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Wilson Disease Symptoms
What Are the Symptoms of Wilson Disease?
The symptoms of Wilson disease depend on the organs involved. Rusty brown rings around the iris of your eye, called Kayser-Fleischer rings, are the most significant symptom. The copper buildup causes these rings, which affect about half of all people with Wilson disease. Wilson disease may attack your central nervous system, as well as your liver, sometimes at the same time. As a result, you may have a collection of seemingly unrelated symptoms.
Symptoms can appear at any time in life, although they usually start between ages 5 and 35. Liver symptoms tend to appear in late childhood or adolescence, whereas neurological symptoms appear in adulthood.
Liver symptoms include:
- Fatigue
- Fluid in your belly or legs
- Easy bruising
- Swollen liver and spleen
Neurologic symptoms include:
- Changes in behavior
- Stiff muscles
- Tremors, shakes, or motions you can't control
- Slow or repetitive movements
- Loss of muscle tone
- Difficulty swallowing
- Slurred speech
- Poor coordination
- Drooling
- Decreased fine motor abilities
- Psychological changes, such as psychosis, neurosis, or suicidal thoughts
Other miscellaneous symptoms you might experience are:
- Early changes in bone density or joints
- Unhealthy levels of amino acids, proteins, carbohydrates, and uric acid in your urine
- Anemia
- Lower-than-normal levels of platelets or white blood cells