, B., Nelson, L., Calhoun, D., Ali, T., … Verney, S. P. (2019). Cognitive Correlates of MRI-defined Cerebral Vascular Injury and Atrophy in Elderly American Indians: The Strong Heart Study. Journal of the International Neuropsychological Society : JINS, 1–13. -
Participant and Study Partner Reported Impact of Cognition on Functional Activities in Parkinson's Disease
Cholerton, B., Poston, K. L., Tian, L., Quinn, J. F., Chung, K. A., Hiller, A. L., … Zabetian, C. P. (2020). Participant and Study Partner Reported Impact of Cognition on Functional Activities in Parkinson's Disease. MOVEMENT DISORDERS CLINICAL PRACTICE, 7(1), 61–69. -
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Reiman, E. M., Arboleda-Velasquez, J. F., Quiroz, Y. T., Huentelman, M. J., Beach, T. G., Caselli, R. J., … Jun, G. R. (2020). Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications, 11(1), 667. -
Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau.
Wilson, E. N., Swarovski, M. S., Linortner, P., Shahid, M., Zuckerman, A. J., Wang, Q., … Andreasson, K. I. (2020). Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau. Brain : a Journal of Neurology. -
Primum non nocere: a call for balance when reporting on CTE
Stewart, W., Allinson, K., Al-Sarraj, S., Bachmeier, C., Barlow, K., Belli, A., … Smith, D. H. (2019). Primum non nocere: a call for balance when reporting on CTE. LANCET NEUROLOGY, 18(3), 231–33. -
Impact of a deep learning assistant on the histopathologic classification of liver cancer.
Kiani, A., Uyumazturk, B., Rajpurkar, P., Wang, A., Gao, R., Jones, E., … Shen, J. (2020). Impact of a deep learning assistant on the histopathologic classification of liver cancer. NPJ Digital Medicine, 3, 23. -
Flow cytometric evaluation of crude synaptosome preparation as a way to study synaptic alteration in neurodegenerative diseases.
Postupna, N. O., Latimer, C. S., Keene, C. D., Montine, K. S., Montine, T. J., & Darvas, M. (2018). Flow cytometric evaluation of crude synaptosome preparation as a way to study synaptic alteration in neurodegenerative diseases. Neuromethods, 141, 297–310. -
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.
Johnson, E. C., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., … Seyfried, N. T. (2020). Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. -
Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes.
Fleisher, A. S., Pontecorvo, M. J., Devous, M. D., Lu, M., Arora, A. K., Truocchio, S. P., … Mintun, M. A. (2020). Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes. JAMA Neurology. -
Prediction of cognitive progression in Parkinson's disease using three cognitive screening measures.
Kim, H. M., Nazor, C., Zabetian, C. P., Quinn, J. F., Chung, K. A., Hiller, A. L., … Cholerton, B. (2019). Prediction of cognitive progression in Parkinson's disease using three cognitive screening measures. Clinical Parkinsonism & Related Disorders, 1, 91–97. -
Attention Network Test fMRI data for participants with Parkinson's disease and healthy elderly.
Day, T. K., Madhyastha, T. M., Askren, M. K., Boord, P., Montine, T. J., & Grabowski, T. J. (2019). Attention Network Test fMRI data for participants with Parkinson's disease and healthy elderly. F1000Research, 8, 780. -
Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study.
Pontecorvo, M. J., Keene, C. D., Beach, T. G., Montine, T. J., Arora, A. K., Devous, M. D., … Siderowf, A. (2020). Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study. EJNMMI Research, 10(1), 65. -
Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson's disease.
Rane, S., Koh, N., Oakley, J., Caso, C., Zabetian, C. P., Cholerton, B., … Grabowski, T. (2020). Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson's disease. Parkinsonism & Related Disorders, 76, 21–28. -
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing
Scharenberg, S. G., Poletto, E., Lucot, K. L., Colella, P., Sheikali, A., Montine, T. J., … Gomez-Ospina, N. (2020). Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing. Nature Communications, 11. -
Hallucinations and Development of Dementia in Parkinson's Disease.
Gryc, W., Roberts, K. A., Zabetian, C. P., Weintraub, D., Trojanowski, J. Q., Quinn, J. F., … Cholerton, B. A. (2020). Hallucinations and Development of Dementia in Parkinson's Disease. Journal of Parkinson's Disease. -
APOE epsilon 4-related differences in visuospatial impairment in female Parkinson's Disease patients
Rawls, A., Yang, L., Chung, K., Hiller, A., Espay, A., Revilla, F., … Cholerton, B. (2020). APOE epsilon 4-related differences in visuospatial impairment in female Parkinson's Disease patients. NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Author Correction: Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Scharenberg, S. G., Poletto, E., Lucot, K. L., Colella, P., Sheikali, A., Montine, T. J., … Gomez-Ospina, N. (2020). Author Correction: Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing. Nature Communications, 11(1), 4231. -
Multivariate prediction of dementia in Parkinson's disease.
