Biography
Professional Summary
Education & Certifications
- Board Certification: National Board of Echocardiography, Adult Echocardiography (2008)
- Board Certification: American Board of Internal Medicine, Cardiovascular Disease (2022)
- Fellowship: Stanford University Cardiovascular Medicine Fellowship (1998) CA
- Residency: UCLA Medical Center Internal Medicine (1993) CA
- Medical Education: Yale School Of Medicine (1989) CT
- Resident, UCLA Department of Medicine, Internal Medicine (1993)
- MD, Yale University, MD, Cum Laude (1989)
- MA, Stanford University, East Asian Studies (1984)
- BAS, Stanford University, Biology and East Asian Studies (1984)
Honors & Awards
- Activation of patient-specific endogenous myocardial repair through the exosomes, California Institute for Regenerative Medicine (2016-2017)
- Bissett Lecture, University of Arkansas School of Medicine (2018)
- Cardiovascular Molecular Biologic Therapy Research Network Principal Investigator, National Institutes of Health (2012)
- Career Development Award, National Institute of Health (2000)
- Cell Characterization and Imaging for Molecular Therapies in Ischemic Diseases, National Institutes of Health (2012-2019)
- Co-Chair and Organizer, Frontiers in Cardiovascular Medicine, Stanford-Gachon 2nd Annual Session,, Gachon University (2016-2019)
- Co-Chair, Frontiers in Cardiovascular Medicine, Gachon University, Incheon, Korea (2014)
- Cum Laude, Yale University School of Medicine (1989)
- Edwin L Alderman Award for Excellence in Research, Stanford Cardiovascular Medicine (1999)
- Glaxo Smith Kline Scholar, American Federation of Medical Research (2003)
- Judge, Young Investigator Awards Competition: Physiology, Pharmacology, and Pathology, American College of Cardiology (2008)
- K18 Career Enhancement Award, National Institutes of Health (2007)
- K23 Career Development Award, National Institute of Health (2000)
- K24 Mid-Career Award in Patient-Oriented Research, National Institute of Health (2016-2021)
- Melvin Judkins Young Investigator Award, 1st Place, senior author, American Heart Association (2009)
- Melvin Judkins Young Investigator Award, 1st Place, senior author, American Heart Association (2010)
- Melvin Judkins Young Investigator Award, 1st Place, senior author, American Heart Association (2011)
- Melvin Judkins Young Investigator Award, 1st Place, senior author, American Heart Association (2012)
- Melvin Marcus YIA, Finalist, Senior Author, American Heart Association (2018)
- Physiology & Pharmacology Research Award, Stanford Cardiovascular Medicine (1997)
- Soloman's Scholarship, UCLA Dept of Medicine (1993)
- Teaching Award, Stanford University School of Medicine (2004)
- Tracking cardiac engraftment and viability of cell biologics by MRI, National Institutes of Health (2016-2017)
- Translational and Basic Science YIA, Finalist, Senior Author, American College of Cardiology (2020)
- Visiting Professor in Molecular Medicine, Jinan University, Guangzhou, China (2015)
- Vivien Thomas Young Investigator Award, American Heart Association (2005)
- Young Investigator Award, American College of Cardiology (1998)
- Young Investigator Award Finalist, senior author, American College of Cardiology (2015)
- Young Investigator Award, Finalist, American College of Cardiology (2007)
- Young Investigator Award, Finalist, American College of Cardiology (Senior Author) (2004)
- Young Investigator Award, Finalist, American College of Cardiology (Senior Author) (2005)
Memberships
- Reviewer, National Institute of Health Myocardial Ischemia and Metabolism (MIM) Study Section (2016 - Present)
- Co-Chair, American Heart Association Stem Cell Working Group (2015 - Present)
- Reviewer, Veterans Affairs, Cardiovascular Studies – A (CARA) panel, Merit Review meeting (2015 - 2016)
- Reviewer, National Institute of Health Clinical and Integrative Cardiovascular Sciences (CICS) Study Section, (2015 - 2016)
- Reviewer, National Institute of Health Cardiovascular and Respiratory Sciences IRG Special Emphasis (2015 - 2016)
- Reviewer, Department of Defense, Cardiovascular Health of the Defense Health Program, Investigator-Initiated Research Award (2015 - 2015)
- Reviewer, Veterans Affairs Office of Research and Development proposal (2015 - 2015)
- Member, American College of Cardiology, Annual Scientific Session Program Committee (2010 - 2012)
- Reviewer, National Institute Health, ARRA Challenge Grant Study Section (2009 - 2009)
- Reviewer, American Heart Association, National Center Grant Study Section – Radiology and Surgery (2004 - 2009)
- Reviewer, American Heart Association, Western Regional Grant Study Section – Cardiovascular Molecular and Cellular Imaging (2004 - 2009)
Administrative Appointments
- Assistant Professor, Stanford Division of Cardiovascular Medicine (2005 - 2012)
- Associate Professor, Stanford Division of Cardiovascular Medicine (2012 - 2020)
- Cardiology Fellow, Stanford Division of Cardiovascular Medicine (1994 - 1999)
- Clinical Instructor & Staff Physician, Stanford Division of Cardiovascular Medicine (1999 - 2005)
- Director, Cardiothoracic MRI Program, Stanford Division of Cardiovascular Medicine (2012 - Present)
- Director, Cardiovascular Stem Cell Laboratory, Stanford Division of Cardiovascular Medicine (2005 - Present)
- Professor, Stanford Division of Cardiovascular Medicine (2020 - Present)
Publications
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Rapid evaluation of left ventricular volume and mass without breath-holding using real-time interactive cardiac magnetic resonance imaging system
Kaji, S., Yang, P. C., Kerr, A. B., Tang, W. H. W., Meyer, C. H., Macovski, A., … Hu, B. S. (2001). Rapid evaluation of left ventricular volume and mass without breath-holding using real-time interactive cardiac magnetic resonance imaging system. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 38(2), 527–533. -
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Magnetic resonance coronary angiography.
Yang, P. C., McConnell, M. V., Nishimura, D. G., & Hu, B. S. (2003). Magnetic resonance coronary angiography. Current Cardiology Reports, 5(1), 55–62. -
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A visual approach for the accurate determination of echocardiographic left ventricular ejection fraction by medical students
Hope, M. D., de la Pena, E., Yang, P. C., Liang, D. H., McConnell, M. V., & Rosenthal, D. N. (2003). A visual approach for the accurate determination of echocardiographic left ventricular ejection fraction by medical students. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 16(8), 824–31. -
Noninvasive assessment of coronary vasodilation using magnetic resonance angiography
Terashima, M., Meyer, C. H., Keeffe, B. G., Putz, E. J., De La Pena-Almaguer, E., Yang, P. C., … McConnell, M. V. (2005). Noninvasive assessment of coronary vasodilation using magnetic resonance angiography. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 45(1), 104–110. -
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Dynamic real-time architecture in magnetic resonance coronary angiography-a prospective clinical trial
Yang, P. C., Santos, J. M., Nguyen, P. K., Scott, G. C., Engvall, J., McConnell, M. V., … Hu, B. S. (2004). Dynamic real-time architecture in magnetic resonance coronary angiography-a prospective clinical trial. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 6(4), 885–894. -
POsitive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles
Cunningham, C. H., Arai, T., Yang, P. C., McConnell, M. V., Pauly, J. M., & Conolly, S. M. (2005). POsitive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. MAGNETIC RESONANCE IN MEDICINE, 53(5), 999–1005. -
Early diagnosis of hemochromatosis-related cardiomyopathy with magnetic resonance imaging
Ptaszek, L. M., Price, E. T., Hu, M. Y., & Yang, P. C. (2005). Early diagnosis of hemochromatosis-related cardiomyopathy with magnetic resonance imaging. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 7(4), 689–692. -
High-resolution real-time spiral MRI for guiding vascular interventions in a rabbit model at 1.5 T.
