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Intracellular energy failure does not underlie hyperthermic spreading depressions in immature rat hippocampal slice
Intracellular energy failure does not underlie hyperthermic spreading depressions in immature rat hippocampal slice BRAIN RESEARCH Wu, H., Takeo, T., Wakui, M., Ellsworth, K., Fisher, R. S. 2003; 987 (2): 240-243Abstract
Hyperthermic spreading depression (HSD) in immature rat hippocampal slices is mediated by Na+/K(+)-ATPase failure. Here, we test whether depleting intracellular ATP serves as a possible mechanism for HSD genesis. Results indicate that (1) pre-incubation with 3 mM creatine for 3 h failed to prevent hyperthermic spreading depression occurrence; and (2) intracellular ATP concentration doubled during experimental hyperthermia. This study suggests that HSD is not be mediated by depletion of intracellular ATP during hyperthermia.
View details for DOI 10.1016/S0006-8993(03)03355-9
View details for Web of Science ID 000185945900013
View details for PubMedID 14499969