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MR imaging of therapy-induced changes of bone marrow EUROPEAN RADIOLOGY Daldrup-Link, H. E., Henning, T., Link, T. M. 2007; 17 (3): 743-761

Abstract

MR imaging of bone marrow infiltration by hematologic malignancies provides non-invasive assays of bone marrow cellularity and vascularity to supplement the information provided by bone marrow biopsies. This article will review the MR imaging findings of bone marrow infiltration by hematologic malignancies with special focus on treatment effects. MR imaging findings of the bone marrow after radiation therapy and chemotherapy will be described. In addition, changes in bone marrow microcirculation and metabolism after anti-angiogenesis treatment will be reviewed. Finally, new specific imaging techniques for the depiction of regulatory events that control blood vessel growth and cell proliferation will be discussed. Future developments are directed to yield comprehensive information about bone marrow structure, function and microenvironment.

View details for DOI 10.1007/s00330-006-0404-1

View details for Web of Science ID 000244192100018

View details for PubMedID 17021706

View details for PubMedCentralID PMC1797072