Terashima, M., Hyon, M. S., de la Pena-Almaguer, E., Yang, P. C., Hu, B. S., Nayak, K. S., … McConnell, M. V. (2005). High-resolution real-time spiral MRI for guiding vascular interventions in a rabbit model at 1.5 T. Journal of Magnetic Resonance Imaging : JMRI, 22(5), 687–690. -
Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 T
Arai, T., Kofidis, T., Bulte, J. W. M., de Bruin, J., Venook, R. D., Berry, G. J., … Yang, P. C. (2006). Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 T. MAGNETIC RESONANCE IN MEDICINE, 55(1), 203–209. -
Images in cardiovascular medicine. Cardiac magnetic resonance imaging for myocarditis: effective use in medical decision making.
Fenster, B. E., Chan, F. P., Valentine, H. A., Yang, E., McConnell, M. V., Berry, G. J., & Yang, P. C. (2006). Images in cardiovascular medicine. Cardiac magnetic resonance imaging for myocarditis: effective use in medical decision making. Circulation, 113(22), e842–3. -
Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts
Kutschka, I., Chen, I. Y., Kofidis, T., Arai, T., von Degenfeld, G., Sheikh, A. Y., … Robbins, R. C. (2006). Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts. Presented at the 78th Annual Scientific Session of the American-Heart-Association, DALLAS,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX,TX: LIPPINCOTT WILLIAMS & WILKINS. -
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FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents
Seo, W. S., Lee, J. H., Sun, X., Suzuki, Y., Mann, D., Liu, Z., … Dai, H. (2006). FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents. NATURE MATERIALS, 5(12), 971–976. -
Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse
Yue, P., Arai, T., Terashima, M., Sheikh, A. Y., Cao, F., Charo, D., … Tsao, P. S. (2007). Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 292(5), H2106–H2118. -
Cardiovascular MRI for stem cell therapy.
Suzuki, Y., Yeung, A. C., & Yang, P. C. (2007). Cardiovascular MRI for stem cell therapy. Current Cardiology Reports, 9(1), 45–50. -
Indirect magnetic resonance lymphangiography to assess lymphatic function in experimental murine lymphedema.
Pan, D., Suzuki, Y., Yang, P. C., & Rockson, S. G. (2006). Indirect magnetic resonance lymphangiography to assess lymphatic function in experimental murine lymphedema. Lymphatic Research and Biology, 4(4), 211–216. -
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Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects
Li, Z., Suzuki, Y., Huang, M., Cao, F., Xie, X., Connolly, A. J., … Wu, J. C. (2008). Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects. STEM CELLS, 26(4), 864–873. -
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Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells
Hendry, S. L., van der Bogt, K. E. A., Sheikh, A. Y., Arai, T., Dylla, S. J., Drukker, M., … Yang, P. C. (2008). Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 136(4), 1028–U14. -
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In vitro labeling of human embryonic stem cells for magnetic resonance imaging.
Yamada, M., & Yang, P. (2008). In vitro labeling of human embryonic stem cells for magnetic resonance imaging. Journal of Visualized Experiments : JoVE, (17). -
In vitro differentiation of mouse embryonic stem (mES) cells using the hanging drop method.
Wang, X., & Yang, P. (2008). In vitro differentiation of mouse embryonic stem (mES) cells using the hanging drop method. Journal of Visualized Experiments : JoVE, (17). -
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Manganese-Guided Cellular MRI of Human Embryonic Stem Cell and Human Bone Marrow Stromal Cell Viability
Yamada, M., Gurney, P. T., Chung, J., Kundu, P., Drukker, M., Smith, A. K., … Yang, P. C. (2009). Manganese-Guided Cellular MRI of Human Embryonic Stem Cell and Human Bone Marrow Stromal Cell Viability. MAGNETIC RESONANCE IN MEDICINE, 62(4), 1047–1054. -
Magnetic resonance imaging of human embryonic stem cells.
Chung, J., Yamada, M., & Yang, P. C. (2009). Magnetic resonance imaging of human embryonic stem cells. Current Protocols in Stem Cell Biology, Chapter 5, Unit 5A 3-? -
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Molecular Imaging of Stem Cell Transplantation in Myocardial Disease.
Chung, J., & Yang, P. C. (2010). Molecular Imaging of Stem Cell Transplantation in Myocardial Disease. Current Cardiovascular Imaging Reports, 3(2), 106–12. -
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Human ESC vs. iPSC-Pros and Cons
Pappas, J. J., & Yang, P. C. (2008). Human ESC vs. iPSC-Pros and Cons. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(2), 96–99. -
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RevaTen platelet-rich plasma improves cardiac function after myocardial injury.
Mishra, A., Velotta, J., Brinton, T. J., Wang, X., Chang, S., Palmer, O., … Fischbein, M. (2011). RevaTen platelet-rich plasma improves cardiac function after myocardial injury. Cardiovascular Revascularization Medicine : Including Molecular Interventions, 12(3), 158–63. -
A Molecular MRI Probe to Detect Treatment of Cardiac Apoptosis In Vivo
Dash, R., Chung, J., Chan, T., Yamada, M., Barral, J., Nishimura, D., … Simpson, P. C. (2011). A Molecular MRI Probe to Detect Treatment of Cardiac Apoptosis In Vivo. MAGNETIC RESONANCE IN MEDICINE, 66(4), 1152–62. -
In vivo Molecular MRI of Cell Survival and Teratoma Formation Following Embryonic Stem Cell Transplantation Into the Injured Murine Myocardium
Chung, J., Kee, K., Barral, J. K., Dash, R., Kosuge, H., Wang, X., … Yang, P. C. (2011). In vivo Molecular MRI of Cell Survival and Teratoma Formation Following Embryonic Stem Cell Transplantation Into the Injured Murine Myocardium. MAGNETIC RESONANCE IN MEDICINE, 66(5), 1374–81. -
alpha B-Crystallin Improves Murine Cardiac Function and Attenuates Apoptosis in Human Endothelial Cells Exposed to Ischemia-Reperfusion
Velotta, J. B., Kimura, N., Chang, S. H., Chung, J., Itoh, S., Rothbard, J., … Fischbein, M. P. (2011). alpha B-Crystallin Improves Murine Cardiac Function and Attenuates Apoptosis in Human Endothelial Cells Exposed to Ischemia-Reperfusion. ANNALS OF THORACIC SURGERY, 91(6), 1907–13. -
Dual Manganese-Enhanced and Delayed Gadolinium-Enhanced MRI Detects Myocardial Border Zone Injury in a Pig Ischemia-Reperfusion Model
Dash, R., Chung, J., Ikeno, F., Hahn-Windgassen, A., Matsuura, Y., Bennett, M. V., … Yang, P. C. (2011). Dual Manganese-Enhanced and Delayed Gadolinium-Enhanced MRI Detects Myocardial Border Zone Injury in a Pig Ischemia-Reperfusion Model. CIRCULATION-CARDIOVASCULAR IMAGING, 4(5), 574–82. -
Contrast echocardiography: finding its place in stem cell therapy
Kim, P. J., & Yang, P. C. (2011). Contrast echocardiography: finding its place in stem cell therapy. MINERVA CARDIOANGIOLOGICA, 59(5), 491–497. -
Theranostic effect of serial manganese-enhanced magnetic resonance imaging of human embryonic stem cell derived teratoma
Chung, J., Dash, R., Kee, K., Barral, J. K., Kosuge, H., Robbins, R. C., … Yang, P. C. (2012). Theranostic effect of serial manganese-enhanced magnetic resonance imaging of human embryonic stem cell derived teratoma. MAGNETIC RESONANCE IN MEDICINE, 68(2), 595–99. -
Determinants of Left Ventricular Mass in Patients on Hemodialysis Frequent Hemodialysis Network (FHN) Trials
Chan, C. T., Greene, T., Chertow, G. M., Kliger, A. S., Stokes, J. B., Beck, G. J., … Rajagopalan, S. (2012). Determinants of Left Ventricular Mass in Patients on Hemodialysis Frequent Hemodialysis Network (FHN) Trials. CIRCULATION-CARDIOVASCULAR IMAGING, 5(2), 251–261. -
Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells.
