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Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK Singh, J., Moore, W., Fattah, F., Jiang, X., Zheng, J., Kurian, P., Beg, M. S., Khan, S. A. 2019; 41 (1): E11-E15

Abstract

Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient.Homemade AgNP solution is manufactured using online instructions by a 78-year old male. He started consuming AgNP while on hospice after he developed nasal cavity squamous cell cancer metastatic to liver and lung.Electron microscopy of AgNP solution revealed bimodal nanoparticle size distribution: 3 and 12?nm. Inductively coupled plasma mass spectrometry showed basal silver ion concentrations of 32?ng/g, rising to 46?ng/g 1 hour after ingesting 60?mL of AgNP solution. Urine showed no AgNP. No toxicities were observed and he had complete radiographic resolution of his cancer. He remains without evidence of cancer 18?months later.AgNP ingestion was associated with sustained radiographic resolution of cancer. Further testing of AgNP should be done to confirm its efficacy in head and neck cancer.

View details for DOI 10.1002/hed.25492

View details for Web of Science ID 000456174700003

View details for PubMedID 30537286