Phongpreecha, T., Cholerton, B., Mata, I. F., Zabetian, C. P., Poston, K. L., Aghaeepour, N., … Montine, T. J. (2020). Multivariate prediction of dementia in Parkinson's disease. NPJ Parkinson's Disease, 6, 20. -
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies.
Parker, K. R., Migliorini, D., Perkey, E., Yost, K. E., Bhaduri, A., Bagga, P., … Satpathy, A. T. (2020). Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies. Cell. -
Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns.
Asher, D. M., Belay, E., Bigio, E., Brandner, S., Brubaker, S. A., Caughey, B., … Frosch, M. P. (2020). Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. Journal of Neuropathology and Experimental Neurology. -
Sensorimotor Inhibition and Mobility in Genetic Subgroups of Parkinson's Disease.
Martini, D. N., Morris, R., Kelly, V. E., Hiller, A., Chung, K. A., Hu, S.-C. C., … Horak, F. (2020). Sensorimotor Inhibition and Mobility in Genetic Subgroups of Parkinson's Disease. Frontiers in Neurology, 11, 893. -
Visualizing innate immune activation in a mouse model of Parkinson's disease using a highly specific TREM1-PET tracer.
Lucot, K., Stevens, M., Jain, P., Bonham, T., Webber, E., Klockow, J., … James, M. (2020). Visualizing innate immune activation in a mouse model of Parkinson's disease using a highly specific TREM1-PET tracer. JOURNAL OF NUCLEAR MEDICINE. SOC NUCLEAR MEDICINE INC. -
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.
Kunkle, B. W., Schmidt, M., Klein, H.-U., Naj, A. C., Hamilton-Nelson, K. L., Larson, E. B., … Kukull, W. A. (2020). Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurology. -
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases.
Corces, M. R., Shcherbina, A., Kundu, S., Gloudemans, M. J., Fresard, L., Granja, J. M., … Montine, T. J. (2020). Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases. Nature Genetics. -
Single-cell peripheral immunoprofiling of Alzheimer's and Parkinson's diseases.
Phongpreecha, T., Fernandez, R., Mrdjen, D., Culos, A., Gajera, C. R., Wawro, A. M., … Montine, T. J. (2020). Single-cell peripheral immunoprofiling of Alzheimer's and Parkinson's diseases. Science Advances, 6(48). -
Relationship between Sensorimotor Inhibition and Mobility in Older Adults with and without Parkinson's Disease.
Martini, D. N., Morris, R., Madhyastha, T. M., Grabowski, T. J., Oakley, J., Hu, S.-C., … Horak, F. B. (2020). Relationship between Sensorimotor Inhibition and Mobility in Older Adults with and without Parkinson's Disease. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. -
Cognitive Impairment in Older Adults and Therapeutic Strategies.
Montine, T. J., Bukhari, S. A., & White, L. R. (2021). Cognitive Impairment in Older Adults and Therapeutic Strategies. Pharmacological Reviews, 73(1), 152–62. -
Creatine transport and pathological changes in creatine transporter deficient mice.
Wawro, A. M., Gajera, C. R., Baker, S. A., Nirschl, J. J., Vogel, H., & Montine, T. J. (2021). Creatine transport and pathological changes in creatine transporter deficient mice. Journal of Inherited Metabolic Disease. -
Genetic Insights into Alzheimer's Disease.
Latimer, C. S., Lucot, K. L., Keene, C. D., Cholerton, B., & Montine, T. J. (2021). Genetic Insights into Alzheimer's Disease. Annual Review of Pathology, 16, 351–76. -
Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation.
Baker, S. A., Kwok, S., Berry, G. J., & Montine, T. J. (2021). Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation. PloS One, 16(2), e0247060. -
Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease.
Palmer, W. C., Cholerton, B. A., Zabetian, C. P., Montine, T. J., Grabowski, T. J., & Rane, S. (2020). Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease. Frontiers in Neurology, 11, 594213. -
Impact of a deep learning assistant on the histopathologic classification of liver cancer.
Kiani, A., Uyumazturk, B., Rajpurkar, P., Wang, A., Gao, R., Jones, E., … Shen, J. (2020). Impact of a deep learning assistant on the histopathologic classification of liver cancer. NPJ Digital Medicine, 3(1), 23. -
Cognition at Each Stage of Lewy Body Disease with Co-occurring Alzheimer's Disease Pathology.
Ryman, S. G., Yutsis, M., Tian, L., Henderson, V. W., Montine, T. J., Salmon, D. P., … Poston, K. L. (2021). Cognition at Each Stage of Lewy Body Disease with Co-occurring Alzheimer's Disease Pathology. Journal of Alzheimer's Disease : JAD. -
COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI).
Smith, D. H., Dolle, J.-P., Ameen-Ali, K. E., Bretzin, A., Cortes, E., Crary, J. F., … Stewart, W. (2021). COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathologica Communications, 9(1), 32. -
Establishing a Data Science Unit in an Academic Medical Center: An Illustrative Model.