Ge, X., Wang, I.-N. E., Toma, I., Sebastiano, V., Liu, J. W., Butte, M. J., … Yang, P. C. (2012). Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells. Stem Cells and Development, 21(15), 2798–2808. -
Bone marrow cell therapy in clinical trials: a review of the literature.
Kim, P. J., & Yang, P. C. (2012). Bone marrow cell therapy in clinical trials: a review of the literature. Reviews on Recent Clinical Trials, 7(3), 204–213. -
Apelin Enhances Directed Cardiac Differentiation of Mouse and Human Embryonic Stem Cells
Wang, I.-N. E., Wang, X., Ge, X., Anderson, J., Ho, M., Ashley, E., … Yang, P. C. (2012). Apelin Enhances Directed Cardiac Differentiation of Mouse and Human Embryonic Stem Cells. PLOS ONE, 7(6). -
Is Reliable In Vivo Detection of Stem Cell Viability Possible in a Large Animal Model of Myocardial Injury?
Yang, P. C. (2012). Is Reliable In Vivo Detection of Stem Cell Viability Possible in a Large Animal Model of Myocardial Injury? CIRCULATION, 126(4), 388–390. -
Synthesis of an in vivo MRI-detectable apoptosis probe.
Lam, J., Simpson, P. C., Yang, P. C., & Dash, R. (2012). Synthesis of an in vivo MRI-detectable apoptosis probe. Journal of Visualized Experiments : JoVE, (65). -
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High-resolution real-time magnetic resonance imaging for vascular interventions.
Terashima, M., De La Pena-Almaguer, E., Nayak, K., Pauly, J. M., Yang, P. C., Hu, B. S., & McConnell, M. V. (2001). High-resolution real-time magnetic resonance imaging for vascular interventions. AMERICAN JOURNAL OF CARDIOLOGY, 88(5A), 89G–89G. -
Phase II Clinical Research Design in Cardiology Learning the Right Lessons Too Well: Observations and Recommendations From the Cardiovascular Cell Therapy Research Network (CCTRN)
Hare, J. M., Bolli, R., Cooke, J. P., Gordon, D. J., Henry, T. D., Perin, E. C., … Moye, L. A. (2013). Phase II Clinical Research Design in Cardiology Learning the Right Lessons Too Well: Observations and Recommendations From the Cardiovascular Cell Therapy Research Network (CCTRN). CIRCULATION, 127(15), 1630–1635. -
Magnetic resonance imaging of myocardial viability predicts future cardiovascular events in patients with severe ischemic cardiomyopathy
Tsukiji, M., Nguyen, P., Narayan, G., Hellinger, J., Chan, F. P., Herfkens, R., … Yang, P. C. (2005). Magnetic resonance imaging of myocardial viability predicts future cardiovascular events in patients with severe ischemic cardiomyopathy. CIRCULATION, 112(17), U529–U530. -
NTG-enhanced coronary MRA: Improved SNR and vasodilation time course
Terashima, M., Keeffe, B. G., Putz, E. J., Yang, P. C., De La Pena-Almaguer, E., Hu, B. S., … McConnell, M. V. (2002). NTG-enhanced coronary MRA: Improved SNR and vasodilation time course. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5), 218A–218A. -
Contrast-enhanced MRI demonstrates acute response to vascular injury
Terashima, M., De La Pena-Almaguer, E., Yang, P. C., Hu, B. S., & McConnell, M. V. (2002). Contrast-enhanced MRI demonstrates acute response to vascular injury. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5), 389A–389A. -
In vivo magnetic resonance evaluation of the effects of mouse embryonic stem cells on cardiac function
Arai, T., de Bruin, J., Kofidis, T., Venook, R., McConnell, M. V., Quertermous, T., … Yang, P. C. (2004). In vivo magnetic resonance evaluation of the effects of mouse embryonic stem cells on cardiac function. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 43(5), 532A–532A. -
Peri-infarct ischemia determined by comprehensive MR evaluation of myocardial viability and stress perfusion predicts future cardiovascular events in patients with severe ischemic cardiomyopathy
Tsukiji, M., Nguyen, P., Narayan, G., Hellinger, J., Chan, F., Herfkens, R., … Yang, P. (2005). Peri-infarct ischemia determined by comprehensive MR evaluation of myocardial viability and stress perfusion predicts future cardiovascular events in patients with severe ischemic cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 45(3), 446A–446A. -
Cardiac magnetic resonance imaging for myocarditis - Effective use in medical decision making
Fenster, B. E., Chan, F. P., Valentine, H. A., Yang, E., McConnell, M. V., Berry, G. J., & Yang, P. C. (2006). Cardiac magnetic resonance imaging for myocarditis - Effective use in medical decision making. CIRCULATION, 113(22), E842–E843. -
Cardiovascular Magnetic Resonance Imaging Elucidates Genotype-Phenotype Relationships in Patients with Hypertrophic Cardiomyopathy
Heidary, S., Wheeler, M. T., Bennett, M. V., Chung, J., Pavlovic, A., Parent, M.-C., … Yang, P. C. (2011). Cardiovascular Magnetic Resonance Imaging Elucidates Genotype-Phenotype Relationships in Patients with Hypertrophic Cardiomyopathy. CIRCULATION, 124(21). -
Detection of Injured Border Zone Myocardium Using Manganese-Enhanced and Delayed-Enhanced MRI in a Pig Ischemia-Reperfusion Model
Dash, R., Chung, J., Hahn-Windgassen, A., Matsuura, Y., Ikeno, F., Lyons, J., … Yang, P. C. (2010). Detection of Injured Border Zone Myocardium Using Manganese-Enhanced and Delayed-Enhanced MRI in a Pig Ischemia-Reperfusion Model. CIRCULATION, 122(21). -
SUSTAINED RESTORATION OF LV FUNCTION IN A PORCINE ISCHEMIA-REPERFUSION INJURY MODEL USING HUMAN PLACENTAL MESENCHYMAL STEM CELLS AND MANGANESE-ENHANCED MRI
Dash, R., Kim, P., Matsuura, Y., Ikeno, F., Lyons, J., Ge, X., … Yang, P. (2013). SUSTAINED RESTORATION OF LV FUNCTION IN A PORCINE ISCHEMIA-REPERFUSION INJURY MODEL USING HUMAN PLACENTAL MESENCHYMAL STEM CELLS AND MANGANESE-ENHANCED MRI. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10), E1142–E1142. -
In vivo Kinetics of Embryonic Stem Cell Viability Following Transplantation Into the Injured Murine Myocardium
Chung, J., Kee, K., Barral, J. K., Dash, R., Weissman, I., Quertermous, T., … Yang, P. C. (2009). In vivo Kinetics of Embryonic Stem Cell Viability Following Transplantation Into the Injured Murine Myocardium. CIRCULATION, 120(18), S310–S311. -
REGENERATIVE CHANGES OF THE PERI-INFARCT INJURY ALLOWS SUSTAINED RESTORATION OF THE INJURED MYOCARDIUM
Kim, P., Gong, Y., Ge, X., Harnish, P., Dash, R., Robbins, R., & Yang, P. (2013). REGENERATIVE CHANGES OF THE PERI-INFARCT INJURY ALLOWS SUSTAINED RESTORATION OF THE INJURED MYOCARDIUM. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10), E1074–E1074. -
