Esophageal Cancer Treatment Planning
Following a diagnosis of esophageal cancer, we work carefully to determine the best treatment options for you and to prepare a treatment plan personalized for your needs. We try to maximize treatment success while minimizing the impact that diagnosis and treatment can have on your life.
WHAT TO KNOW ABOUT ESOPHAGEAL TREATMENT PLANNING
1Getting Started In Your Care
2Getting Your Diagnosis
3Planning Your Treatment
Considering Your Options »
4Undergoing Treatment & Follow-Up
Select your type of treatment below.
Assessment
Evaluating Options
Choosing Treatment
The team evaluates different options for your treatment plan. The treatment recommended for you will primarily be based on:
- The specific type and location of the esophageal cancer
- The stage of the esophageal cancer
- Stage is determined using a variety of testing to evaluate whether the cancer is confined to the esophageal wall only, whether it has spread (metastasized) to the lymph nodes (small glands that filter bacteria, viruses, cancer cells, and other impurities from the body), or if the cancer has spread to other parts of the body
- Markers, such as growth factors, that provide genetic information about the subtype of the cancer are not as commonly used yet for esophageal cancer compared to other cancers, but can be helpful for some patients
About esophageal cancer » - Your age and overall health
Learn more about treatment planning »
We discuss different types of treatment and how to combine them in a sequence that will best treat the cancer.
a. Your doctors may prescribe a treatment plan that combines one or more of the three main types of treatment: surgery, radiation therapy, and drug therapy (medications that travel through the bloodstream to attack cancer anywhere in the body). The combination of treatment types may need to take place in a specific order to best treat your specific condition.
Learn about treatments for esophageal cancer »
b. Your treatment options will also be determined by the stage of your cancer. We can treat all the stages of esophageal cancer, from the earliest to the latest stages.
Choosing your treatment
Your care team will explain the options and the possible treatment sequence. Your doctors will help you make an informed decision about which options may be right for you. Depending on your treatment, a surgeon who specializes in cancer treatment, a medical oncologist, or a radiation oncologist leads your team and remains your main doctor throughout treatment.
The best treatment for one person might not be the best treatment for another. There are three topics to consider when discussing with your doctor what works best for you.
Medical goals
Your care team will recommend treatment options based on your specific diagnosis. Different types of treatment for esophageal cancer have different goals, such as:
- Curing the esophageal cancer so it never comes back
- Slowing or stopping the growth or spread of cancer, if it is not considered curable to preserve quality of life for as long as possible
- Managing symptoms of both from incurable cancer and from the cancer and the treatment for patients undergoing potentially curable therapy
Personal treatment goals
As you and your care team discuss and make decisions about your treatment plan, it helps to think about your goals for treatment. These goals are different for each person. Some patients want to do whatever is necessary to be able to live as long as possible, while others value avoiding discomfort from either cancer or treatment.
It’s important for your loved ones to understand your treatment goals and wishes, so talk to them. You can ask family and friends for emotional support and help with a variety of issues during your care journey.
The effect of treatment on everyday life
Your care team can help you understand how various treatments can help you achieve your goals. Discuss what you want to be able to do, both during treatment and after it is complete. Issues specific to your health include:
- Treatment: How esophageal cancer and treatments will affect you and your ability to continue your everyday activities at work and home
- Side effects and symptoms: How to manage and cope with disease symptoms and treatment side effects
- Balance: Ways to balance aggressive treatment that prolongs survival with side effect management that maintains a good quality of life
Other important issues to consider include:
- Communication: Ways to talk to your family, friends, and others (such as co-workers) about your diagnosis, and how to ask for help
- Emotional well-being: How to manage your own emotions and the emotional impact of your diagnosis on your family and friends
- Relationships: How to maintain relationships with your partner, family, and friends, including intimacy, everyday activities, and responsibilities
- Appearance and body image: Ways to cope with changes that may result from treatment and the cancer itself
- Daily activities: How to take care of yourself, look after your family, and balance work responsibilities while undergoing Esophageal cancer treatment
- Travel and distance: How to manage family and work responsibilities if you are coming to Stanford from outside the Bay Area
The team evaluates different options for your treatment plan. The treatment recommended for you will primarily be based on:
- The specific type and location of the esophageal cancer
- The stage of the esophageal cancer
- Stage is determined using a variety of testing to evaluate whether the cancer is confined to the esophageal wall only, whether it has spread (metastasized) to the lymph nodes (small glands that filter bacteria, viruses, cancer cells, and other impurities from the body), or if the cancer has spread to other parts of the body
- Markers, such as growth factors, that provide genetic information about the subtype of the cancer are not as commonly used yet for esophageal cancer compared to other cancers, but can be helpful for some patients
About esophageal cancer » - Your age and overall health
Learn more about treatment planning »
close Assessment
We discuss different types of treatment and how to combine them in a sequence that will best treat the cancer.
