Biography
Dr. Alexander specializes in the management of advanced heart failure and transplant cases, seeing a wide range of patients. He also has an active research laboratory, studying various forms of heart failure.
Dr. Alexander has expertise in diagnosing and treating transthyretin cardiac amyloidosis, a critical yet underdiagnosed cause of heart failure among African Americans and the elderly. He is conducting extensive research to enhance our understanding of this condition, with grant support from the National Institutes of Health and American Heart Association, among other sources.
Professional Summary
Education & Certifications
- Fellowship: Stanford University Advanced Heart Failure and Transplant Fellowship (2019) CA
- Board Certification: American Board of Internal Medicine, Advanced Heart Failure and Transplant Cardiology (2020)
- Board Certification, American Board of Internal Medicine, Advanced Heart Failure and Transplant Cardiology (2020)
- Board Certification, American Board of Internal Medicine, Cardiovascular Disease (2017)
- Board Certification, American Board of Internal Medicine, Internal Medicine (2014)
- Fellowship, Stanford Health Care, Advanced Heart Failure and Transplant Cardiology (2019)
- Fellowship, Brigham and Women's Hospital, Cardiovascular Medicine (2017)
- Residency, Johns Hopkins Hospital, Internal Medicine (2014)
- M.D., University of Pennsylvania (2011)
- B.S., Yale University, Molecular Biophysics and Biochemistry (2006)
Honors & Awards
- ASPIRE Transthyretin Amyloidosis Competitive Research Grant, Pfizer (2017)
- Carl Storm Underrepresented Minority Fellowship, Gordon Research Conference (2017)
- Fellow, American College of Cardiology (2019-)
- Fellow, Heart Failure Society of America (2021-)
- Gertrude M and Ezra M. Eisen Prize for Cardiovascular Research, University of Pennsylvania (2011)
- Harold Amos Medical Faculty Development Program Award, American Heart Association (2019-2023)
- Loan Repayment Program Award, National Institutes of Health (2017-2019, 2019-2020)
- Presidential Travel Award, International Society of Amyloidosis (2018)
- Sarnoff Cardiovascular Research Fellowship, Sarnoff Cardiovascular Foundation (2009-2011)
- Stanford KL2 Mentored Career Development Program Award, National Institutes of Health (2020-2022)
- Thomas W. Smith Fellowship in Heart Failure, Brigham and Women’s Hospital (2017)
Memberships
- Member, Alumni Committee, Sarnoff Cardiovascular Research Foundation (2017 - 2019)
- Co-Chair, Diversity and Inclusion Committee, California Chapter, American College of Cardiology (2018 - 2020)
- Editorial Board, Circulation Research (2019 - Present)
- Member, BCVS Early Career Committee, American Heart Association (2020 - Present)
- Member, Scientific Advisory and Coordinating Committee, American Heart Association (2021 - Present)
Publications
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True, true unrelated? Coexistence of Waldenstrom's macroglobulinemia and cardiac transthyretin Amyloidosis.
Singh, A., Geller, H. I., Alexander, K. M., Padera, R. F., Mitchell, R. N., Dorbala, S., … Falk, R. H. (2018). True, true unrelated? Coexistence of Waldenstrom's macroglobulinemia and cardiac transthyretin Amyloidosis. Haematologica. -
Novel pharmacotherapies for cardiac amyloidosis.
Alexander, K. M., Singh, A., & Falk, R. H. (2017). Novel pharmacotherapies for cardiac amyloidosis. Pharmacology & Therapeutics, 180, 129–138. -
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Association Between Ruptured Distal Biceps Tendon and Wild-Type Transthyretin Cardiac Amyloidosis.
Geller, H. I., Singh, A., Alexander, K. M., Mirto, T. M., & Falk, R. H. (2017). Association Between Ruptured Distal Biceps Tendon and Wild-Type Transthyretin Cardiac Amyloidosis. JAMA, 318(10), 962–963. -
Geographic Disparities in Reported US Amyloidosis Mortality From 1979 to 2015: Potential Underdetection of Cardiac Amyloidosis.