DUAL CONTRAST CARDIAC MRI FOR EVALUATION OF TELMISARTAN AND AMLODIPINE COMBINATION THERAPY IN THE DIABETIC MURINE MYOCARDIAL INJURY MODEL
Kim, P., Gong, Y., Harnish, P., Toma, I., Dash, R., Robbins, R., & Yang, P. (2013). DUAL CONTRAST CARDIAC MRI FOR EVALUATION OF TELMISARTAN AND AMLODIPINE COMBINATION THERAPY IN THE DIABETIC MURINE MYOCARDIAL INJURY MODEL. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10), E941–E941. -
VALIDATION OF INFARCT CHARACTERIZATION IN A PORCINE ISCHEMIA REPERFUSION INJURY MODEL
Nakagawa, K., Ikeno, F., Matsuura, Y., Lyons, J., Nguyen, P., Wu, J., … Dash, R. (2013). VALIDATION OF INFARCT CHARACTERIZATION IN A PORCINE ISCHEMIA REPERFUSION INJURY MODEL. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10), E617–E617. -
Myocardial restoration with embryonic stem cell transplantation in a murine myocardial infarction model
Hendry, S. L., Arai, T., Dylla, S. J., Drukker, M., Sheikh, A. Y., Kutschka, I., … Robbins, R. C. (2005). Myocardial restoration with embryonic stem cell transplantation in a murine myocardial infarction model. CIRCULATION, 112(17), U37–U38. -
Myocardial restoration with embryonic stem cell transplantation in a murine myocardial infarction model
Hendry, S. L., Arai, T., Dylla, S. J., Drukker, M., Sheikh, A. Y., Kutschka, I., … Robbins, R. C. (2005). Myocardial restoration with embryonic stem cell transplantation in a murine myocardial infarction model. CIRCULATION, 112(17), U432–U432. -
Apelin Enhances Cardiac Differentiation of Human Embryonic Stem Cells
Wang, I.-N. E., Chung, J., & Yang, P. C. (2010). Apelin Enhances Cardiac Differentiation of Human Embryonic Stem Cells. CIRCULATION, 122(21). -
Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.
Lancellotti, P., Nkomo, V. T., Badano, L. P., Bergler-Klein, J., Bogaert, J., Davin, L., … Yang, P. C. (2013). Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. European Heart Journal Cardiovascular Imaging, 14(8), 721–740. -
A case of recurrent pericardial constriction presenting with severe pulmonary hypertension.
Brunner, N. W., Ramachandran, K., Kudelko, K. T., Sung, Y. K., Spiekerkoetter, E., Yang, P. C., … Perez, V. deJ. (2013). A case of recurrent pericardial constriction presenting with severe pulmonary hypertension. Pulmonary Circulation, 3(2), 436–39. -
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Nonrigid autofocus motion correction for coronary MR angiography with a 3D cones trajectory.
Ingle, R. R., Wu, H. H., Addy, N. O., Cheng, J. Y., Yang, P. C., Hu, B. S., & Nishimura, D. G. (2014). Nonrigid autofocus motion correction for coronary MR angiography with a 3D cones trajectory. Magnetic Resonance in Medicine , 72(2), 347–361. -
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Effects of Frequent Hemodialysis on Ventricular Volumes and Left Ventricular Remodeling
Chan, C. T., Greene, T., Chertow, G. M., Kliger, A. S., Stokes, J. B., Beck, G. J., … Rajagopalan, S. (2013). Effects of Frequent Hemodialysis on Ventricular Volumes and Left Ventricular Remodeling. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 8(12), 2106–2116. -
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Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes.
PW, B., SA, M., KH, N., OJ, A., CS, S., MA, B., … PC, Y. (2014). Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes. Am J Transl Res , 6(6). -
Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes.
Burridge, P. W., Metzler, S. A., Nakayama, K. H., Abilez, O. J., Simmons, C. S., Bruce, M. A., … Yang, P. C. (2014). Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes. American Journal of Translational Research, 6(6), 724–35. -
Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium.
Kim, P. J., Mahmoudi, M., Ge, X., Matsuura, Y., Toma, I., Metzler, S., … Yang, P. C. (2015). Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium. Circulation Research, 116(7), e40–50. -
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells
Gao, Y., Yang, P., Shen, H., Yu, H., Song, X., Zhang, L., … Xie, X.-Q. (2015). Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells. NATURE COMMUNICATIONS, 6. -
Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension.
Spiekerkoetter, E., Sung, Y. K., Sudheendra, D., Bill, M., Aldred, M. A., van de Veerdonk, M. C., … Zamanian, R. T. (2015). Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 192(2), 254–57. -
Immunologic Network and Response to Intramyocardial CD34(+) Stem Cell Therapy in Patients With Dilated Cardiomyopathy
Haddad, F., Sever, M., Poglajen, G., Lezaic, L., Yang, P., Maecker, H., … Vrtovec, B. (2015). Immunologic Network and Response to Intramyocardial CD34(+) Stem Cell Therapy in Patients With Dilated Cardiomyopathy. JOURNAL OF CARDIAC FAILURE, 21(7), 572–582. -
Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia-Reperfusion Model.
Dash, R., Kim, P. J., Matsuura, Y., Ikeno, F., Metzler, S., Huang, N. F., … Yang, P. C. (2015). Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia-Reperfusion Model. Journal of the American Heart Association, 4(7). -
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Epicardial FSTL1 reconstitution regenerates the adult mammalian heart.
Wei, K., Serpooshan, V., Hurtado, C., Diez-Cuñado, M., Zhao, M., Maruyama, S., … Ruiz-Lozano, P. (2015). Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature, 525(7570), 479–85. -
Concise Review: Review and Perspective of Cell Dosage and Routes of Administration From Preclinical and Clinical Studies of Stem Cell Therapy for Heart Disease
Golpanian, S., Schulman, I. H., Ebert, R. F., Heldman, A. W., Difede, D. L., Yang, P. C., … Hare, J. M. (2016). Concise Review: Review and Perspective of Cell Dosage and Routes of Administration From Preclinical and Clinical Studies of Stem Cell Therapy for Heart Disease. STEM CELLS TRANSLATIONAL MEDICINE, 5(2), 186–191. -
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Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia-Reperfusion Model.
Dash, R., Kim, P. J., Matsuura, Y., Ikeno, F., Metzler, S., Huang, N. F., … Yang, P. C. (2015). Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia-Reperfusion Model. Journal of the American Heart Association, 4(7). -
Telmisartan in the diabetic murine model of acute myocardial infarction: dual contrast manganese-enhanced and delayed enhancement MRI evaluation of the peri-infarct region.