a. Your doctors may prescribe a treatment plan that combines one or more of the three main types of treatment: surgery, radiation therapy, and drug therapy (medications that travel through the bloodstream to attack cancer anywhere in the body). The combination of treatment types may need to take place in a specific order to best treat your specific condition.
Learn about treatments for esophageal cancer »
b. Your treatment options will also be determined by the stage of your cancer. We can treat all the stages of esophageal cancer, from the earliest to the latest stages.
close Evaluating Options
Choosing your treatment
Your care team will explain the options and the possible treatment sequence. Your doctors will help you make an informed decision about which options may be right for you. Depending on your treatment, a surgeon who specializes in cancer treatment, a medical oncologist, or a radiation oncologist leads your team and remains your main doctor throughout treatment.
The best treatment for one person might not be the best treatment for another. There are three topics to consider when discussing with your doctor what works best for you.
Medical goals
Your care team will recommend treatment options based on your specific diagnosis. Different types of treatment for esophageal cancer have different goals, such as:
- Curing the esophageal cancer so it never comes back
- Slowing or stopping the growth or spread of cancer, if it is not considered curable to preserve quality of life for as long as possible
- Managing symptoms of both from incurable cancer and from the cancer and the treatment for patients undergoing potentially curable therapy
Personal treatment goals
As you and your care team discuss and make decisions about your treatment plan, it helps to think about your goals for treatment. These goals are different for each person. Some patients want to do whatever is necessary to be able to live as long as possible, while others value avoiding discomfort from either cancer or treatment.
It’s important for your loved ones to understand your treatment goals and wishes, so talk to them. You can ask family and friends for emotional support and help with a variety of issues during your care journey.
The effect of treatment on everyday life
Your care team can help you understand how various treatments can help you achieve your goals. Discuss what you want to be able to do, both during treatment and after it is complete. Issues specific to your health include:
- Treatment: How esophageal cancer and treatments will affect you and your ability to continue your everyday activities at work and home
- Side effects and symptoms: How to manage and cope with disease symptoms and treatment side effects
- Balance: Ways to balance aggressive treatment that prolongs survival with side effect management that maintains a good quality of life
Other important issues to consider include:
- Communication: Ways to talk to your family, friends, and others (such as co-workers) about your diagnosis, and how to ask for help
- Emotional well-being: How to manage your own emotions and the emotional impact of your diagnosis on your family and friends
- Relationships: How to maintain relationships with your partner, family, and friends, including intimacy, everyday activities, and responsibilities
- Appearance and body image: Ways to cope with changes that may result from treatment and the cancer itself
- Daily activities: How to take care of yourself, look after your family, and balance work responsibilities while undergoing Esophageal cancer treatment
- Travel and distance: How to manage family and work responsibilities if you are coming to Stanford from outside the Bay Area
close Choosing Treatment
Overview:
Every cancer is different, even amongst patients who have similar stages. The best treatment for one person might not be the best treatment for another. Your doctor will help you make an informed decision about which options may be right for you. Your treatment plan may consist of one or any combination of the following:
Surgery
Your care team may recommend surgery to diagnose, stage, or treat cancer:
- Diagnosis: Your doctor may recommend that you have a surgical biopsy, to obtain tissue samples and determine a more precise diagnosis.
- Staging: Surgery can help determine the stage of esophageal cancer with procedures that can evaluate the tumor in the esophagus as well as to evaluate if the cancer has spread anywhere.
