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Causal Cortical and Thalamic Connections in the Human Brain.
Causal Cortical and Thalamic Connections in the Human Brain. Research square Parvizi, J., Lyu, D., Stieger, J., Lusk, Z., Buch, V. 2024Abstract
The brain's functional architecture is intricately shaped by causal connections between its cortical and subcortical structures. Here, we studied 27 participants with 4864 electrodes implanted across the anterior, mediodorsal, and pulvinar thalamic regions, and the cortex. Using data from electrical stimulation procedures and a data-driven approach informed by neurophysiological standards, we dissociated three unique spectral patterns generated by the perturbation of a given brain area. Among these, a novel waveform emerged, marked by delayed-onset slow oscillations in both ipsilateral and contralateral cortices following thalamic stimulations, suggesting a mechanism by which a thalamic site can influence bilateral cortical activity. Moreover, cortical stimulations evoked earlier signals in the thalamus than in other connected cortical areas suggesting that the thalamus receives a copy of signals before they are exchanged across the cortex. Our causal connectivity data can be used to inform biologically-inspired computational models of the functional architecture of the brain.
View details for DOI 10.21203/rs.3.rs-4366486/v1
View details for PubMedID 38853954
View details for PubMedCentralID PMC11160924