Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Infectious Disease (2018)
- Medical Education: The Ohio State University College of Medicine (1992) OH
- Residency: University of Virginia Health System (1995) VA
- Fellowship: University of Virginia School of Medicine (1998) VA
- Internship: University of Virginia Health System (1993) VA
- BS, Ohio State University, Biochemistry (1987)
- MD, Ohio State University, Medicine (1992)
Honors & Awards
- Member, ASCI (2010)
Memberships
- Fellow, Center for Innovation in Global Health, Stanford University (2015 - Present)
Administrative Appointments
- Associate Chair, Faculty Development, Department of Medicine (2020 - Present)
- Division Chief, Infectious Diseases and Geographic Medicine (2010 - Present)
- Fellowship Co-Director, Division of Infectious Diseases (2008 - 2013)
Publications
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Context-dependent roles of the Entamoeba histolytica core promoter element GAAC in transcriptional activation and protein complex assembly
Singh, U., Gilchrist, C. A., Schaenman, J. M., Rogers, J. B., Hockensmith, J. W., Mann, B. J., & Petri, W. A. (2002). Context-dependent roles of the Entamoeba histolytica core promoter element GAAC in transcriptional activation and protein complex assembly. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 120(1), 107–116. -
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Toxoplasma gondii asexual development: Identification of developmentally regulated genes and distinct patterns of gene expression
Cleary, M. D., Singh, U., Blader, I. J., Brewer, J. L., & Boothroyd, J. C. (2002). Toxoplasma gondii asexual development: Identification of developmentally regulated genes and distinct patterns of gene expression. EUKARYOTIC CELL, 1(3), 329–40. -
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The genome of the protist parasite Entamoeba histolytica
Loftus, B., Anderson, I., Davies, R., Alsmark, U. C. M., Samuelson, J., Amedeo, P., … Hall, N. (2005). The genome of the protist parasite Entamoeba histolytica. NATURE, 433(7028), 865–68. -
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Transcriptional profiling of Entamoeba histolytica trophozoites
MacFarlane, R. C., Shah, P. H., & Singh, U. (2005). Transcriptional profiling of Entamoeba histolytica trophozoites. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 35(5), 533–42. -
Genomic DNA microarrays for Entamoeba histolytica: Applications for use in expression profiling and strain genotyping
Macfarlane, R., Bhattacharya, D., & Singh, U. (2005). Genomic DNA microarrays for Entamoeba histolytica: Applications for use in expression profiling and strain genotyping. EXPERIMENTAL PARASITOLOGY, 110(3), 196–202. -
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Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome
Gilchrist, C. A., Houpt, E., Trapaidze, N., Fei, Z., Crasta, O., Asgharpour, A., … Petri, W. A. (2006). Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 147(2), 163–76. -
Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression
Ali, I. K. M., Ehrenkaufer, G. M., Hackney, J. A., & Singh, U. (2007). Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression. BMC GENOMICS, 8. -
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Identification of putative transcriptional regulatory networks in Entamoeba histolytica using Bayesian inference
Hackney, J. A., Ehrenkaufer, G. M., & Singh, U. (2007). Identification of putative transcriptional regulatory networks in Entamoeba histolytica using Bayesian inference. NUCLEIC ACIDS RESEARCH, 35(7), 2141–52. -
Functional characterization of spliceosomal introns and identification of U2, U4, and U5 snRNAs in the deep-branching eukaryote Entamoeba histolytica
Davis, C. A., Brown, M. P. S., & Singh, U. (2007). Functional characterization of spliceosomal introns and identification of U2, U4, and U5 snRNAs in the deep-branching eukaryote Entamoeba histolytica. EUKARYOTIC CELL, 6(6), 940–48. -
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Structure and content of the Entamoeba histolytica genome
Clark, C. G., Alsmark, U. C. M., Tazreiter, M., Saito-Nakano, Y., Ali, V., Marion, S., … Hall, N. (2007). Structure and content of the Entamoeba histolytica genome. ADVANCES IN PARASITOLOGY, VOL 65, 65, 51–190. -
