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FLUOXETINE AND DESIPRAMINE IN MAJOR DEPRESSIVE DISORDER
FLUOXETINE AND DESIPRAMINE IN MAJOR DEPRESSIVE DISORDER JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY Bowden, C. L., Schatzberg, A. F., Rosenbaum, A., CONTRERAS, S. A., Samson, J. A., DESSAIN, E., Sayler, M. 1993; 13 (5): 305-310Abstract
The efficacy and safety of fluoxetine and desipramine were compared in a 6-week double-blind, parallel group study of patients with major depression. Twenty-five were studied while hospitalized for treatment, and 33 were studied as outpatients. Improvement on the Hamilton Rating Scale for Depression was significant for both treatments from week 1 through the end of the study and did not differ between the two treatments at any week. Overall, 64% of fluoxetine-treated patients and 68% of desipramine-treated patients had at least a 50% reduction in Hamilton Depression score. We assessed whether improvement relatively early in treatment was predictive of categorical response at 6 weeks. Among fluoxetine-treated patients, but not desipramine-treated patients, the week 3 change in the Hamilton Depression mood item was significantly predictive of the response at 6 weeks. Patients treated with fluoxetine had significantly fewer side effects than those treated with desipramine. Desipramine, but not fluoxetine, caused a persistent increase in heart rate. The results suggest that early signs of response to fluoxetine are not dependent on achieving steady-state levels of the drug.
View details for Web of Science ID A1993LZ73700002
View details for PubMedID 8227488