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Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016
Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016 JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK Provenzale, D., Gupta, S., Ahnen, D. J., Bray, T., Cannon, J. A., Cooper, G., David, D. S., Early, D. S., Erwin, D., Ford, J. M., Giardiello, F. M., Grady, W., Halverson, A. L., Hamilton, S. R., Hampel, H., Ismail, M. K., Klapman, J. B., Larson, D. W., Lazenby, A. J., Lynch, P. M., Mayer, R. J., Ness, R. M., Regenbogen, S. E., Samadder, N. J., Shike, M., Steinbach, G., Weinberg, D., Dwyer, M., Darlow, S. 2016; 14 (8): 1010-1030Abstract
This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.
View details for Web of Science ID 000380818400011