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Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics. Drug discovery today Li, K., Nejadnik, H., Daldrup-Link, H. E. 2017

Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI[SB1] . First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices. This review provides an overview of recently developed polymer-coated multifunctional SPIO nanoparticles for cancer theranostics and discusses current challenges and future perspectives.

View details for DOI 10.1016/j.drudis.2017.04.008

View details for PubMedID 28454771