- Treatment: Surgically removing the tumor may be part of the best treatment for you. In addition, some surgical procedures such as placing a feeding tube or a stent can help a patient tolerate their therapy
Surgery Resources
Should surgery be part of your care plan, we are here to help guide you through the process.
If surgery provides a good treatment option, you will meet with a surgeon who specializes in espohagal cancer surgery to develop a plan. The most appropriate surgery for esophageal cancer can be different for different patients. Your surgeon will work with you to determine the most effective surgery for the type of esophageal cancer you have.
Combining surgery with other treatments
To achieve the best possible outcome, your care team may recommend combining surgery with other treatments such as radiation therapy or chemotherapy. The additional treatment can be given 1 of 2 ways:
- Neoadjuvant therapy: This treatment occurs before surgery to shrink a tumor and make removal more successful.
- Adjuvant therapy: This treatment occurs after surgery to destroy any lingering cancer cells and reduce the risk of the cancer coming back.
Drug Therapy (Medical Oncology)
Drug therapy, also called systemic or medical therapy, is treatment that works throughout the body to fight Esophageal cancer. These drugs slow the growth of cancer cells or destroy them.
You can receive drug therapy:
• By mouth (orally) as a pill
• Through the blood vessels (intravenously, or IV) as an injection or infusion
At Stanford, our medical oncologists use several types of drug therapy, including:
Chemotherapy Resources
Chemotherapy is a treatment option for many esophageal cancers. We are here to help you prepare and guide you through the process.
Chemotherapy: This group of medications stops the growth of rapidly dividing cells in the body, both cancerous and noncancerous. While powerful, chemotherapy can cause more side effects than other medication types.
Immunotherapy
These medications provoke your immune system to attack cancer cells. Immunotherapy treatments are the newest class of anti-cancer drugs.
The primary types of immunotherapy include:
- Monoclonal antibodies: These are man-made copies of proteins that naturally occur in the immune system. Antibodies can be designed to attack certain features on cancer cells that weaken the cells and cause them to die.
Immunotherapy Resources
Should immunotherapy be part of your care plan, we are here to help you prepare and guide you through the process.
- Immune checkpoint inhibitors: These drugs essentially remove immune system controls and free the immune system to recognize and attack cancer cells.
- Cancer vaccines: Vaccines prompt an immune response against certain diseases. We usually think of vaccines as medications prescribed to fight infections like measles or the flu. Some vaccines can help prevent or treat cancer.
Targeted therapy
These medications slow the growth and spread of cancer by cancer by stimulating the immune system or interfering with specific parts of cancerous cells.
For treatment to work, the cancer must have the specific markers a particular medication was designed to target. Some sarcoma cells have certain proteins on the cells that promote growth. These proteins cause cancer to grow quickly and spread. Our pathologists look for the presence of these proteins by examining samples of tissue taken during a biopsy.
Targeted Therapy Resources
Should targeted therapy be part of your care plan, we are here to help you prepare and guide you through the process.
Drug therapy scheduling
If your treatment plan involves drug therapy, you will have routine visits to have lab work done, see your doctor, and receive medication. You may need to come in once or twice per week. If you need an infusion, you will visit one of Stanford’s infusion treatment centers, where a nurse specializing in Esophageal cancer care will provide your treatment.
Drug therapy side effects
Side effects from drug therapies vary depending on the type of medication you receive. For example, chemotherapy may affect your hair and nails, because it slows their growth as it slows the growth of cancer cells. Fatigue is also possible. Ask your care team – we can help you manage or prevent many symptoms and side effects that can affect your everyday life.
Radiation Oncology
Radiation therapy is painless treatment that uses high-energy X-rays or other types of radiation to destroy cancer cells. Our radiation oncologists have years of experience safely and effectively treating esophageal cancer with radiation. Using the latest technology, we can precisely target tumors and minimize damage to nearby healthy tissue.
Radiation therapy may provide effective treatment for the type of esophageal cancer you have. If so, your doctor will speak with you about the best options. The types of radiation therapy we use for esophageal cancer treatment at Stanford include:
Radiation Therapy Resources
Should radiation therapy be part of your care plan, we are here to help you prepare and guide you through the process.
