Personal Genomics for Preventive Cardiology
Trial ID or NCT#
The purpose of this study is to see if providing information to a person on their inherited (genetic) risk of cardiovascular disease (CVD) helps to motivate that person to change their diet, lifestyle or medication regimen to alter their risk.
A Pilot Randomized Trial of Personal Genomics for Preventive Cardiology
- - Adults age > 18 - Patient seeking cardiovascular risk evaluation - At intermediate (6-20%) or high risk (> 20%) over 10 years of CAD as defined by Framingham 10 year risk score AND/OR at > 20% risk of CAD over 30 years using the Framingham 30 year risk calculator - The genetic risk factors have been evaluated predominantly in white/European subjects. However, there is considerable overlap in the genetic architecture of South Asians and Hispanic/Latino populations. Therefore, we will limit our initial studies to these three race/ethnicity groups.
- - History of myocardial infarction, angina, stroke, peripheral arterial disease, PCI, or CABG - Already on lipid lowering therapy - Anticipated survival <1 year (e.g. metastatic cancer) - Serious conditions that would limit ability to adhere to recommendations (inability to take statins, exercise) - Already had genetic testing - Concurrent enrollment in another clinical trial - Pregnant or breastfeeding
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