- Alexander Glassman Award, Columbia University School of Physicians and Surgeons (2022)
- Alumni Leadership Award, NYU School of Medicine (2018)
- Anna Monika Prize, Anna Monika Foundation (2013)
- Chair Achievement Award, CME Outfitters (2010)
- David A. Mrazek, MD Memorial Award in Psychiatric Pharmacogenomics, American Psychiatric Association (2019)
- Distinguished Service in Psychiatry Award, American Psychiatric Association (2018)
- Distinguished Service in Psychiatry Award, The American College of Psychiatrists (2005)
- Donald Klein Lifetime Achievement Award, American Society of Clinical Psychopharmacology (2019)
- Edward A. Strecker, MD Award, University of Pennsylvania School of Medicine (2001)
- Elected Member, Institute of Medicine of the National Academy of Sciences (2003)
- Falcone Award, National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD) (2005)
- Forum Award, International Forum on Mood and Anxiety Disorders (IFMAD) (2002)
- Gerald L. Klerman, MD Lifetime Research Award, National Depressive and Manic Depressive Association (NDMDA) (1998)
- Gold Medal, Society of Biological Psychiatry (2015)
- Honoris Causa, Doctor of Humane Letters, Pacific Graduate School of Psychology, Palo Alto University (2008)
- Honoris Causa, Doctor of Medicine, Maimonedes University, Buenos Aires (2013)
- Honoris Causa, Medical Doctor, Mediziniche Universität, Wien (2011)
- Judd Marmor Award for Biopsychosocial Research, American Psychiatric Association (2018)
- Julius Axelrod Mentorship Award, American College of Neuropsychopharmacology (2017)
- Klerman Award, Cornell Medical College (2001)
- Kraepelin Gold Medal, Max Planck Institute of Psychiatry (2014)
- Lifetime Achievement Award, International Society of Psychoneuroendocrinology (2015)
- Menas Gregory Lecture, New York University School of Medicine (2022)
- Meritorius Service Medal, United States Air Force (1974)
- Mood Disorders Research Award, American College of Psychiatrists (2002)
- Professor Honoris Causa de la Facultad de Ciencias Medicas, Universidad Favaloro, Buenos Aires (2015)
- Research Award, American Psychiatric Association (2002)
- Solomon A. Berson Medical Alumni Achievement Award, New York University School of Medicine (2019)