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New insights into Entamoeba histolytica pathogenesis
Baxt, L. A., & Singh, U. (2008). New insights into Entamoeba histolytica pathogenesis. CURRENT OPINION IN INFECTIOUS DISEASES, 21(5), 489–94. -
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Transcriptional Regulatory Networks in Entamoeba histolytica
Ehrenkaufer, G. M., & Singh, U. (2008). Transcriptional Regulatory Networks in Entamoeba histolytica. CURRENT DRUG TARGETS, 9(11), 931–37. -
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Downregulation of an Entamoeba histolytica Rhomboid Protease Reveals Roles in Regulating Parasite Adhesion and Phagocytosis
Baxt, L. A., Rastew, E., Bracha, R., Mirelman, D., & Singh, U. (2010). Downregulation of an Entamoeba histolytica Rhomboid Protease Reveals Roles in Regulating Parasite Adhesion and Phagocytosis. EUKARYOTIC CELL, 9(8), 1283–93. -
Approaches to characterizing Entamoeba histolytica transcriptional regulation
Pearson, R. J., & Singh, U. (2010). Approaches to characterizing Entamoeba histolytica transcriptional regulation. CELLULAR MICROBIOLOGY, 12(12), 1681–1690. -
RNA interference in Entamoeba histolytica: implications for parasite biology and gene silencing
Zhang, H., Pompey, J. M., & Singh, U. (2011). RNA interference in Entamoeba histolytica: implications for parasite biology and gene silencing. FUTURE MICROBIOLOGY, 6(1), 103–17. -
Antiparasitic Therapy
Kappagoda, S., Singh, U., & Blackburn, B. G. (2011). Antiparasitic Therapy. MAYO CLINIC PROCEEDINGS, 86(6), 561–83. -
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Transcription initiation is controlled by three core promoter elements in the hgl5 gene of the protozoan parasite Entamoeba histolytica
Singh, U., Rogers, J. B., Mann, B. J., & Petri, W. A. (1997). Transcription initiation is controlled by three core promoter elements in the hgl5 gene of the protozoan parasite Entamoeba histolytica. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(16), 8812–8817. -
The novel core promoter element GAAC in the hgl5 gene of Entamoeba histolytica is able to direct a transcription start site independent of TATA or Inr regions.
The novel core promoter element GAAC in the hgl5 gene of Entamoeba histolytica is able to direct a transcription start site independent of TATA or Inr regions. (1998). Journal of Biological Chemistry., (273). -
Diagnosis and management of amebiasis.
Diagnosis and management of amebiasis. (1999). Clinical Infectious Diseases., (29). -
Investigating amoebic pathogenesis using Entamoeba histolytica DNA microarrays
Singh, U., & Shah, P. (2002). Investigating amoebic pathogenesis using Entamoeba histolytica DNA microarrays. JOURNAL OF BIOSCIENCES, 27(6), 595–601. -
Short hairpin RNA-mediated knockdown of protein expression in Entamoeba histolytica
Linford, A. S., Moreno, H., Good, K. R., Zhang, H., Singh, U., & Petri, W. A. (2009). Short hairpin RNA-mediated knockdown of protein expression in Entamoeba histolytica. BMC MICROBIOLOGY, 9. -
Diagnosis and management of amebiasis
Petri, W. A., & Singh, U. (1999). Diagnosis and management of amebiasis. CLINICAL INFECTIOUS DISEASES, 29(5), 1117–1125. -
Small RNA pyrosequencing in the protozoan parasite Entamoeba histolytica reveals strain-specific small RNAs that target virulence genes
Zhang, H., Ehrenkaufer, G. M., Hall, N., & Singh, U. (2013). Small RNA pyrosequencing in the protozoan parasite Entamoeba histolytica reveals strain-specific small RNAs that target virulence genes. BMC GENOMICS, 14. -
Robust gene silencing mediated by antisense small RNAs in the pathogenic protist Entamoeba histolytica.
Morf, L., Pearson, R. J., Wang, A. S., & Singh, U. (2013). Robust gene silencing mediated by antisense small RNAs in the pathogenic protist Entamoeba histolytica. Nucleic Acids Research, 41(20), 9424–37. -
The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation.
Ehrenkaufer, G. M., Weedall, G. D., Williams, D., Lorenzi, H. A., Caler, E., Hall, N., & Singh, U. (2013). The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation. Genome Biology, 14(7), R77. -
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Destabilization domain approach adapted for regulated protein expression in the protozoan parasite Entamoeba histolytica.