Toma, I., Kim, P. J., Dash, R., McConnell, M. V., Nishimura, D., Harnish, P., & Yang, P. C. (2016). Telmisartan in the diabetic murine model of acute myocardial infarction: dual contrast manganese-enhanced and delayed enhancement MRI evaluation of the peri-infarct region. Cardiovascular Diabetology, 15(1), 24-? -
Rationale and Design of Sodium Tanshinone IIA Sulfonate in Left Ventricular Remodeling Secondary to Acute Myocardial Infarction (STAMP-REMODELING) Trial: A Randomized Controlled Study
Mao, S., Li, X., Wang, L., Yang, P. C., & Zhang, M. (2015). Rationale and Design of Sodium Tanshinone IIA Sulfonate in Left Ventricular Remodeling Secondary to Acute Myocardial Infarction (STAMP-REMODELING) Trial: A Randomized Controlled Study. CARDIOVASCULAR DRUGS AND THERAPY, 29(6), 535–42. -
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Novel MRI Contrast Agent from Magnetotactic Bacteria Enables In Vivo Tracking of iPSC-derived Cardiomyocytes.
Mahmoudi, M., Tachibana, A., Goldstone, A. B., Woo, Y. J., Chakraborty, P., Lee, K. R., … Yang, P. C. (2016). Novel MRI Contrast Agent from Magnetotactic Bacteria Enables In Vivo Tracking of iPSC-derived Cardiomyocytes. Scientific Reports, 6, 26960-? -
Challenging the complementarity of different metrics of left atrial function: insight from a cardiomyopathy-based study.
Kobayashi, Y., Moneghetti, K. J., Boralkar, K., Amsallem, M., Tuzovic, M., Liang, D., … Haddad, F. (2016). Challenging the complementarity of different metrics of left atrial function: insight from a cardiomyopathy-based study. European Heart Journal Cardiovascular Imaging. -
Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part II. In Vivo Imaging of Bone Marrow Stromal Cells in Swine with PET/CT and MR Imaging.
Parashurama, N., Ahn, B.-C., Ziv, K., Ito, K., Paulmurugan, R., Willmann, J. K., … Gambhir, S. S. (2016). Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part II. In Vivo Imaging of Bone Marrow Stromal Cells in Swine with PET/CT and MR Imaging. Radiology, 280(3), 826–36. -
Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part I. Reporter Gene Design, Characterization, and Optical in Vivo Imaging of Bone Marrow Stromal Cells after Myocardial Infarction.
Parashurama, N., Ahn, B.-C., Ziv, K., Ito, K., Paulmurugan, R., Willmann, J. K., … Gambhir, S. S. (2016). Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part I. Reporter Gene Design, Characterization, and Optical in Vivo Imaging of Bone Marrow Stromal Cells after Myocardial Infarction. Radiology, 280(3), 815–25. -
Aligned nanofibrillar collagen scaffolds - Guiding lymphangiogenesis for treatment of acquired lymphedema.
Hadamitzky, C., Zaitseva, T. S., Bazalova-Carter, M., Paukshto, M. V., Hou, L., Strassberg, Z., … Huang, N. F. (2016). Aligned nanofibrillar collagen scaffolds - Guiding lymphangiogenesis for treatment of acquired lymphedema. Biomaterials, 102, 259–67. -
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Apelin-13 infusion salvages the peri-infarct region to preserve cardiac function after severe myocardial injury
Chung, W.-J., Cho, A., Byun, K., Moon, J., Ge, X., Seo, H.-S., … Yang, P. C. (2016). Apelin-13 infusion salvages the peri-infarct region to preserve cardiac function after severe myocardial injury. INTERNATIONAL JOURNAL OF CARDIOLOGY, 222, 361–367. -
3D image-based navigators for coronary MR angiography.
Addy, N. O., Ingle, R. R., Luo, J., Baron, C. A., Yang, P. C., Hu, B. S., & Nishimura, D. G. (2016). 3D image-based navigators for coronary MR angiography. Magnetic Resonance in Medicine. -
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Efficacy of Danlou Tablet in Patients with Non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Results from a Multicentre, Placebo-Controlled, Randomized Trial
Wang, L., Zhao, X., Mao, S., Liu, S., Guo, X., Guo, L., … Zhang, M. (2016). Efficacy of Danlou Tablet in Patients with Non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Results from a Multicentre, Placebo-Controlled, Randomized Trial. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. -
Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials
Contreras, A., Orozco, A. F., Resende, M., Schutt, R. C., Traverse, J. H., Henry, T. D., … Taylor, D. A. (2017). Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials. BASIC RESEARCH IN CARDIOLOGY, 112(1). -
Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart Muscles
Qin, X., Riegler, J., Tiburcy, M., Zhao, X., Chour, T., Ndoye, B., … Wu, J. C. (2016). Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart Muscles. CIRCULATION-CARDIOVASCULAR IMAGING, 9(11). -
Baseline assessment and comparison of arterial anatomy, hyperemic flow, and skeletal muscle perfusion in peripheral artery disease: The Cardiovascular Cell Therapy Research Network "Patients with Intermittent Claudication Injected with ALDH Bright Cells" (CCTRN PACE) study
Venkatesh, B. A., Nauffal, V., Noda, C., Fujii, T., Yang, P. C., Bettencourt, J., … Lima, J. A. C. (2017). Baseline assessment and comparison of arterial anatomy, hyperemic flow, and skeletal muscle perfusion in peripheral artery disease: The Cardiovascular Cell Therapy Research Network "Patients with Intermittent Claudication Injected with ALDH Bright Cells" (CCTRN PACE) study. AMERICAN HEART JOURNAL, 183, 24–34. -
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Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial.
Perin, E. C., Murphy, M. P., March, K. L., Bolli, R., Loughran, J., Yang, P. C., … Hirsch, A. T. (2017). Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial. Circulation. -
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A PET/MR Imaging Approach for the Integrated Assessment of Chemotherapy-induced Brain, Heart, and Bone Injuries in Pediatric Cancer Survivors: A Pilot Study.
Theruvath, A. J., Ilivitzki, A., Muehe, A., Theruvath, J., Gulaka, P., Kim, C., … Daldrup-Link, H. E. (2017). A PET/MR Imaging Approach for the Integrated Assessment of Chemotherapy-induced Brain, Heart, and Bone Injuries in Pediatric Cancer Survivors: A Pilot Study. Radiology, 170073. -
The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications.
Youssef, A. A., Ross, E. G., Bolli, R., Pepine, C. J., Leeper, N. J., & Yang, P. C. (2016). The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. JACC. Basic to Translational Science, 1(6), 510–23. -
The Protein Corona around Nanoparticles Facilitates Stem Cell Labeling for Clinical MR Imaging.
Nejadnik, H., Taghavi-Garmestani, S.-M. M., Madsen, S. J., Li, K., Zanganeh, S., Yang, P., … Daldrup-Link, H. E. (2017). The Protein Corona around Nanoparticles Facilitates Stem Cell Labeling for Clinical MR Imaging. Radiology, 170130. -
Collagen matrices enhance survival of embryonic cardiomyoblasts following transplantation into ischemic rat hearts
Kutschka, Kofidis, T., Chen, I. Y., Arai, T., Sheikh, A. Y., Hendry, S. L., … Robbins, R. C. (2005). Collagen matrices enhance survival of embryonic cardiomyoblasts following transplantation into ischemic rat hearts. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. -
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Rationale and Design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit(+) Cardiac Stem Cells As Regenerative Therapy for Heart Failure)
Bolli, R., Hare, J. M., March, K. L., Pepine, C. J., Willerson, J. T., Perin, E. C., … Simari, R. D. (2018). Rationale and Design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit(+) Cardiac Stem Cells As Regenerative Therapy for Heart Failure). CIRCULATION RESEARCH, 122(12), 1703–15. -
Whole-heart coronary MR angiography using a 3D cones phyllotaxis trajectory.