Alexander, K. M., Orav, J., Singh, A., Jacob, S. A., Menon, A., Padera, R. F., … Dorbala, S. (2018). Geographic Disparities in Reported US Amyloidosis Mortality From 1979 to 2015: Potential Underdetection of Cardiac Amyloidosis. JAMA Cardiology. -
Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial.
Sharma, K., Vaishnav, J., Kalathiya, R., Hu, J.-R. R., Miller, J., Shah, N., … Russell, S. D. (2018). Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial. JACC. Heart Failure. -
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Mortality from Heart Failure and Dementia in the United States: CDC WONDER 1999-2016.
Vuong, J. T., Jacob, S. A., Alexander, K. M., Singh, A., Liao, R., Desai, A. S., & Dorbala, S. (2018). Mortality from Heart Failure and Dementia in the United States: CDC WONDER 1999-2016. Journal of Cardiac Failure. -
Trends and causes of hospitalizations in patients with amyloidosis.
Patil, N., Arora, S., Qamar, A., Strassle, P. D., Alexander, K. M., Fatima, A., … Pandey, A. (2019). Trends and causes of hospitalizations in patients with amyloidosis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis, 1–2. -
Emerging Therapies for Transthyretin Cardiac Amyloidosis.
Alexander, K. M., Evangelisti, A., & Witteles, R. M. (2019). Emerging Therapies for Transthyretin Cardiac Amyloidosis. Current Treatment Options in Cardiovascular Medicine, 21(8), 40. -
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Harnessing Cardiac Regeneration as a Potential Therapeutic Strategy for AL Cardiac Amyloidosis.
Joshi, S., Evangelisti, A., Liao, R., & Alexander, K. M. (2020). Harnessing Cardiac Regeneration as a Potential Therapeutic Strategy for AL Cardiac Amyloidosis. Current Cardiology Reports, 22(1), 1. -
Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction.
Schimmel, K., Jung, M., Foinquinos, A., San José, G., Beaumont, J., Bock, K., … Thum, T. (2020). Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation. -
Bone Scintigraphy Imaging for Transthyretin Cardiac Amyloidosis: Still Much to Learn.
Alexander, K. M., & Witteles, R. M. (2020). Bone Scintigraphy Imaging for Transthyretin Cardiac Amyloidosis: Still Much to Learn. JACC. Cardiovascular Imaging. -
Management of Cardiac Amyloidosis: Do's and Don'ts.
Alexander, K. M., & Witteles, R. M. (2019). Management of Cardiac Amyloidosis: Do's and Don'ts. The Canadian Journal of Cardiology. -
Gene Signatures to Distinguish Amyloid Cardiomyopathy Risk in Multiple Myeloma Patients
Jha, A., Morgado, I., Lee, D. J., Alexander, K., Tsai, C.-Y., Schimmel, K., … Dangwal, S. (2019). Gene Signatures to Distinguish Amyloid Cardiomyopathy Risk in Multiple Myeloma Patients. CIRCULATION RESEARCH, 125. -
Prenatal Exposure of Cigarette Smoke Impacts Cardiac Regeneration
Schimmel, K., Morgado, I., Tsai, C.-Y., Evangelisti, A., Fisch, S., Ngoy, S., … Liao, R. (2019). Prenatal Exposure of Cigarette Smoke Impacts Cardiac Regeneration. CIRCULATION RESEARCH, 125. -
High-Frequency Ultrasound Echocardiography to Assess Zebrafish Cardiac Function.
Evangelisti, A., Schimmel, K., Joshi, S., Shah, K., Fisch, S., Alexander, K. M., … Morgado, I. (2020). High-Frequency Ultrasound Echocardiography to Assess Zebrafish Cardiac Function. Journal of Visualized Experiments : JoVE, (157). -
Outcomes in Patients With Cardiac Amyloidosis Undergoing Heart Transplantation.
Barrett, C. D., Alexander, K. M., Zhao, H., Haddad, F., Cheng, P., Liao, R., … Witteles, R. M. (2020). Outcomes in Patients With Cardiac Amyloidosis Undergoing Heart Transplantation. JACC. Heart Failure. -
Myocarditis and Pericarditis
Alexander, K. (2016). Myocarditis and Pericarditis. Infectious Diseases Emergencies (pp. 103–106). Oxford University Press. -
Pulling at the heart: COVID-19, race/ethnicity and ongoing disparities.