Liu, Y.-C., & Singh, U. (2014). Destabilization domain approach adapted for regulated protein expression in the protozoan parasite Entamoeba histolytica. International Journal for Parasitology, 44(10), 729–35. -
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Three conserved cis-acting sequences in the core promoter control gene expression in the protozoan parasite Entamoeba histolytica.
Singh, U., Purdy, J., Mann, B. J., & Petri, W. A. (1997). Three conserved cis-acting sequences in the core promoter control gene expression in the protozoan parasite Entamoeba histolytica. Archives of Medical Research, 28, 41–42. -
The novel core promoter element GAAC in the hgl5 gene of Entamoeba histolytica is able to direct a transcription start site independent of TATA or initiator regions
Singh, U., & Rogers, J. B. (1998). The novel core promoter element GAAC in the hgl5 gene of Entamoeba histolytica is able to direct a transcription start site independent of TATA or initiator regions. JOURNAL OF BIOLOGICAL CHEMISTRY, 273(34), 21663–21668. -
High Throughput Sequencing of Entamoeba 27nt Small RNA Population Reveals Role in Permanent Gene Silencing But No Effect on Regulating Gene Expression Changes during Stage Conversion, Oxidative, or Heat Shock Stress.
Zhang, H., Ehrenkaufer, G. M., Manna, D., Hall, N., & Singh, U. (2015). High Throughput Sequencing of Entamoeba 27nt Small RNA Population Reveals Role in Permanent Gene Silencing But No Effect on Regulating Gene Expression Changes during Stage Conversion, Oxidative, or Heat Shock Stress. PloS One, 10(8). -
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RNAi pathway genes are resistant to small RNA mediated gene silencing in the protozoan parasite Entamoeba histolytica.
Pompey, J. M., Morf, L., & Singh, U. (2014). RNAi pathway genes are resistant to small RNA mediated gene silencing in the protozoan parasite Entamoeba histolytica. PloS One, 9(9). -
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Policy Recommendations for Optimizing the Infectious Diseases Physician-Scientist Workforce.
Singh, U., Levy, J., Armstrong, W., Bedimo, R., Creech, C. B., Lautenbach, E., … Vyas, J. M. (2018). Policy Recommendations for Optimizing the Infectious Diseases Physician-Scientist Workforce. The Journal of Infectious Diseases, 218(suppl_1), S49–S54. -
Supporting Research Career Development of Physician-Scientists
Singh, U. (2018). Supporting Research Career Development of Physician-Scientists. JOURNAL OF INFECTIOUS DISEASES, 218, S36–S39. -
High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites
Ehrenkaufer, G. M., Suresh, S., Solow-Cordero, D., & Singh, U. (2018). High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 8. -
Entamoeba histolytica Genomic Analyses
Singh, U., & Ehrenkaufer, G. M. (2010). Entamoeba histolytica Genomic Analyses. ANAEROBIC PARASITIC PROTOZOA: GENOMICS AND MOLECULAR BIOLOGY, 157–73. -
Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii
Matrajt, M., Donald, R. G., Singh, U., & Roos, D. S. (2002). Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii. MOLECULAR MICROBIOLOGY, 44(3), 735–47. -
High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites.
Ehrenkaufer, G. M., Suresh, S., Solow-Cordero, D., & Singh, U. (2018). High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites. Frontiers in Cellular and Infection Microbiology, 8, 276. -
An NAD+-dependent novel transcription factor controls stage conversion in Entamoeba.
Manna, D., Lentz, C. S., Ehrenkaufer, G. M., Suresh, S., Bhat, A., & Singh, U. (2018). An NAD+-dependent novel transcription factor controls stage conversion in Entamoeba. ELife, 7. -
Dimethylated H3K27 Is a Repressive Epigenetic Histone Mark in the Protist Entamoeba histolytica and Is Significantly Enriched in Genes Silenced via the RNAi Pathway.