Desai, M., Boulos, M., Pomann, G. M., Steinberg, G. K., Longo, F. M., Leonard, M., … Harrington, R. A. (2021). Establishing a Data Science Unit in an Academic Medical Center: An Illustrative Model. Academic Medicine : Journal of the Association of American Medical Colleges. -
The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample.
Postupna, N., Rose, S. E., Gibbons, L. E., Coleman, N. M., Hellstern, L. L., Ritchie, K., … Keene, C. D. (2021). The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample. Frontiers in Neurology, 12, 624696. -
Mass-tag barcoding for multiplexed analysis of human synaptosomes and other anuclear events.
Gajera, C. R., Fernandez, R., Montine, K. S., Fox, E. J., Mrdjen, D., Postupna, N. O., … Montine, T. J. (2021). Mass-tag barcoding for multiplexed analysis of human synaptosomes and other anuclear events. Cytometry. Part A : the Journal of the International Society for Analytical Cytology. -
Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus).
Frye, B. M., Craft, S., Latimer, C. S., Keene, C. D., Montine, T. J., Register, T. C., … Shively, C. A. (2021). Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus). American Journal of Primatology, e23260. -
Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior.
Wawro, A. M., Gajera, C. R., Baker, S. A., Lesniak, R. K., Fischer, C. R., Saw, N. L., … Montine, T. J. (2021). Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior. Scientific Reports, 11(1), 8138. -
Development of a Sensitive Diagnostic Assay for Parkinson Disease Quantifying alpha-Synuclein-Containing Extracellular Vesicles.
Hong, Z., Tian, C., Stewart, T., Aro, P., Soltys, D., Bercow, M., … Zhang, J. (2021). Development of a Sensitive Diagnostic Assay for Parkinson Disease Quantifying alpha-Synuclein-Containing Extracellular Vesicles. Neurology, 96(18), e2332–e2345. -
Gender Differences in the Assessment of Depression in American Indian Older Adults: The Strong Heart Study
Barbosa-Leiker, C., Burduli, E., Arias-Losado, R., Muller, C., Noonan, C., Suchy-Dicey, A., … Buchwald, D. (2021). Gender Differences in the Assessment of Depression in American Indian Older Adults: The Strong Heart Study. PSYCHOLOGICAL ASSESSMENT, 33(6), 574–579. -
Enantiomers of 4-aminopentanoic acid act as false GABAergic neurotransmitters and impact mouse behavior.
Wawro, A. M., Gajera, C. R., Baker, S. A., Lesniak, R. K., Montine, K. S., Fischer, C. R., … Montine, T. J. (2021). Enantiomers of 4-aminopentanoic acid act as false GABAergic neurotransmitters and impact mouse behavior. Journal of Neurochemistry. -
Mapping of SARS-CoV-2 Brain Invasion in COVID-19 Disease
Serrano, G., Walkera, J., Arce, R., Glass, M., Vargas, D., Sue, L., … Beach, T. (2021). Mapping of SARS-CoV-2 Brain Invasion in COVID-19 Disease. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
Brain Histopathology in Subjects with COVID-19 Disease
Beach, T., Dickson, D., Deture, M., Walker, J., Arce, R., Glass, M., … Serrano, G. (2021). Brain Histopathology in Subjects with COVID-19 Disease. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
Semantic fluency and processing speed are reduced in non-cognitively impaired participants with Parkinson's disease.
Cholerton, B. A., Poston, K. L., Yang, L., Rosenthal, L. S., Dawson, T. M., Pantelyat, A., … Zabetian, C. P. (2021). Semantic fluency and processing speed are reduced in non-cognitively impaired participants with Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 1–12. -
Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease.
Wang, X., Zhou, X., Uberseder, B., Lee, J., Latimer, C. S., Furdui, C. M., … Ma, T. (2021). Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease. Neurobiology of Disease, 105463. -
A metabolomic aging clock using human CSF.
Hwangbo, N., Zhang, X., Raftery, D., Gu, H., Hu, S.-C., Montine, T. J., … Franks, A. (2021). A metabolomic aging clock using human CSF. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. -
GATM and GAMT synthesize creatine locally throughout the mammalian body and within oligodendrocytes of the brain.
Baker, S. A., Gajera, C. R., Wawro, A. M., Corces, M. R., & Montine, T. J. (2021). GATM and GAMT synthesize creatine locally throughout the mammalian body and within oligodendrocytes of the brain. Brain Research, 147627. -
Multivariate prediction of dementia in Parkinson's disease.
Phongpreecha, T., Cholerton, B., Mata, I. F., Zabetian, C. P., Poston, K. L., Aghaeepour, N., … Montine, T. J. (2020). Multivariate prediction of dementia in Parkinson's disease. NPJ Parkinson's Disease, 6(1), 20. -
Diet Effects on Cerebrospinal Fluid Amino Acids Levels in Adults with Normal Cognition and Mild Cognitive Impairment.