Chin-Hong, P., Alexander, K. M., Haynes, N., & Albert, M. A. (2020). Pulling at the heart: COVID-19, race/ethnicity and ongoing disparities. Nature Reviews. Cardiology. -
Serum high-density lipoprotein cholesterol serves as a prognostic marker for light-chain cardiac amyloidosis.
Yang, T., Wan, K., Song, R., Guo, X., Xu, Y., Wang, J., … Chen, Y. (2020). Serum high-density lipoprotein cholesterol serves as a prognostic marker for light-chain cardiac amyloidosis. International Journal of Cardiology. -
Recipe for Success in Transthyretin Cardiomyopathy: Monoclonal Protein Rule Out, SPECT Imaging, and Genetic Testing.
Alexander, K. M., & Masri, A. (2020). Recipe for Success in Transthyretin Cardiomyopathy: Monoclonal Protein Rule Out, SPECT Imaging, and Genetic Testing. JACC. Cardiovascular Imaging. -
Challenges and the innovations in the care of advanced heart failure patients during COVID-19.
Yehya, A., Shah, K. S., Mitter, S. S., Ibrahim, N. E., Sperry, B., Shah, M., … Kittleson, M. M. (2021). Challenges and the innovations in the care of advanced heart failure patients during COVID-19. Heart Failure Reviews. -
Advances in the Diagnosis and Management of Transthyretin Amyloid Cardiomyopathy
Spencer-Bonilla, G., Alexander, K. M., & Witteles, R. M. (2020). Advances in the Diagnosis and Management of Transthyretin Amyloid Cardiomyopathy. Curr Treat Options Cardio Med, 22(45). -
MicroRNA-21 regulates right ventricular remodeling secondary to pulmonary arterial pressure overload.
Chang, W.-T., Fisch, S., Dangwal, S., Mohebali, J., Fiedler, A. G., Chen, M., … Liao, R. (2021). MicroRNA-21 regulates right ventricular remodeling secondary to pulmonary arterial pressure overload. Journal of Molecular and Cellular Cardiology. -
Decoding the Nanoenvironment in Cardiac Amyloidosis Through Proteomics
Alexander, K. M., Jha, A., & Liao, R. (2020). Decoding the Nanoenvironment in Cardiac Amyloidosis Through Proteomics. JACC: CARDIOONCOLOGY, 2(4), 644–46. -
Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support.
Birati, E. Y., Najjar, S. S., Tedford, R. J., Houston, B. A., Shore, S., Vorovich, E., … Genuardi, M. V. (2021). Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support. Circulation. Heart Failure, CIRCHEARTFAILURE120007957. -
Transthyretin Cardiac Amyloidosis in the Elderly-Tip of a Heart Failure Iceberg?
Alexander, K. M., & Dorbala, S. (2021). Transthyretin Cardiac Amyloidosis in the Elderly-Tip of a Heart Failure Iceberg? JAMA Cardiology. -
Coronavirus disease 2019 in heart transplant recipients: Risk factors, immunosuppression, and outcomes.
Genuardi, M. V., Moss, N., Najjar, S. S., Houston, B. A., Shore, S., Vorovich, E., … Birati, E. Y. (2021). Coronavirus disease 2019 in heart transplant recipients: Risk factors, immunosuppression, and outcomes. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. -
Prevalence and Outcomes of p.Val142Ile TTR Amyloidosis Cardiomyopathy: A Systematic Review.
Chandrashekar, P., Alhuneafat, L., Mannello, M., Al-Rashdan, L., Kim, M. M., Dungu, J., … Masri, A. (2021). Prevalence and Outcomes of p.Val142Ile TTR Amyloidosis Cardiomyopathy: A Systematic Review. Circulation. Genomic and Precision Medicine, CIRCGEN121003356. -
Mistaken Identity: Using Bone Scintigraphy to Diagnose Cardiac Amyloidosis in Patients With a Monoclonal Gammopathy
Nguyen, A. T., & Alexander, K. M. (2021). Mistaken Identity: Using Bone Scintigraphy to Diagnose Cardiac Amyloidosis in Patients With a Monoclonal Gammopathy. JACC: CardioOncology, 3(4), 594–597. -
Future Perspectives of Cardiovascular Biomarker Utilization in Cancer Survivors: A Scientific Statement From the American Heart Association.