What to expect during external radiation therapy and how to prepare »
External radiation uses a machine called a linear accelerator (LINAC) to deliver radiation to the area of the esophageal where the cancer cells are found. Some of the types of external radiation we use include:
- 3D (3-dimensional) conformal radiation therapy (3D-CRT)
With this method, 3D images help the doctor better target the tumor. The images are created using a special machine — a computed tomography (CT) or magnetic resonance imaging (MRI) machine. The radiation beams can be aimed from many different angles to match the exact shape of the cancer. - Intensity-modulated radiation therapy (IMRT)
This method is similar to the first method, but the doctor can adjust how much radiation you get from each beam. In certain situations, this allows for better avoidance of nearby normal cells, and thus less potential side effects. - Stereotactic body radiation therapy (SBRT) or stereotactic ablative radiation therapy (SABR)
This method works like the first two methods, and the total amount of radiation you get is similar. But with this method, the radiation is given in fewer but stronger doses.
Receiving radiation treatments
Radiation therapy does not cause pain, so you won’t feel anything during your treatments. Radiation does not make you radioactive, and you can safely be around other people, including children.
The exact number and timing of your radiation treatments depends on the type of esophageal cancer you have and the type of radiation therapy you need:
- Typically, you will be treated once a day, Monday through Friday, over a few weeks.
- Most treatment sessions take 15 to 30 minutes, but some may take up to 1 hour.
- We offer treatment sessions between 8 a.m. and 5 p.m. at our Cancer Centers in Palo Alto, Pleasanton, South Bay, and Turlock.
Radiation therapy side effects
Everyone has a different response to radiation therapy. It may cause short-term side effects during treatment or long-term side effects after treatment ends.
The side effects of treatment depend on the type of radiation you receive, the dose, and your overall health. Common side effects that you may experience after radiation treatment include:
- Fatigue
- Skin color changes, like a tan or sunburn
- Skin irritation
- Nausea and vomiting
- Diarrhea
No matter what you experience, your care team can help ease the side effects of treatment. At least once a week, your radiation oncology team will meet with you to discuss your progress and any side effects that you may have.
Clinical Trials
At Stanford, our doctors are always working to improve care for people with esophageal cancer. As an academic medical center, we conduct clinical trials to evaluate new medical procedures, techniques, devices, medications, and other treatments for safety and effectiveness.
For esophageal cancer, we often study new approaches to preventing, screening, detecting, diagnosing, and treating esophageal cancer. Some clinical trials look at new methods, while others evaluate new combinations of approved, existing approaches.
Depending on your individual circumstances, a clinical trial may provide a treatment option for you. Like any treatment, clinical trials have possible risks and benefits, including:
Possible benefits of joining a clinical trial:
- Access to a new treatment that isn’t widely available
- Expert care from our world-renowned cancer specialists and their teams
- Low- or no-cost treatment
- Participation in research that can save lives in the future
Possible risks of a clinical trial:
- Treatment that may not work for you
- Side effects that may be unexpected or worse than current standard-of-care treatments
- Additional doctor visits, meaning more time and travel
- Additional tests, which may be uncomfortable or time consuming
- Extra expenses if your health insurance does not cover all patient costs for a trial
To learn more about Stanford’s clinical trials for esophageal cancer, speak with your care team. We can help you decide if a clinical trial may be right for you.
When cancer is found in the esophagus, your doctor will study it to assess its stage. Factors that determine the stage include the size of the tumor and whether cancer has spread to other parts of the body.
Staging the cancer helps your doctor tailor a treatment plan. The stages of esophageal cancer are:
The stages of esophageal cancer are:
Stages of squamous cell carcinoma of the esophagus
The stages of squamous cell carcinoma include:
Stage 0 (high-grade dysplasia)
Abnormal cells form in the lining of the esophagus and may turn into cancer.