Foda, B. M., & Singh, U. (2015). Dimethylated H3K27 Is a Repressive Epigenetic Histone Mark in the Protist Entamoeba histolytica and Is Significantly Enriched in Genes Silenced via the RNAi Pathway. The Journal of Biological Chemistry, 290(34), 21114–30. -
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Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.
Ehrenkaufer, G., Li, P., Stebbins, E. E., Kangussu-Marcolino, M. M., Debnath, A., White, C. V., … Singh, U. (2020). Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Neglected Tropical Diseases, 14(3), e0008150. -
Drug treatment algorithms for water-borne parasitic pathogens
Singh, U. (2019). Drug treatment algorithms for water-borne parasitic pathogens. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 258. -
Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity
Ehrenkaufer, G., Li, P., Stebbins, E. E., Kangussu-Marcolino, M. M., Debnath, A., White, C., … Singh, U. (2020). Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLOS NEGLECTED TROPICAL DISEASES, 14(3). -
Characterization of extracellular vesicles from Entamoeba histolytica identifies roles in intercellular communication that regulates parasite growth and development.
Sharma, M., Morgado, P., Zhang, H., Ehrenkaufer, G., Manna, D., & Singh, U. (2020). Characterization of extracellular vesicles from Entamoeba histolytica identifies roles in intercellular communication that regulates parasite growth and development. Infection and Immunity. -
The NAD+ Responsive Transcription Factor ERM-BP Functions Downstream of Cellular Aggregation and Is an Early Regulator of Development and Heat Shock Response in Entamoeba.
Manna, D., Lozano-Amado, D., Ehrenkaufer, G., & Singh, U. (2020). The NAD+ Responsive Transcription Factor ERM-BP Functions Downstream of Cellular Aggregation and Is an Early Regulator of Development and Heat Shock Response in Entamoeba. Frontiers in Cellular and Infection Microbiology, 10, 363. -
Entamoeba stage conversion: progress and new insights.
Manna, D., Ehrenkaufer, G. M., Lozano-Amado, D., & Singh, U. (2020). Entamoeba stage conversion: progress and new insights. Current Opinion in Microbiology, 58, 62–68. -
Interferon-gamma release assay for accurate detection of SARS-CoV-2 T cell response.
Murugesan, K., Jagannathan, P., Pham, T. D., Pandey, S., Bonilla, H. F., Jacobson, K., … Banaei, N. (2020). Interferon-gamma release assay for accurate detection of SARS-CoV-2 T cell response. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Proinflammatory IgG Fc structures in patients with severe COVID-19
Chakraborty, S., Gonzales, J., Edwards, K., Mallajosyulla, V., Buzzanco, A. S., Sherwood, R., … Tan, G. S. (2020). Proinflammatory IgG Fc structures in patients with severe COVID-19. Nature Immunology. -
Development of a CRISPR/Cas9 system in Entamoeba histolytica: proof of concept.
Kangussu-Marcolino, M. M., Morgado, P., Manna, D., Yee, H., & Singh, U. (2020). Development of a CRISPR/Cas9 system in Entamoeba histolytica: proof of concept. International Journal for Parasitology. -
Identification of oligo-adenylated small RNAs in the parasite Entamoeba and a potential role for small RNA control.
Zhang, H., Ehrenkaufer, G. M., Hall, N., & Singh, U. (2020). Identification of oligo-adenylated small RNAs in the parasite Entamoeba and a potential role for small RNA control. BMC Genomics, 21(1), 879. -
Patients with uncomplicated COVID-19 have long-term persistent symptoms and functional impairment similar to patients with severe COVID-19: a cautionary tale during a global pandemic.
Jacobson, K. B., Rao, M., Bonilla, H., Subramanian, A., Hack, I., Madrigal, M., … Grant, P. (2021). Patients with uncomplicated COVID-19 have long-term persistent symptoms and functional impairment similar to patients with severe COVID-19: a cautionary tale during a global pandemic. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial.
Jagannathan, P., Andrews, J. R., Bonilla, H., Hedlin, H., Jacobson, K. B., Balasubramanian, V., … Singh, U. (2021). Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial. Nature Communications, 12(1), 1967. -
SARS-CoV-2 subgenomic RNA kinetics in longitudinal clinical samples
Verma, R., Kim, E., Martinez, G., Jagannathan, P., Rustagi, A., Parsonnet, J., … Andrews, J. (2021). SARS-CoV-2 subgenomic RNA kinetics in longitudinal clinical samples. Open Forum Infectious Diseases. -
The COVID-19 Outpatient Pragmatic Platform Study (COPPS): Study design of a multi-center pragmatic platform trial.