Zaha, V. G., Hayek, S. S., Alexander, K. M., Beckie, T. M., Hundley, W. G., Kondapalli, L., … Shah, S. H. (2021). Future Perspectives of Cardiovascular Biomarker Utilization in Cancer Survivors: A Scientific Statement From the American Heart Association. Circulation, CIR0000000000001032. -
Electrocardiogram Characteristics and Prognostic Value in Light-Chain Amyloidosis: A Comparison With Cardiac Magnetic Resonance Imaging.
Guo, X., Chen, Z., Wan, K., Song, R., Yang, T., Xu, Y., … Chen, Y. (1800). Electrocardiogram Characteristics and Prognostic Value in Light-Chain Amyloidosis: A Comparison With Cardiac Magnetic Resonance Imaging. Frontiers in Cardiovascular Medicine, 8, 751422. -
Proteotoxicity and Autophagy in Neurodegenerative and Cardiovascular Diseases
Alexander, K. M., Morgado, I., & Liao, R. (2022). Proteotoxicity and Autophagy in Neurodegenerative and Cardiovascular Diseases. Biochemistry of Apoptosis and Autophagy (pp. 219–237). Springer. -
High-Throughput Precision Phenotyping of Left Ventricular Hypertrophy With Cardiovascular Deep Learning.
Duffy, G., Cheng, P. P., Yuan, N., He, B., Kwan, A. C., Shun-Shin, M. J., … Ouyang, D. (2022). High-Throughput Precision Phenotyping of Left Ventricular Hypertrophy With Cardiovascular Deep Learning. JAMA Cardiology. -
Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis.
Spencer-Bonilla, G., Njoroge, J. N., Pearson, K., Witteles, R. M., Aras, M. A., & Alexander, K. M. (2021). Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis. Current Cardiovascular Risk Reports, 15(6). -
Cardiac Amyloid Heart Disease in Racial/Ethnic Minorities: Focus on Transthyretin Amyloid Cardiomyopathy
Alexander, K. M., Maurer, M. S., & Fergus, I. V. (2021). Cardiac Amyloid Heart Disease in Racial/Ethnic Minorities: Focus on Transthyretin Amyloid Cardiomyopathy. CARDIOVASCULAR DISEASE IN RACIAL AND ETHNIC MINORITY POPULATIONS, 2 EDITION, 201–215. -
Prevalence, mutational spectrum and clinical implications of clonal hematopoiesis of indeterminate potential in plasma cell dyscrasias.
Testa, S., Kumar, J., Goodell, A. J., Zehnder, J. L., Alexander, K. M., Sidana, S., … Liedtke, M. (2022). Prevalence, mutational spectrum and clinical implications of clonal hematopoiesis of indeterminate potential in plasma cell dyscrasias. Seminars in Oncology. -
Effects of Body Mass Index on Presentation and Outcomes of COVID-19 among Heart Transplant and Left Ventricular Assist Device Patients: A Multi-Institutional Study.
Iyengar, A., Cohen, W., Han, J., Helmers, M., Kelly, J. J., Patrick, W., … Atluri, P. (2023). Effects of Body Mass Index on Presentation and Outcomes of COVID-19 among Heart Transplant and Left Ventricular Assist Device Patients: A Multi-Institutional Study. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 69(1), 43–49. -
Nurturing Diverse Generations of the Medical Workforce for Success With Authenticity: An Association of Black Cardiologists' Roundtable.
Haynes, N. A., Johnson, M., Lewsey, S. C., Alexander, K. M., Anstey, D. E., Dillenburg, T., … Albert, M. A. (2023). Nurturing Diverse Generations of the Medical Workforce for Success With Authenticity: An Association of Black Cardiologists' Roundtable. Circulation. Cardiovascular Quality and Outcomes, e009032. -
Implications of Extra-cardiac Disease in Patient Selection for Heart Transplantation: Considerations in Cardiac Amyloidosis.