Malave, M. O., Baron, C. A., Addy, N. O., Cheng, J. Y., Yang, P. C., Hu, B. S., & Nishimura, D. G. (2018). Whole-heart coronary MR angiography using a 3D cones phyllotaxis trajectory. Magnetic Resonance in Medicine. -
TARGETED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES FACILITATE ENGRAFTMENT OF THE IPSC-DERIVED CARDIOMYOCYTES INTO THE INJURED MURINE MYOCARDIUM
Mahmoudi, M., Tachibana, A., Cohen, J., Goldstone, A., Edwards, B., Rulifson, E., … Yang, P. (2016). TARGETED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES FACILITATE ENGRAFTMENT OF THE IPSC-DERIVED CARDIOMYOCYTES INTO THE INJURED MURINE MYOCARDIUM. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13), 2126. -
EXOSOMES FROM THE HUMAN PLACENTA-DERIVED AMNIOTIC MESENCHYMAL STEM CELLS RESTORE THE INJURED MURINE MYOCARDIUM
Santoso, M., Mahmoudi, M., Tachibana, A., Sierra, R. G., Matsui, T., Goldstone, A., … Yang, P. (2016). EXOSOMES FROM THE HUMAN PLACENTA-DERIVED AMNIOTIC MESENCHYMAL STEM CELLS RESTORE THE INJURED MURINE MYOCARDIUM. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. ELSEVIER SCIENCE INC. -
Myocardial viability of the peri-infarct region measured by T1 mapping post manganese-enhanced MRI correlates with LV dysfunction.
Tada, Y., Heidary, S., Tachibana, A., Zaman, J., Neofytou, E., Dash, R., … Yang, P. C. (2019). Myocardial viability of the peri-infarct region measured by T1 mapping post manganese-enhanced MRI correlates with LV dysfunction. International Journal of Cardiology. -
MICROVESICLES LARGER THAN 200NM RESCUE CARDIOMYOCYTES FROM DOXORUBICIN INJURY IN A PATIENT-SPECIFIC MODEL OF ANTHRACYCLINE INDUCED CARDIOMYOPATHY
O'Brien, C., Shi, L., Ozgun, M., Vaskova, E., Santoso, M., Jung, J. H., … Yang, P. (2019). MICROVESICLES LARGER THAN 200NM RESCUE CARDIOMYOCYTES FROM DOXORUBICIN INJURY IN A PATIENT-SPECIFIC MODEL OF ANTHRACYCLINE INDUCED CARDIOMYOPATHY. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. ELSEVIER SCIENCE INC. -
Apelin reverses pathologic ventricular remodeling in the db/db obese mouse
Yue, P., Ernst, K., Terashima, M., Greve, J. M., Quertermous, T., Yang, P. C., & Tsao, P. S. (2006). Apelin reverses pathologic ventricular remodeling in the db/db obese mouse. CIRCULATION, 114(18), 174. -
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Protein Corona Influences Cell-Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds.
Serpooshan, V., Mahmoudi, M., Zhao, M., Wei, K., Sivanesan, S., Motamedchaboki, K., … Ruiz-Lozano, P. (2015). Protein Corona Influences Cell-Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds. Advanced Functional Materials, 25(28), 4379–4389. -
Rationale and Design of Sodium Tanshinone IIA Sulfonate in Left Ventricular Remodeling Secondary to Acute Myocardial Infarction (STAMP-REMODELING) Trial: A Randomized Controlled Study.
Mao, S., Li, X., Wang, L., Yang, P. C., & Zhang, M. (2015). Rationale and Design of Sodium Tanshinone IIA Sulfonate in Left Ventricular Remodeling Secondary to Acute Myocardial Infarction (STAMP-REMODELING) Trial: A Randomized Controlled Study. Cardiovascular Drugs and Therapy, 29(6), 535–542. -
Defining genotype-phenotype relationships in patients with hypertrophic cardiomyopathy using cardiovascular magnetic resonance imaging.
Miller, R. J., Heidary, S., Pavlovic, A., Schlachter, A., Dash, R., Fleischmann, D., … Yang, P. C. (2019). Defining genotype-phenotype relationships in patients with hypertrophic cardiomyopathy using cardiovascular magnetic resonance imaging. PloS One, 14(6), e0217612. -
Stem Cell-Derived Exosomes Protect Astrocyte Cultures From in vitro Ischemia and Decrease Injury as Post-stroke Intravenous Therapy
Sun, X., Jung, J.-H., Arvola, O., Santoso, M. R., Giffard, R. G., Yang, P. C., & Stary, C. M. (2019). Stem Cell-Derived Exosomes Protect Astrocyte Cultures From in vitro Ischemia and Decrease Injury as Post-stroke Intravenous Therapy. FRONTIERS IN CELLULAR NEUROSCIENCE, 13. -
Stem Cell-Derived Exosomes Protect Astrocyte Cultures From in vitro Ischemia and Decrease Injury as Post-stroke Intravenous Therapy.
Sun, X., Jung, J.-H. H., Arvola, O., Santoso, M. R., Giffard, R. G., Yang, P. C., & Stary, C. M. (2019). Stem Cell-Derived Exosomes Protect Astrocyte Cultures From in vitro Ischemia and Decrease Injury as Post-stroke Intravenous Therapy. Frontiers in Cellular Neuroscience, 13, 394. -
Broad Genetic Testing in a Clinical Setting Uncovers a High Prevalence of Titin Loss-of-Function Variants in Very Early-Onset Atrial Fibrillation.
Goodyer, W. R., Dunn, K., Caleshu, C., Jackson, M., Wylie, J., Moscarello, T., … Perez, M. (2019). Broad Genetic Testing in a Clinical Setting Uncovers a High Prevalence of Titin Loss-of-Function Variants in Very Early-Onset Atrial Fibrillation. Circulation. Genomic and Precision Medicine. -
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Meta-analysis of short- and long-term efficacy of mononuclear cell transplantation in patients with myocardial infarction.
Yang, D., O'Brien, C. G., Ikeda, G., Traverse, J. H., Taylor, D. A., Henry, T. D., … Yang, P. C. (2019). Meta-analysis of short- and long-term efficacy of mononuclear cell transplantation in patients with myocardial infarction. American Heart Journal, 220, 155–75. -
Ferumoxytol-enhanced cardiovascular magnetic resonance detection of early stage acute myocarditis.
Tada, Y., Tachibana, A., Heidary, S., Yang, P. C., McConnell, M. V., & Dash, R. (2019). Ferumoxytol-enhanced cardiovascular magnetic resonance detection of early stage acute myocarditis. Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance, 21(1), 77. -
Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography.
Spath, N., Tavares, A., Gray, G. A., Baker, A. H., Lennen, R. J., Alcaide-Corral, C. J., … Semple, S. I. (2020). Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography. Scientific Reports, 10(1), 2018. -
Iron Oxide Labeling and Tracking of Extracellular Vesicles
Tada, Y., & Yang, P. C. (2019). Iron Oxide Labeling and Tracking of Extracellular Vesicles. MAGNETOCHEMISTRY, 5(4). -
Exosomes From Induced Pluripotent Stem Cell-Derived Cardiomyocytes Promote Autophagy for Myocardial Repair.