Bunning, B., Hedlin, H., Purington, N., Sundaram, V., Kapphahn, K., Weng, Y., … Desai, M. (2021). The COVID-19 Outpatient Pragmatic Platform Study (COPPS): Study design of a multi-center pragmatic platform trial. Contemporary Clinical Trials, 106509. -
RISC in Entamoeba histolytica: Identification of a Protein-Protein Interaction Network for the RNA Interference Pathway in a Deep-Branching Eukaryote.
Zhang, H., Veira, J., Bauer, S. T., Yip, C., & Singh, U. (2021). RISC in Entamoeba histolytica: Identification of a Protein-Protein Interaction Network for the RNA Interference Pathway in a Deep-Branching Eukaryote. MBio, e0154021. -
New-onset IgG autoantibodies in hospitalized patients with COVID-19.
Chang, S. E., Feng, A., Meng, W., Apostolidis, S. A., Mack, E., Artandi, M., … Utz, P. J. (2021). New-onset IgG autoantibodies in hospitalized patients with COVID-19. Nature Communications, 12(1), 5417. -
Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA.
Natarajan, A., Han, A., Zlitni, S., Brooks, E. F., Vance, S. E., Wolfe, M., … Bhatt, A. S. (2021). Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. Nature Communications, 12(1), 5753. -
Standardized and optimized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA.
Natarajan, A., Han, A., Zlitni, S., Brooks, E. F., Vance, S. E., Wolfe, M., … Bhatt, A. S. (2021). Standardized and optimized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. MedRxiv : the Preprint Server for Health Sciences. -
Publisher Correction: Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA.
Natarajan, A., Han, A., Zlitni, S., Brooks, E. F., Vance, S. E., Wolfe, M., … Bhatt, A. S. (2021). Publisher Correction: Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. Nature Communications, 12(1), 7100. -
Ponatinib, Lestaurtinib and mTOR/PI3K inhibitors are promising repurposing candidates against Entamoeba histolytica.
Kangussu-Marcolino, M. M., & Singh, U. (2021). Ponatinib, Lestaurtinib and mTOR/PI3K inhibitors are promising repurposing candidates against Entamoeba histolytica. Antimicrobial Agents and Chemotherapy, AAC0120721. -
Inflammatory but not respiratory symptoms are associated with ongoing upper airway viral shedding in outpatients with uncomplicated COVID-19.
Jacobson, K. B., Purington, N., Parsonnet, J., Andrews, J., Balasubramanian, V., Bonilla, H., … Jagannathan, P. (2021). Inflammatory but not respiratory symptoms are associated with ongoing upper airway viral shedding in outpatients with uncomplicated COVID-19. Diagnostic Microbiology and Infectious Disease, 102(3), 115612. -
Variation in Severe Acute Respiratory Syndrome Coronavirus 2 Bioaerosol Production in Exhaled Breath.
Verma, R., Kim, E., Degner, N., Walter, K. S., Singh, U., & Andrews, J. R. (2022). Variation in Severe Acute Respiratory Syndrome Coronavirus 2 Bioaerosol Production in Exhaled Breath. Open Forum Infectious Diseases, 9(1), ofab600. -
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses.
Sievers, B. L., Chakraborty, S., Xue, Y., Gelbart, T., Gonzalez, J. C., Cassidy, A. G., … Tan, G. S. (1800). Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses. Science Translational Medicine, eabn7842. -
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity.
Chakraborty, S., Gonzalez, J. C., Sievers, B. L., Mallajosyula, V., Chakraborty, S., Dubey, M., … Wang, T. T. (1800). Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity. Science Translational Medicine, eabm7853. -
Long Term Accuracy of SARS-CoV-2 Interferon-? Release Assay and its Application in Household Investigation.
Murugesan, K., Jagannathan, P., Altamirano, J., Maldonado, Y. A., Bonilla, H. F., Jacobson, K. B., … Banaei, N. (2022). Long Term Accuracy of SARS-CoV-2 Interferon-? Release Assay and its Application in Household Investigation. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19.