Russin, K. J., Nair, K. S., Montine, T. J., Baker, L. D., & Craft, S. (2021). Diet Effects on Cerebrospinal Fluid Amino Acids Levels in Adults with Normal Cognition and Mild Cognitive Impairment. Journal of Alzheimer's Disease : JAD. -
Genome-wide association study and functional validation implicates JADE1 in tauopathy.
Farrell, K., Kim, S. H., Han, N., Iida, M. A., Gonzalez, E. M., Otero-Garcia, M., … Crary, J. F. (2021). Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. -
Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease.
Hubbard, E. E., Heil, L. R., Merrihew, G. E., Chhatwal, J. P., Farlow, M. R., McLean, C. A., … Julian, R. R. (2021). Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease. Journal of Proteome Research. -
Single-synapse analyses of Alzheimer's disease implicate pathologic tau, DJ1, CD47, and ApoE.
Phongpreecha, T., Gajera, C. R., Liu, C. C., Vijayaragavan, K., Chang, A. L., Becker, M., … Montine, T. J. (1800). Single-synapse analyses of Alzheimer's disease implicate pathologic tau, DJ1, CD47, and ApoE. Science Advances, 7(51), eabk0473. -
Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with invivo efficacy.
Lesniak, R. K., Nichols, R. J., Schonemann, M., Zhao, J., Gajera, C. R., Fitch, W. L., … Montine, T. J. (1800). Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with invivo efficacy. European Journal of Medicinal Chemistry, 229, 114080. -
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
Cogo, S., Ho, F. Y., Tosoni, E., Tomkins, J. E., Tessari, I., Iannotta, L., … Greggio, E. (1800). The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation. Brain Research, 147781. -
Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum Disorders.
Napolioni, V., Fredericks, C. A., Kim, Y., Channappa, D., Khan, R. R., Kim, L. H., … Greicius, M. D. (1800). Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum Disorders. Biomedicines, 10(1). -
Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility.
Meijer, M., Agirre, E., Kabbe, M., van Tuijn, C. A., Heskol, A., Zheng, C., … Castelo-Branco, G. (1800). Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility. Neuron. -
Mass Synaptometry: Applying Mass Cytometry to Single Synapse Analysis.
Gajera, C. R., Fernandez, R., Postupna, N., Montine, K. S., Keene, C. D., Bendall, S. C., & Montine, T. J. (1800). Mass Synaptometry: Applying Mass Cytometry to Single Synapse Analysis. Methods in Molecular Biology (Clifton, N.J.), 2417, 69–88. -
Neuropathologic lesions and comorbidity in Alzheimer disease and related dementias in a heterogeneous clinical population.
Godrich, D., Richeson, P., Schellenberg, G. D., Scott, W. K., Montine, T. J., & Beecham, G. W. (1800). Neuropathologic lesions and comorbidity in Alzheimer disease and related dementias in a heterogeneous clinical population. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 17 Suppl 3, e056249. -
Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population.
Godrich, D., Martin, E. R., Schellenberg, G., Pericak-Vance, M. A., Cuccaro, M., Scott, W. K., … Beecham, G. W. (2022). Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. -
TRACKING INNATE IMMUNE ACTIVATION IN A MOUSE MODEL OF PARKINSON'S DISEASE USING TREM1 AND TSPO PET TRACERS.
Lucot, K. L., Stevens, M. Y., Bonham, T. A., Azevedo, E. C., Chaney, A. M., Webber, E. D., … James, M. L. (2022). TRACKING INNATE IMMUNE ACTIVATION IN A MOUSE MODEL OF PARKINSON'S DISEASE USING TREM1 AND TSPO PET TRACERS. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. -
Hemispheric Asymmetry and Atypical Lobar Progression of Alzheimer-Type Tauopathy.
Tremblay, C., Serrano, G. E., Intorcia, A. J., Curry, J., Sue, L. I., Nelson, C. M., … Beach, T. G. (2022). Hemispheric Asymmetry and Atypical Lobar Progression of Alzheimer-Type Tauopathy. Journal of Neuropathology and Experimental Neurology. -
Putting Humpty Dumpty Back Together Again: What Does Protein Quantification Mean in Bottom-Up Proteomics?
Plubell, D. L., Kall, L., Webb-Robertson, B.-J., Bramer, L. M., Ives, A., Kelleher, N. L., … MacCoss, M. J. (2022). Putting Humpty Dumpty Back Together Again: What Does Protein Quantification Mean in Bottom-Up Proteomics? Journal of Proteome Research. -
Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid.
Hwangbo, N., Zhang, X., Raftery, D., Gu, H., Hu, S.-C., Montine, T. J., … Franks, A. (2022). Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid. Metabolites, 12(4). -
AI-enabled in silico immunohistochemical characterization for Alzheimer's disease.