Stage I
There are 2 sub-stages in Stage I:
- Stage IA: Low grade cancer in the mucosa no spread to surrounding tissue
- Stage IB: The cancer has either of these features:
- Low grade cancer in the submucosa but no spread to nearby tissue or lymph nodes
- Higher grade cancer in the mucosa or submucosa but not spread to nearby lymph nodes
- Low grade cancer in the muscularis propria but no spread to nearby lymph nodes
Stage II
This stage has 2 sub-stages:
- Stage IIA: The cancer has either of these features:
- Low grade cancer in the adventitia but no spread to other areas, with tumor in the middle or upper region of the esophagus
- Higher grade cancer in the muscularis propria but no spread to lymph nodes
- Any grade cancer in the adventitia but no spread to other areas, with tumor in the lower esophagus or unknown location
- Stage IIB: The cancer has either of these features:
- Cancer cells that grow and spread faster in the adventitia, with tumor in the upper or middle esophagus
- Cancer in the mucosa or submucosa and cancer in 1 or 2 nearby lymph nodes
Stage III
There are 2 sub-stages in this stage:
- Stage IIIA: The cancer has any of these features:
- Cancer in the mucosa or submucosa and cancer in 3 to 6 nearby lymph nodes
- Cancer in the muscularis propria and 1 or 2 nearby lymph nodes
- Stage IIIB: Cancer in the adventitia and 1 or 2 nearby lymph nodes
- Cancer in the muscularis propria or adventitia and 3 to 6 nearby lymph nodes
- Cancer in the muscle that divides your chest and abdomen (diaphragm), the sac that encases the heart (pericardium), or the tissue that lines the chest cavity (pleura), and no more than 2 lymph nodes
Stage IV
There are 2 sub-stages in stage IV
- Stage IVA: The cancer has any of these features:
- Cancer in the pleura, diaphragm, or sac that encases the heart, as well as 3 to 6 nearby lymph nodes
- Cancer has spread to nearby organs such as the trachea or spine
- Cancer has spread to 7 or more nearby lymph nodes
- Stage IVB: Cancer has spread outside the esophagus to other areas of the body.
Recurrent: Cancer that has come back after treatment. This may be managed by some combination of surgery, chemotherapy, and radiation therapy.
Many experts can be involved in your care to ensure your specific needs are met. Our esophageal cancer doctors specialize in several different areas of cancer diagnosis and treatment and work together to create a coordinated and comprehensive plan. This group is known as a multidisciplinary team and includes:
Thoracic Surgeons and Surgical oncologists: Cancer surgeons who remove tumors and perform biopsies (small tissue sample to test for cancer) in the abdomen and the chest
- Medical oncologists: Cancer doctors who treat cancer with medications such as chemotherapy and targeted therapy
- Radiation oncologists: Cancer doctors who treat cancer with radiation therapy
- Gastroenterologists: Internal medicine specialists who diagnose and treat conditions of the digestive system.
Your treatment plan will address the following:
- Location, size, and stage of the cancer
- Treatment goals
- Treatment options, their possible side effects, and ways to minimize or relieve side effects
- Expected length of treatment
- Follow-up care after treatment
- Radiologists: Specialists who perform and read imaging tests, such as mammograms and MRI scans, to diagnose and treat cancer
- Pathologists: Doctors who specialize in reading laboratory tests and evaluating tissue samples to diagnose cancer
- Social workers: Professionals with a background in cancer care who specializes in psychological support
- Genetic counselor: Licensed health care professional with specialized training in cancer genetics, testing, and counseling
If you have metastatic esophageal cancer
Metastatic esophageal cancer means that cancer cells have spread from the esophageal and nearby lymph nodes to other parts of the body. The most common locations for metastatic esophageal cancer are the lungs, liver and bones.
Learn more about stage IV esophageal cancer »
If you want a second opinion
If you already have a diagnosis of Esophageal cancer and want a second opinion about treatment options, we can usually schedule you within 14 days. Your reason for seeking a second opinion will help us determine which specialist(s) you should see:
- If you are still deciding how or where you will receive treatment, you may see a medical oncologist, radiation oncologist, or a surgeon.
- If you need a second opinion about drug therapy, you will see a medical oncologist.
- If you need a second opinion about surgery, you will see our surgeons.