Hu, Z., van der Ploeg, K., Chakraborty, S., Arunachalam, P., Mori, D., Jacobson, K., … Jagannathan, P. (2022). Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19. Research Square. -
New-Onset IgG Autoantibodies in Hospitalized Patients with COVID-19
Chang, S., Feng, A., Meng, W., Apostolidis, S., Mack, E., Artandi, M., … Utz, P. (2021). New-Onset IgG Autoantibodies in Hospitalized Patients with COVID-19. ARTHRITIS & RHEUMATOLOGY. WILEY. -
SARS-CoV-2 Neutralizing Monoclonal Antibodies for the Treatment of COVID-19 in Kidney Transplant Recipients.
Wang, A. X., Busque, S., Kuo, J., Singh, U., Roeltgen, K., Pinsky, B. A., … Lenihan, C. R. (2022). SARS-CoV-2 Neutralizing Monoclonal Antibodies for the Treatment of COVID-19 in Kidney Transplant Recipients. Kidney360, 3(1), 133–143. -
Favipiravir for treatment of outpatients with asymptomatic or uncomplicated COVID-19: a double-blind randomized, placebo-controlled, phase 2 trial.
Holubar, M., Subramanian, A., Purington, N., Hedlin, H., Bunning, B., Walter, K. S., … Maldonado, Y. (2022). Favipiravir for treatment of outpatients with asymptomatic or uncomplicated COVID-19: a double-blind randomized, placebo-controlled, phase 2 trial. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. -
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection.
Natarajan, A., Zlitni, S., Brooks, E. F., Vance, S. E., Dahlen, A., Hedlin, H., … Bhatt, A. S. (2022). Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection. Med (New York, N.Y.). -
TNF-alpha+ CD4+ Tcells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies.
van der Ploeg, K., Kirosingh, A. S., Mori, D. A., Chakraborty, S., Hu, Z., Sievers, B. L., … Jagannathan, P. (2022). TNF-alpha+ CD4+ Tcells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies. Cell Reports. Medicine, 100640. -
Successful recruitment of monolingual Spanish speaking Latinos to university phase II and III outpatient COVID-19 clinical treatment trials in Northern California.
Levy, V., Bengoa, R. Y., Romero, P. P., Bollyky, J., & Singh, U. (2022). Successful recruitment of monolingual Spanish speaking Latinos to university phase II and III outpatient COVID-19 clinical treatment trials in Northern California. Contemporary Clinical Trials, 106891. -
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study.
Hu, Z., van der Ploeg, K., Chakraborty, S., Arunachalam, P. S., Mori, D. A., Jacobson, K. B., … Jagannathan, P. (2022). Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study. ELife, 11. -
Turning the page: a welcome from the new leadership of the Journal of Infectious Diseases.
Sears, C. L., Li, J. Z., & Singh, U. (2022). Turning the page: a welcome from the new leadership of the Journal of Infectious Diseases. The Journal of Infectious Diseases, 227(1), 1–3. -
Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
McCarthy, M. W., Naggie, S., Boulware, D. R., Lindsell, C. J., Stewart, T. G., Felker, G. M., … Hernandez, A. F. (2023). Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial. JAMA. -
Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference.
Walter, K. S., Kim, E., Verma, R., Altamirano, J., Leary, S., Carrington, Y. J., … Andrews, J. R. (2023). Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference. Open Forum Infectious Diseases, 10(2), ofad001. -
Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness.
Feng, A., Yang, E. Y., Moore, A. R., Dhingra, S., Chang, S. E., Yin, X., … Utz, P. J. (2023). Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness. JCI Insight, 8(3). -
Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves.
Sharma, M., Zhang, H., Ehrenkaufer, G., & Singh, U. (2023). Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves. MBio, e0345022. -
Transparent Reporting at the Journal of Infectious Diseases.
Clancy, C. J., Li, J. Z., Singh, U., & Sears, C. L. (2023). Transparent Reporting at the Journal of Infectious Diseases. The Journal of Infectious Diseases. -
Diversity and Plasticity of Virulent Characteristics of Entamoeba histolytica.
