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Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions.
Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions. Metabolism Shen, W., Hu, J., Hu, Z., Kraemer, F. B., Azhar, S. 2014; 63 (7): 875-886Abstract
Scavenger receptor class B type I (SR-BI), is a physiologically relevant HDL receptor that mediates selective uptake of lipoprotein (HDL)-derived cholesteryl ester (CE) in vitro and in vivo. Mammalian SR-BI is a 509-amino acid, ~82 kDa glycoprotein that contains N- and C-terminal cytoplasmic domains, two-transmembrane domains, as well as a large extracellular domain containing 5-6 cysteine residues and multiple sites for N-linked glycosylation. The size and structural characteristics of SR-BI, however, vary considerably among lower vertebrates and insects. Recently, significant progress has been made in understanding the molecular mechanisms involved in the posttranscriptional/posttranslational regulation of SR-BI in a tissue specific manner. The purpose of this review is to summarize the current body of knowledge about the events and molecules connected with the posttranscriptional/posttranslational regulation of SR-BI and to update the molecular and functional characteristics of the insect SR-BI orthologs.
View details for DOI 10.1016/j.metabol.2014.03.011
View details for PubMedID 24854385