Santoso, M. R., Ikeda, G., Tada, Y., Jung, J.-H., Vaskova, E., Sierra, R. G., … Yang, P. C. (2020). Exosomes From Induced Pluripotent Stem Cell-Derived Cardiomyocytes Promote Autophagy for Myocardial Repair. Journal of the American Heart Association, 9(6), e014345. -
SULFATED DEXTRAN-COATED IRON OXIDE NANOPARTICLES DETECT INFLAMMATION IN THE PERI-INFARCT REGION POST-ACUTE MYOCARDIAL INFARCTION
Tada, Y., Ikeda, G., Louie, A., & Yang, P. (2020). SULFATED DEXTRAN-COATED IRON OXIDE NANOPARTICLES DETECT INFLAMMATION IN THE PERI-INFARCT REGION POST-ACUTE MYOCARDIAL INFARCTION. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 75(11), 1792. -
MITOCHONDRIA CONTAINING EXTRACELLULAR VESICLES FROM AUTOLOGOUS INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTES RESTORE BIOENERGETICS IN ISCHEMIC MYOCARDIUM
Ikeda, G., Santoso, M., Tada, Y., Vaskova, E., O'Brien, C. G., Jung, J. H., & Yang, P. C. (2020). MITOCHONDRIA CONTAINING EXTRACELLULAR VESICLES FROM AUTOLOGOUS INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTES RESTORE BIOENERGETICS IN ISCHEMIC MYOCARDIUM. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 75(11), 3659. -
Exosomal miR-106a-363 Cluster Repairs the Injured Myocardium
Jung, J. H., Tada, Y., Wahlquist, C., Bornstadt, D., Santoso, M., Woo, J., … Yang, P. (2018). Exosomal miR-106a-363 Cluster Repairs the Injured Myocardium. CIRCULATION, 138. -
Exosomes From Induced Pluripotent Stem Cell-Derived Cardiomyocytes Salvage the Injured Myocardium by Modulation of Autophagy
Santoso, M. R., Tada, Y., Ikeda, G., Jung, J.-H., Vaskova, E., Sierra, R. G., … Yang, P. C. (2018). Exosomes From Induced Pluripotent Stem Cell-Derived Cardiomyocytes Salvage the Injured Myocardium by Modulation of Autophagy. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. -
Sacubitril/Valsartan Improves Cardiac Function and Decreases Myocardial Fibrosis Via Downregulation of Exosomal miR-181a in a Rodent Chronic Myocardial Infarction Model.
Vaskova, E., Ikeda, G., Tada, Y., Wahlquist, C., Mercola, M., & Yang, P. C. (2020). Sacubitril/Valsartan Improves Cardiac Function and Decreases Myocardial Fibrosis Via Downregulation of Exosomal miR-181a in a Rodent Chronic Myocardial Infarction Model. Journal of the American Heart Association, e015640. -
Mitochondria-Containing Extracellular Vesicles Restore Intracellular ATP Production and Promote Viability in Injured Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Ikeda, G., Santoso, M. R., Tada, Y., Vaskova, E., Jung, J.-H., Galen, C. O., … Yang, P. (2018). Mitochondria-Containing Extracellular Vesicles Restore Intracellular ATP Production and Promote Viability in Injured Induced Pluripotent Stem Cell-Derived Cardiomyocytes. CIRCULATION, 138. -
Microvesicles Rescue Cardiomyocytes From Doxorubicin Injury in a Patient Specific Model of Anthracycline Induced Cardiomyopathy
O'Brien, C. G., Shi, L., Santoso, M. R., Jung, J.-H., Vaskova, E., Ikeda, G., … Yang, P. C. (2018). Microvesicles Rescue Cardiomyocytes From Doxorubicin Injury in a Patient Specific Model of Anthracycline Induced Cardiomyopathy. CIRCULATION, 138. -
A Phase I Study of Allogeneic Mesenchymal Stem Cell Therapy in Patients with Heart Failure Secondary to Anthracycline-induced Cardiomyopathy: The Cctrn Stem Cell Injection in Cancer Survivors (Seneca) Trial
Bolli, R., Perin, E. C., Willerson, J. T., Yang, P. C., Traverse, J. H., Henry, T. D., … Simari, R. D. (2020). A Phase I Study of Allogeneic Mesenchymal Stem Cell Therapy in Patients with Heart Failure Secondary to Anthracycline-induced Cardiomyopathy: The Cctrn Stem Cell Injection in Cancer Survivors (Seneca) Trial. JOURNAL OF CARDIAC FAILURE, 26(10), S97. -
Precise Measurement of Physical Activities and High-Impact Motion: Feasibility of Smart Activity Sensor System
Liu, H.-P., Chuang, Y.-M., Liu, C.-H., Yang, P. C., & Fuh, C.-S. (2021). Precise Measurement of Physical Activities and High-Impact Motion: Feasibility of Smart Activity Sensor System. IEEE SENSORS JOURNAL, 21(1), 568–80. -
Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients: The CCTRN SENECA Trial.
Bolli, R., Perin, E. C., Willerson, J. T., Yang, P. C., Traverse, J. H., Henry, T. D., … Simari, R. D. (2020). Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients: The CCTRN SENECA Trial. JACC. CardioOncology, 2(4), 581–95. -
Comparative analysis on the anti-inflammatory/immune effect of mesenchymal stem cell therapy for the treatment of pulmonary arterial hypertension.
Oh, S., Jang, A. Y., Chae, S., Choi, S., Moon, J., Kim, M., … Chung, W.-J. J. (2021). Comparative analysis on the anti-inflammatory/immune effect of mesenchymal stem cell therapy for the treatment of pulmonary arterial hypertension. Scientific Reports, 11(1), 2012. -
Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium.
Ikeda, G., Santoso, M. R., Tada, Y., Li, A. M., Vaskova, E., Jung, J.-H. H., … Yang, P. C. (2021). Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium. Journal of the American College of Cardiology, 77(8), 1073–88. -
miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury.
Jung, J.-H. H., Ikeda, G., Tada, Y., von Bornstädt, D., Santoso, M. R., Wahlquist, C., … Yang, P. C. (2021). miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury. Basic Research in Cardiology, 116(1), 19. -
A Phase II Study of Autologous Mesenchymal Stromal Cells and c-kit Positive Cardiac Cells, Alone or in Combination, in Patients with Ischemic Heart Failure: The CCTRN CONCERT-HF Trial.
Bolli, R., Mitrani, R. D., Hare, J. M., Pepine, C. J., Perin, E. C., Willerson, J. T., … Simari, R. D. (2021). A Phase II Study of Autologous Mesenchymal Stromal Cells and c-kit Positive Cardiac Cells, Alone or in Combination, in Patients with Ischemic Heart Failure: The CCTRN CONCERT-HF Trial. European Journal of Heart Failure. -
EXOSOMES FROM HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES (ICMS) AND MESENCHYMAL STEM CELLS (MSCS) RECOVER HEART FUNCTION IN PORCINE ACUTE MYOCARDIAL INFARCTION (MI) MODEL
Bayardo, N., O'Brien, C., Vaskova, E., Lyons, J., Tada, Y., & Yang, P. (2021). EXOSOMES FROM HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES (ICMS) AND MESENCHYMAL STEM CELLS (MSCS) RECOVER HEART FUNCTION IN PORCINE ACUTE MYOCARDIAL INFARCTION (MI) MODEL. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. ELSEVIER SCIENCE INC. -
MIR-20B AND-92A ENHANCES CARDIOMYOCYTE CELL CYCLE RE-ENTRY AND PROLIFERATION IN THE ISCHEMIC MYOCARDIUM
Jung, J. H., Ikeda, G., Tada, Y., & Yang, P. (2021). MIR-20B AND-92A ENHANCES CARDIOMYOCYTE CELL CYCLE RE-ENTRY AND PROLIFERATION IN THE ISCHEMIC MYOCARDIUM. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. ELSEVIER SCIENCE INC. -
Recommendations for Nomenclature and Definition Of Cell Products Intended for Human Cardiovascular Use.