Yanagawa, Y., & Singh, U. (2023). Diversity and Plasticity of Virulent Characteristics of Entamoeba histolytica. Tropical Medicine and Infectious Disease, 8(5). -
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection.
Thaweethai, T., Jolley, S. E., Karlson, E. W., Levitan, E. B., Levy, B., McComsey, G. A., … Zisis, S. (2023). Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. JAMA. -
Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.
Horwitz, L. I., Thaweethai, T., Brosnahan, S. B., Cicek, M. S., Fitzgerald, M. L., Goldman, J. D., … Foulkes, A. S. (2023). Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PloS One, 18(6), e0286297. -
The Tomato Brown Rugose Fruit Virus Movement Protein Gene Is a Novel Microbial Source Tracking Marker.
Natarajan, A., Fremin, B. J., Schmidtke, D. T., Wolfe, M. K., Zlitni, S., Graham, K. E., … Boehm, A. B. (2023). The Tomato Brown Rugose Fruit Virus Movement Protein Gene Is a Novel Microbial Source Tracking Marker. Applied and Environmental Microbiology, e0058323. -
Extracellular Vesicles and Their Impact on the Biology of Protozoan Parasites.
Sharma, M., Lozano-Amado, D., Chowdhury, D., & Singh, U. (2023). Extracellular Vesicles and Their Impact on the Biology of Protozoan Parasites. Tropical Medicine and Infectious Disease, 8(9). -
Safety and efficacy of inhaled interferon-ß1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial.
Jagannathan, P., Chew, K. W., Giganti, M. J., Hughes, M. D., Moser, C., Main, M. J., … Fischer, W. (2023). Safety and efficacy of inhaled interferon-ß1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial. EClinicalMedicine, 65, 102250. -
Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections.
Feng, A., Yang, E., Moore, A., Dhingra, S., Chang, S., Yin, X., … Utz, P. (2022). Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections. Research Square. -
Higher-Dose Fluvoxamine and Time to Sustained Recovery in Outpatients With COVID-19: The ACTIV-6 Randomized Clinical Trial.
Stewart, T. G., Rebolledo, P. A., Mourad, A., Lindsell, C. J., Boulware, D. R., McCarthy, M. W., … Naggie, S. (2023). Higher-Dose Fluvoxamine and Time to Sustained Recovery in Outpatients With COVID-19: The ACTIV-6 Randomized Clinical Trial. JAMA. -
2023: Looking Back and Looking Ahead
Li, J. Z., Clancy, C. J., Singh, U., & Sears, C. L. (2024). 2023: Looking Back and Looking Ahead. JOURNAL OF INFECTIOUS DISEASES, 619–620. -
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection (vol 329, pg 1934, 2023)
Thaweethai, T., Jolley, S. E., Karlson, E. W., Levitan, E. B., Levy, B., McComsey, G. A., … Foulkes, A. S. (2024). Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection (vol 329, pg 1934, 2023). JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- ACTIV-6: COVID-19 Study of Repurposed Medications »
- Understanding the Long-term Impact of COVID-19 in Adults (RECOVER) »
- ACTIV-2: A Study for Outpatients With COVID-19 »
- Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult and Pediatric Patients With COVID-19 »
- Oral Favipiravir Compared to Placebo in Subjects With Mild COVID-19 »
- Oral Camostat Compared With Standard Supportive Care in Mild-Moderate COVID-19 Patients »
- Single-Blind Study of a Single Dose of Peginterferon Lambda-1a Compared With Placebo in Outpatients With Mild COVID-19 »
- COVID-19 Outpatient Pragmatic Platform Study (COPPS) - Master Protocol »
- Paxlovid for Treatment of Long Covid »
Practice Locations
Infectious Disease Clinic in Palo Alto Palo Alto, CA
Palo Alto, CAInfectious Disease Clinic in Palo Alto
211 Quarry Road, 2nd Floor, Suite 202
Palo Alto , CA 94304
Make An Appointment More Clinic Information » Getting Here »Referring Physicians
PHYSICIAN HELPLINE
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Stanford Health Care provides comprehensive services to refer and track patients, as well as the latest information and news for physicians and office staff. For help with all referral needs and questions, visit Referral Information.
You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
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