He, B., Bukhari, S., Fox, E., Abid, A., Shen, J., Kawas, C., … Zou, J. (2022). AI-enabled in silico immunohistochemical characterization for Alzheimer's disease. Cell Reports Methods, 2(4), 100191. -
Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study.
Melikyan, Z. A., Corrada, M. M., Leiby, A.-M., Sajjadi, S. A., Bukhari, S., Montine, T. J., & Kawas, C. H. (2022). Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study. Neurobiology of Aging, 116, 12–15. -
Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.
Fernandez, B., Chittoor-Vinod, V. G., Kluss, J. H., Kelly, K., Bryant, N., Nguyen, A. P., … Hilfiker, S. (2022). Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity. Journal of Parkinson's Disease. -
Dysregulation of Brain inflammation in COVID-19: An autopsy series
Piras, I., Huentelman, M., Walker, J., Arce, R., Tremblay, C., Glass, M., … Beach, T. (2022). Dysregulation of Brain inflammation in COVID-19: An autopsy series. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
Acute Infarction, Hemorrhage and White Matter Beta-Amyloid Precursor Protein Immunostaining in COVID-19 and Control Subjects
DeTure, M., Walker, J., Arce, R., Glass, M., Sue, L., Intorcia, A., … Dickson, D. (2022). Acute Infarction, Hemorrhage and White Matter Beta-Amyloid Precursor Protein Immunostaining in COVID-19 and Control Subjects. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.
Nelson, P. T., Brayne, C., Flanagan, M. E., Abner, E. L., Agrawal, S., Attems, J., … Schneider, J. A. (2022). Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. Acta Neuropathologica. -
Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors.
Lesniak, R. K., Nichols, R. J., Schonemann, M., Zhao, J., Gajera, C. R., Lam, G., … Montine, T. J. (2022). Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors. ACS Medicinal Chemistry Letters, 13(6), 981–988. -
Association of Cognition and Dementia With Neuropathologic Changes of Alzheimer Disease and Other Conditions in the Oldest-Old.
Montine, T. J., Corrada, M. M., Kawas, C., Bukhari, S., White, L., Tian, L., & Cholerton, B. (2022). Association of Cognition and Dementia With Neuropathologic Changes of Alzheimer Disease and Other Conditions in the Oldest-Old. Neurology. -
Targeting LRRK2 mutations in Parkinson's disease.
Lesniak, R. K., Nichols, R. J., Smith, M., & Montine, T. J. (2022). Targeting LRRK2 mutations in Parkinson's disease. Future Medicinal Chemistry. -
Cognition as a mediator for gait and balance impairments in GBA-related Parkinson's disease.
Morris, R., Martini, D. N., Ramsey, K., Kelly, V. E., Smulders, K., Hiller, A., … Horak, F. (2022). Cognition as a mediator for gait and balance impairments in GBA-related Parkinson's disease. NPJ Parkinson's Disease, 8(1), 78. -
Rapid Deployment of Whole Slide Imaging for Primary Diagnosis in Surgical Pathology at Stanford Medicine.
Rojansky, R., Jhun, I., Dussaq, A. M., Chirieleison, S. M., Nirschl, J. J., Born, D., … Folkins, A. (2022). Rapid Deployment of Whole Slide Imaging for Primary Diagnosis in Surgical Pathology at Stanford Medicine. Archives of Pathology & Laboratory Medicine. -
Testing Gender and Longitudinal Measurement Invariance of the SF-36 in American Indian Older Adults: The Strong Heart Study
Barbosa-Leiker, C., Burduli, E., Arias-Losado, R., Muller, C., Noonan, C., Suchy-Dicey, A., … Buchwald, D. (2022). Testing Gender and Longitudinal Measurement Invariance of the SF-36 in American Indian Older Adults: The Strong Heart Study. PSYCHOLOGICAL ASSESSMENT. -
Parkinson's Progression Markers Initiative brain autopsy program.
Bukhari, S. A., Nudelman, K. N., Rumbaugh, M., Richeson, P., Fox, E. J., Montine, K. S., … Montine, T. J. (2022). Parkinson's Progression Markers Initiative brain autopsy program. Parkinsonism & Related Disorders, 101, 62–65. -
SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19.
Serrano, G. E., Walker, J. E., Tremblay, C., Piras, I. S., Huentelman, M. J., Belden, C. M., … Beach, T. G. (2022). SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19. Journal of Neuropathology and Experimental Neurology. -
Semi-quantitative Assessment of Alzheimer's-like Pathology in Two Aged Polar Bears (Ursus maritimus).
Lucot, K. L., Bukhari, S. A., Webber, E. D., Bonham, T. A., Darian-Smith, C., Montine, T. J., & Green, S. L. (2022). Semi-quantitative Assessment of Alzheimer's-like Pathology in Two Aged Polar Bears (Ursus maritimus). Comparative Medicine. -
Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors.