Taylor, D. A., Chacon-Alberty, L., Sampaio, L. C., Del Hierro, M. G., Perin, E. C., Mesquita, F. C., … Bolli, R. (2021). Recommendations for Nomenclature and Definition Of Cell Products Intended for Human Cardiovascular Use. Cardiovascular Research. -
Peripheral Blood Biomarkers Associated With Improved Functional Outcome in Patients With Chronic Left Ventricular Dysfunction: A Biorepository Evaluation of the FOCUS-CCTRN Trial.
Chacon Alberty, L., Perin, E. C., Willerson, J. T., Gahremanpour, A., Bolli, R., Yang, P. C., … Taylor, D. A. (2021). Peripheral Blood Biomarkers Associated With Improved Functional Outcome in Patients With Chronic Left Ventricular Dysfunction: A Biorepository Evaluation of the FOCUS-CCTRN Trial. Frontiers in Cardiovascular Medicine, 8, 698088. -
Dual Contrast Manganese-Enhanced MRI and Gadolinium Delayed-Enhanced MRI Detect Heterogenous Myocardial Viability in Ischemic Cardiomyopathy
Tada, Y., Santoso, M. R., Heidary, S., Sano, H., Tachibana, A., Matsuura, Y., … Yang, P. C. (2021). Dual Contrast Manganese-Enhanced MRI and Gadolinium Delayed-Enhanced MRI Detect Heterogenous Myocardial Viability in Ischemic Cardiomyopathy. JACC-CARDIOVASCULAR IMAGING, 14(7), 1474–1476. -
Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial.
O'Brien, C. G., Ozen, M. O., Ikeda, G., Vaskova, E., Jung, J. H., Bayardo, N., … Yang, P. C. (2021). Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial. JACC. CardioOncology, 3(3), 428–440. -
Therapeutic Applications of Extracellular Vesicles for Myocardial Repair.
Liu, C., Bayado, N., He, D., Li, J., Chen, H., Li, L., … Yang, P. C. (1800). Therapeutic Applications of Extracellular Vesicles for Myocardial Repair. Frontiers in Cardiovascular Medicine, 8, 758050. -
Stem Cell and Exosome Therapy in Pulmonary Hypertension.
Oh, S., Jung, J.-H., Ahn, K.-J., Jang, A. Y., Byun, K., Yang, P. C., & Chung, W.-J. (2022). Stem Cell and Exosome Therapy in Pulmonary Hypertension. Korean Circulation Journal, 52(2), 110–122. -
Regenerating Endothelium and Restoring Microvascular Endothelial Function.
Hare, J. M., & Yang, P. (2022). Regenerating Endothelium and Restoring Microvascular Endothelial Function. JACC. Cardiovascular Imaging, 15(5), 825–827. -
Spinning-enabled wireless amphibious origami millirobot.
Ze, Q., Wu, S., Dai, J., Leanza, S., Ikeda, G., Yang, P. C., … Zhao, R. R. (2022). Spinning-enabled wireless amphibious origami millirobot. Nature Communications, 13(1), 3118. -
Angiogenic stem cell delivery platform to augment post-infarction neovasculature and reverse ventricular remodeling.
Shin, H. S., Thakore, A., Tada, Y., Pedroza, A. J., Ikeda, G., Chen, I. Y., … Shudo, Y. (2022). Angiogenic stem cell delivery platform to augment post-infarction neovasculature and reverse ventricular remodeling. Scientific Reports, 12(1), 17605. -
High-resolution, respiratory-resolved coronary MRA using a Phyllotaxis-reordered variable-density 3D cones trajectory.
Koundinyan, S. P., Baron, C. A., Malavé, M. O., Ong, F., Addy, N. O., Cheng, J. Y., … Nishimura, D. G. (2023). High-resolution, respiratory-resolved coronary MRA using a Phyllotaxis-reordered variable-density 3D cones trajectory. Magnetic Resonance Imaging. -
Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis.
Yu, L., Liang, Y., Zhang, M., Yang, P. C., Hinek, A., & Mao, S. (2023). Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis. Communications Biology, 6(1), 133. -
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases.
Li, G., Chen, T., Dahlman, J., Eniola-Adefeso, L., Ghiran, I. C., Kurre, P., … Sundd, P. (2023). Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases. Journal of Extracellular Vesicles, 12(2), e12305. -
Microvascular Obstruction Identifies a Subgroup of Patients Who Benefit from Stem Cell Therapy Following ST-Elevation Myocardial Infarction.
Davidson, S. J., Roncalli, J., Surder, D., Corti, R., Chugh, A. R., Yang, P. C., … Traverse, J. H. (2023). Microvascular Obstruction Identifies a Subgroup of Patients Who Benefit from Stem Cell Therapy Following ST-Elevation Myocardial Infarction. American Heart Journal. -
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic.
Bonilla, H., Quach, T. C., Tiwari, A., Bonilla, A. E., Miglis, M., Yang, P. C., … Geng, L. C. (2023). Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic. Frontiers in Neurology, 14, 1090747. -
Anti-breast cancer-induced cardiomyopathy: Mechanisms and future directions.
Liu, C., Chen, H., Guo, S., Liu, Q., Chen, Z., Huang, H., … Wang, L. (2023). Anti-breast cancer-induced cardiomyopathy: Mechanisms and future directions. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 166, 115373. -
Sex Influences the Safety and Therapeutic Efficacy of Cardiac Nanomedicine Technologies.
Lin, Z., Jiwani, Z., Serpooshan, V., Aghaverdi, H., Yang, P. C., Aguirre, A., … Mahmoudi, M. (2023). Sex Influences the Safety and Therapeutic Efficacy of Cardiac Nanomedicine Technologies. Small (Weinheim an Der Bergstrasse, Germany), e2305940. -
New Alcohol Sensitivity in Patients With Post-acute Sequelae of SARS-CoV-2 (PASC): A Case Series.
Eastin, E. F., Tiwari, A., Quach, T. C., Bonilla, H. F., Miglis, M. G., Yang, P. C., & Geng, L. N. (2023). New Alcohol Sensitivity in Patients With Post-acute Sequelae of SARS-CoV-2 (PASC): A Case Series. Cureus, 15(12), e51286. -
Cloud-Based Machine Learning Platform to Predict Clinical Outcomes at Home for Patients With Cardiovascular Conditions Discharged From Hospital: Clinical Trial.
Yang, P. C., Jha, A., Xu, W., Song, Z., Jamp, P., & Teuteberg, J. J. (2024). Cloud-Based Machine Learning Platform to Predict Clinical Outcomes at Home for Patients With Cardiovascular Conditions Discharged From Hospital: Clinical Trial. JMIR Cardio, 8, e45130.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- Efficacy of EVP 1001-1 (SeeMore) in the Assessment of Myocardial Viability in Patients With Cardiovascular Disease »
- Study of Dutogliptin in Combination With Filgrastim in Post-Myocardial Infarction »
- Stem Cell Injection in Cancer Survivors »
- Administration of Allogeneic-MSC in Patients With Non-Ischemic Dilated Cardiomyopathy »
Practice Locations
General Cardiology Stanford, CA
Stanford, CAGeneral Cardiology
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Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Stanford Echocardiography and Vascular Imaging Center Stanford, CA
Stanford, CAStanford Echocardiography and Vascular Imaging Center
300 Pasteur Drive, 3rd Floor, B36
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »General Cardiology at Boswell Building Stanford, CA
Stanford, CAGeneral Cardiology at Boswell Building
300 Pasteur Drive, 2nd Floor, Room A260
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Patient Reviews
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Referring Physicians
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Stanford Health Care provides comprehensive services to refer and track patients, as well as the latest information and news for physicians and office staff. For help with all referral needs and questions, visit Referral Information.
You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
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