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The use of a sum of inverse Gaussian functions to describe the absorption profile of drugs exhibiting complex absorption
The use of a sum of inverse Gaussian functions to describe the absorption profile of drugs exhibiting complex absorption PHARMACEUTICAL RESEARCH Csajka, C., Drover, D., Verotta, D. 2005; 22 (8): 1227-1235Abstract
The aim of this study was to evaluate the utility of a parametric deconvolution method using a sum of inverse Gaussian functions (IG) to characterize the absorption and concentrations vs. time profile of drugs exhibiting complex absorption.For a linear time-invariant system the response, Y(t), following an arbitrary input function I(t), is the convolution of I(t) with the disposition function, H(t), of the system: [Formula: see text]. The method proposed uses a sum of n inverse Gaussian functions to characterize I(t). The approach was compared with a standard nonparametric method using linear splines. Data were provided from previously published studies on two drugs (hydromorphone and veralipride) showing complex absorption and analyzed with NONMEM.A satisfactory fit for hydromorphone and veralipride data following oral administration was achieved by fitting a sum of two or three IG functions. The predictions of the input functions were very similar to those using linear splines.The use of a sum of IG as opposed to nonparametric functions, such as splines, offers a simpler implementation, a more intuitive interpretation of the results, a built-in extrapolation, and an easier implementation in a population context. Disadvantages are an apparent greater sensitivity to initial value estimates (when used with NONMEM).
View details for DOI 10.1007/s11095-005-5266-8
View details for Web of Science ID 000230990900003
View details for PubMedID 16078132