Lesniak, R. K., Nichols, R. J., Schonemann, M., Zhao, J., Gajera, C. R., Lam, G., … Montine, T. J. (2022). Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors. European Journal of Medicinal Chemistry, 242, 114693. -
Clonal Hematopoiesis is Associated with Reduced Risk of Alzheimer's Disease
Bouzid, H., Belk, J., Jan, M., Qi, Y., Sarnowski, C., Wirth, S., … Jaiswal, S. (2021). Clonal Hematopoiesis is Associated with Reduced Risk of Alzheimer's Disease. BLOOD. AMER SOC HEMATOLOGY. -
Impact and Risk Factors of Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Change in an Oldest Old Cohort.
Sajjadi, S. A., Bukhari, S., Scambray, K., Yan, R., Kawas, C., Montine, T. J., & Corrada, M. M. (2022). Impact and Risk Factors of Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Change in an Oldest Old Cohort. Neurology. -
Single-cell spatial proteomic imaging for human neuropathology.
Vijayaragavan, K., Cannon, B. J., Tebaykin, D., Bosse, M., Baranski, A., Oliveria, J. P., … Bendall, S. C. (2022). Single-cell spatial proteomic imaging for human neuropathology. Acta Neuropathologica Communications, 10(1), 158. -
Plasma Exchange in Alzheimer's Disease.
Rohrer, L., Yunce, M., Montine, T. J., & Shan, H. (2022). Plasma Exchange in Alzheimer's Disease. Transfusion Medicine Reviews. -
Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease.
Wilson, E. N., Young, C. B., Ramos Benitez, J., Swarovski, M. S., Feinstein, I., Vandijck, M., … Andreasson, K. I. (2022). Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease. Alzheimer's Research & Therapy, 14(1), 172. -
Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk
Lesniak, R. K., Nichols, R. J., & Montine, T. J. (2022). Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk. FRONTIERS IN NEUROLOGY, 13, 1016040. -
Methylation differences in Alzheimer's disease neuropathologic change in the aged human brain.
Lang, A.-L. L., Eulalio, T., Fox, E., Yakabi, K., Bukhari, S. A., Kawas, C. H., … Montine, T. J. (2022). Methylation differences in Alzheimer's disease neuropathologic change in the aged human brain. Acta Neuropathologica Communications, 10(1), 174. -
Illusory responses across the Lewy body disease spectrum
Shahid, M., Rawls, A., Ramirez, V., Ryman, S., Santini, V., Yang, L., … Poston, K. (2022). Illusory responses across the Lewy body disease spectrum. MOVEMENT DISORDERS. WILEY. -
LATE-NC staging in routine neuropathologic diagnosis: an update.
Nelson, P. T., Lee, E. B., Cykowski, M. D., Alafuzoff, I., Arfanakis, K., Attems, J., … Neumann, M. (2022). LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathologica. -
LATE and potential estrogen-related risk factors collected 30 years earlier:The 90+ Study.
Paganini-Hill, A., Montine, T. J., Bukhari, S. A., Corrada, M. M., Kawas, C. H., & Sajjadi, S. A. (2022). LATE and potential estrogen-related risk factors collected 30 years earlier:The 90+ Study. Journal of Neuropathology and Experimental Neurology. -
Prediction of neuropathologic lesions from clinical data.
Phongpreecha, T., Cholerton, B., Bhukari, S., Chang, A. L., De Francesco, D., Thuraiappah, M., … Montine, T. J. (2023). Prediction of neuropathologic lesions from clinical data. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. -
One Hundred Centenarians: Brain Pathology and Relationship to Dementia in The 90+Study (P1-1.Virtual)
Neuville, R., Ho, C.-C., Sajjadi, S. A., Biswas, R., Montine, T., Corrada, M., & Kawas, C. (2022). One Hundred Centenarians: Brain Pathology and Relationship to Dementia in The 90+Study (P1-1.Virtual). NEUROLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study.
Neuville, R. S., Biswas, R., Ho, C.-C. C., Bukhari, S., Sajjadi, S. A., Paganini-Hill, A., … Kawas, C. H. (2023). Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. -
Illusory Responses across the Lewy Body Disease Spectrum
Shahid, M., Rawls, A., Ramirez, V., Ryman, S., Santini, V. E., Yang, L., … Poston, K. L. (2023). Illusory Responses across the Lewy Body Disease Spectrum. ANNALS OF NEUROLOGY. -
AGING, COGNITIVE, AND PHYSICAL DECLINE IN VERVETS ( CHLOROCEBUS AETHIOPS SABAEUS)
Shively, C. A., Frye, B. M., Craft, S. M., Latimer, C., Keene, C. D., Montine, T. J., … Valure, P. (2023). AGING, COGNITIVE, AND PHYSICAL DECLINE IN VERVETS ( CHLOROCEBUS AETHIOPS SABAEUS). AMERICAN JOURNAL OF PRIMATOLOGY. WILEY. -
Superior Global Cognition in Oldest-Old Is Associated with Resistance to Neurodegenerative Pathologies: Results from The 90+ Study.