Punnoose, L. R., Siddiqi, H., Rosenthal, J., Kittleson, M., Witteles, R., & Alexander, K. (2023). Implications of Extra-cardiac Disease in Patient Selection for Heart Transplantation: Considerations in Cardiac Amyloidosis. Cardiac Failure Review, 9, e01. -
Exploring Race and Sex Differences in Cardiac Sarcoidosis: "Dispare" No More.
Gupta, R., Bermudez, F., Alexander, K. M., & Sheikh, F. H. (2023). Exploring Race and Sex Differences in Cardiac Sarcoidosis: "Dispare" No More. Journal of Cardiac Failure. -
TEMPORARY REMOVAL: Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America.
Bozkurt, B., Ahmad, T., Alexander, K., Baker, W. L., Bosak, K., Breathett, K., … Ziaeian, B. (2023). TEMPORARY REMOVAL: Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America. Journal of Cardiac Failure. -
Almanac: Retrieval-Augmented Language Models for Clinical Medicine.
Zakka, C., Chaurasia, A., Shad, R., Dalal, A. R., Kim, J. L., Moor, M., … Hiesinger, W. (2023). Almanac: Retrieval-Augmented Language Models for Clinical Medicine. Research Square. -
Almanac - Retrieval-Augmented Language Models for Clinical Medicine.
Zakka, C., Shad, R., Chaurasia, A., Dalal, A. R., Kim, J. L., Moor, M., … Hiesinger, W. (2024). Almanac - Retrieval-Augmented Language Models for Clinical Medicine. NEJM AI, 1(2). -
Healthcare Resource Utilization And Disease Burden In Patients With Transthyretin Amyloidosis With Cardiomyopathy: Results From The Amyloidosis Research Consortium Transthyretin Amyloidosis Burden Of Illness Study
Rebello, S., Hsu, K., Berk, J., Alexander, K., Polydefkis, M., Gibbs, S., … Maurer, M. (2024). Healthcare Resource Utilization And Disease Burden In Patients With Transthyretin Amyloidosis With Cardiomyopathy: Results From The Amyloidosis Research Consortium Transthyretin Amyloidosis Burden Of Illness Study. JOURNAL OF CARDIAC FAILURE. CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS. -
Impact Of Micro-education On Physician Knowledge, Competence, And Confidence Related To The Diagnosis And Treatment Of Transthyretin Cardiac Amyloidosis In Underserved Patient Populations
Harris, M., O'Connor, A., Capparelli, C., Dillenburg, T., Gore, C., & Alexander, K. (2024). Impact Of Micro-education On Physician Knowledge, Competence, And Confidence Related To The Diagnosis And Treatment Of Transthyretin Cardiac Amyloidosis In Underserved Patient Populations. JOURNAL OF CARDIAC FAILURE. CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS. -
Defining Disease Progression in ATTR Cardiac Amyloidosis: Keeping It Simple.
Alexander, K. M. (2024). Defining Disease Progression in ATTR Cardiac Amyloidosis: Keeping It Simple. Journal of the American College of Cardiology. -
Outcomes with guideline-directed medical therapy and cardiac implantable electronic device therapies for patients with heart failure with reduced ejection fraction.
Mignone, J. L., Alexander, K. M., Dobbles, M., Eberst, K., Fonarow, G. C., & Ellenbogen, K. A. (2024). Outcomes with guideline-directed medical therapy and cardiac implantable electronic device therapies for patients with heart failure with reduced ejection fraction. Heart Rhythm O2, 5(3), 168–173.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) »
- HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy »
- A Research Study to Look at How a New Medicine Called NNC6019-0001 Works and How Safe it is for People Who Have Heart Disease Due to Transthyretin (TTR) Amyloidosis »
- MitraClip REPAIR MR Study »
Practice Locations
Mechanical Circulatory Support Program Stanford, CA
Stanford, CAMechanical Circulatory Support Program
300 Pasteur Drive, 2nd Floor, Room A260
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Heart Transplant Program Stanford, CA
Stanford, CAHeart Transplant Program
300 Pasteur Drive, 2nd Floor, Room A21
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Heart Failure Clinic at Stanford Stanford, CA
Stanford, CAHeart Failure Clinic at Stanford
300 Pasteur Drive, 2nd Floor, Room A260
Stanford , CA 94305
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