Biswas, R., Kawas, C., Montine, T. J., Bukhari, S. A., Jiang, L., & Corrada, M. M. (2023). Superior Global Cognition in Oldest-Old Is Associated with Resistance to Neurodegenerative Pathologies: Results from The 90+ Study. Journal of Alzheimer's Disease : JAD. -
A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease.
Merrihew, G. E., Park, J., Plubell, D., Searle, B. C., Keene, C. D., Larson, E. B., … MacCoss, M. J. (2023). A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease. Scientific Data, 10(1), 206. -
Rapid Deployment of Whole Slide Imaging for Primary Diagnosis in Surgical Pathology at Stanford Medicine Responding to Challenges of the COVID-19 Pandemic
Rojansky, R., Jhun, I., Dussaq, A. M., Chirieleison, S. M., Nirschl, J. J., Born, D., … Folkins, A. (2023). Rapid Deployment of Whole Slide Imaging for Primary Diagnosis in Surgical Pathology at Stanford Medicine Responding to Challenges of the COVID-19 Pandemic. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 147(3), 359–367. -
Predicting lymph node metastasis from primary tumor histology and clinicopathologic factors in colorectal cancer using deep learning.
Krogue, J. D., Azizi, S., Tan, F., Flament-Auvigne, I., Brown, T., Plass, M., … Wulczyn, E. (2023). Predicting lymph node metastasis from primary tumor histology and clinicopathologic factors in colorectal cancer using deep learning. Communications Medicine, 3(1), 59. -
Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease.
Huang, Z., Merrihew, G. E., Larson, E. B., Park, J., Plubell, D., Fox, E. J., … Montine, T. J. (2023). Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease. Nature Communications, 14(1), 2747. -
Gait and balance in apolipoprotein ?4 allele carriers in older adults and Parkinson's disease.
Morris, R., Martini, D. N., Kelly, V. E., Smulders, K., Ramsey, K., Hiller, A., … Horak, F. (2023). Gait and balance in apolipoprotein ?4 allele carriers in older adults and Parkinson's disease. Clinical Parkinsonism & Related Disorders, 9, 100201. -
Metrologically Traceable Quantification of 3 Apolipoprotein E Isoforms in Cerebrospinal Fluid.
Huynh, H.-H., Kuch, K., Orquillas, A., Forrest, K., Barahona-Carrillo, L., Keene, D., … Hoofnagle, A. N. (2023). Metrologically Traceable Quantification of 3 Apolipoprotein E Isoforms in Cerebrospinal Fluid. Clinical Chemistry. -
Clonal hematopoiesis is associated with protection from Alzheimer's disease.
Bouzid, H., Belk, J. A., Jan, M., Qi, Y., Sarnowski, C., Wirth, S., … Jaiswal, S. (2023). Clonal hematopoiesis is associated with protection from Alzheimer's disease. Nature Medicine. -
Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old.
Sordo, L., Qian, T., Bukhari, S. A., Nguyen, K. M., Woodworth, D. C., Head, E., … Sajjadi, S. A. (2023). Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old. Acta Neuropathologica. -
Alzheimer's Disease Neuropathologic Change and Vitamin Supplement Use Decades Earlier The 90+Study
Paganini-Hill, A., Bukhari, S., Montine, T. J. J., Corrada, M. M. M., & Kawas, C. H. H. (2023). Alzheimer's Disease Neuropathologic Change and Vitamin Supplement Use Decades Earlier The 90+Study. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 37(1), 1–6. -
Neuropathologic Changes of Alzheimer's Disease and Related Dementias: Relevance to Future Prevention.
White, L. R., Corrada, M. M., Kawas, C. H., Cholerton, B. A., Edland, S. E., Flanagan, M. E., & Montine, T. J. (2023). Neuropathologic Changes of Alzheimer's Disease and Related Dementias: Relevance to Future Prevention. Journal of Alzheimer's Disease : JAD. -
Neuroinflammation and Oxidative Injury in Developmental Neurotoxicity
Milatovic, D., Zaja-Milatovic, S., Breyer, R. M., Aschner, M., & Montine, T. J. (2017). Neuroinflammation and Oxidative Injury in Developmental Neurotoxicity. REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY, 2ND EDITION, 1051–1061. -
"Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia"
Jagust, W., Jack, C. R., Bennett, D. A., Blennow, K., Haeberlein, S. B., Holtzman, D. M., … Sperling, R. (2019). "Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia". ALZHEIMERS & DEMENTIA, 15(1), 153–157. -
A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis
Latimer, C. S., Shively, C. A., Keene, C. D., Jorgensen, M. J., Andrews, R. N., Register, T. C., … Craft, S. (2019). A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis. ALZHEIMERS & DEMENTIA, 15(1), 93–105. -
Application of a condensed NIA-AA protocol for the pathologic assessment of Alzheimer's disease in an academic hospital autopsy service
Bharadwaj, R., Cimino, P., Flanagan, M., Latimer, C., Gonzalez-Cuyar, L., Juric-Sekhar, G., … Keene, C. (2017). Application of a condensed NIA-AA protocol for the pathologic assessment of Alzheimer's disease in an academic hospital autopsy service. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature.
Berson, E., Sreenivas, A., Phongpreecha, T., Perna, A., Grandi, F. C., Xue, L., … Montine, T. J. (2023). Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature. Nature Communications, 14(1), 4947. -
A visual-language foundation model for pathology image analysis using medical Twitter.
Huang, Z., Bianchi, F., Yuksekgonul, M., Montine, T. J., & Zou, J. (2023). A visual-language foundation model for pathology image analysis using medical Twitter. Nature Medicine. -
Cross-species comparative analysis of single presynapses.
Berson, E., Gajera, C. R., Phongpreecha, T., Perna, A., Bukhari, S. A., Becker, M., … Montine, T. J. (2023). Cross-species comparative analysis of single presynapses. Scientific Reports, 13(1), 13849. -
Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia.
Perna, A., Montine, K. S., White, L. R., Montine, T. J., & Cholerton, B. A. (2023). Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. -
Characterizing Limbic-Predominant Age-Related TDP-43 Encephalopathy Without Alzheimer's Disease and Lewy Body Dementia in the Oldest Old: A Case Series.
Leiby, A.-M. C., Scambray, K. A., Nguyen, H. L., Basith, F., Fakhraee, S., Melikyan, Z. A., … Sajjadi, S. A. (2023). Characterizing Limbic-Predominant Age-Related TDP-43 Encephalopathy Without Alzheimer's Disease and Lewy Body Dementia in the Oldest Old: A Case Series. Journal of Alzheimer's Disease : JAD. -
Unveiling Resilience to Alzheimer's Disease: Insights From Brain Regional Proteomic Markers.
Huang, Z., Merrihew, G. E., Larson, E. B., Park, J., Plubell, D., Fox, E. J., … Montine, T. J. (2023). Unveiling Resilience to Alzheimer's Disease: Insights From Brain Regional Proteomic Markers. Neuroscience Insights, 18, 26331055231201600. -
Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease.
Serrano, G. E., Walker, J. E., Arce, R., Glass, M. J., Vargas, D., Sue, L. I., … Beach, T. G. (2021). Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease. MedRxiv : the Preprint Server for Health Sciences. -
Spatial proteomics reveals human microglial states shaped by anatomy and neuropathology.
Mrdjen, D., Amouzgar, M., Cannon, B., Liu, C., Spence, A., McCaffrey, E., … Bendall, S. C. (2023). Spatial proteomics reveals human microglial states shaped by anatomy and neuropathology. Research Square. -
Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia
Perna, A., Montine, K. S., White, L. R., Montine, T. J., & Cholerton, B. A. (2023). Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia. NEUROTHERAPEUTICS. -
Quantitative estimate of cognitive resilience and its medical and genetic associations.
Phongpreecha, T., Godrich, D., Berson, E., Espinosa, C., Kim, Y., Cholerton, B., … Montine, T. J. (2023). Quantitative estimate of cognitive resilience and its medical and genetic associations. Alzheimer's Research & Therapy, 15(1), 192. -
Neuropathologic Burden and Dementia in Nonagenarians and Centenarians.
Cholerton, B., Latimer, C. S., Crane, P. K., Corrada, M. M., Gibbons, L. E., Larson, E. B., … Montine, T. J. (2024). Neuropathologic Burden and Dementia in Nonagenarians and Centenarians. Neurology, 102(3), e208060. -
Understanding the molecular basis of resilience to Alzheimer's disease
Montine, K. S., Berson, E., Phongpreecha, T., Huang, Z., Aghaeepour, N., Zou, J. Y., … Montine, T. J. (2023). Understanding the molecular basis of resilience to Alzheimer's disease. FRONTIERS IN NEUROSCIENCE, 17. -
Understanding the molecular basis of resilience to Alzheimer's disease.
Montine, K. S., Berson, E., Phongpreecha, T., Huang, Z., Aghaeepour, N., Zou, J. Y., … Montine, T. J. (2023). Understanding the molecular basis of resilience to Alzheimer's disease. Frontiers in Neuroscience, 17, 1311157. -
A biological definition of neuronal a-synuclein disease: towards an integrated staging system for research.
Simuni, T., Chahine, L. M., Poston, K., Brumm, M., Buracchio, T., Campbell, M., … Marek, K. (2024). A biological definition of neuronal a-synuclein disease: towards an integrated staging system for research. The Lancet. Neurology, 23(2), 178–190. -
Lewy body dementia: Overcoming barriers and identifying solutions.
Agarwal, K., Backler, W., Bayram, E., Bloom, L., Boeve, B. F., Cha, J.-H. H., … Hyman, B. T. (2024). Lewy body dementia: Overcoming barriers and identifying solutions. Alzheimer's & Dementia : the Journal of the Alzheimer's Association.
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